萬有，男，畢業于鄭州大學醫學院，博士學位，博士后學歷，北京大學基礎醫學院神經生物學系教授、博士生導師、系主任，神經科學研究所所長，基礎醫學院院長、黨委書記，??教育部和衛生部神經科學重點實驗室主任，科技部“973”項目首席科學家。
萬有教授的主要研究方向為疼痛慢性化的學習記憶、情緒與認知及其調控機制、 疼痛與鎮痛的神經科學機制、針刺鎮痛的神經生物學機制。
人物經歷
1985年于河南醫科大學醫療系獲醫學學士學位;1990年于河南醫科大學藥理教研室獲碩士學位，1993年于武漢同濟醫科大學病生教研室獲博士學位，1995原北京醫科大學生理教研室博士后出站。1998至2000年美國伊利諾伊大學和新澤西州大學訪問學者。于首都醫科大學和北京大學醫學部歷任講師(1996年)、副教授(1997年)和教授(2001)。
社會任職
博士學位，博士后學歷，教授，博士生導師
教育部和衛生部神經科學重點實驗室，主任
北京大學神經科學研究所，所長
北京大學神經生物學系，主任
北京大學基礎醫學院，院長、黨委書記
中國神經科學學會理事兼副秘書長，中華醫學會疼痛分會常務委員，中國針灸學會針刺麻醉與針刺鎮痛原理分會副理事長，北京神經科學學會理事兼秘書長。國際疼痛學會中國分會主席。國際疼痛學會(IASP)會員，中國生理學會會員。
《神經損傷與功能重建》副主編；《生理科學進展》、《針刺研究》、《生物化學與生物物理進展》、<神經科學 Bulletin>編委；十余種國內外核心期刊與SCI收錄學術刊物特約審稿人。
獲得榮譽
(1) 集體獎：國家級神經生物學重點學科、國家級精品課程、國家自然基金委創新群體、教育部創新團隊。
(2) 個人獎：國務院政府特殊津貼、國家新世紀百千萬人才工程、教育部跨世紀優秀人才計劃、北京市教委北京市優秀博士學位論文指導教師，以及北京大學方正獎教金教師優秀獎、北京大學研究生“十佳導師”。
(3) 科研獎：國際疼痛學會疼痛研究杰出獎、中國針灸學會科學技術獎、北京市科學技術獎。
2003年獲教育部“跨世紀優秀人才培養計劃”，2004年度入選國家人事部等八部委批準的“新世紀百千萬人才工程”國家級人選，2007年獲得國務院政府特殊津貼。
主要成就
研究方向
感覺系統的分子神經科學：疼痛與鎮痛的機制。
采用分子生物學、細胞生物學、形態學、電生理學(大體電生理和膜片鉗)、藥理學和行為學等多種方法，研究背根神經節、脊髓背角和腦內高級中樞神經元和膠質細胞神經遞質、受體、離子通道以及神經網絡在痛覺調制中的作用，目的在于闡明疼痛尤其是慢性痛的機制。
個人項目
2016.01-2019.12: 國家自然科學基金面上項目“酪氨酸磷酸酶Shp-1調節外周TRPV1受體去磷酸化參與大鼠慢性炎癥痛的機制研究”(81571067)
2013.1-2017.12: 科技部重大基礎研究計劃(“973”)項目“基于臨床的針麻鎮痛與機體保護機制研究”（2013CB531900，項目首席科學家）
2013.1-2016.12: 國家自然科學基金重點項目“慢性痛發生發展的大腦痛矩陣動態腦功能網絡及其特征研究”(81230023)
2012.1-2015.12: 國家自然科學基金面上項目“Ⅰ型胰島素樣生長因子上調辣椒素受體參與骨癌痛的機制研究”(81171042)
2012.1-2012.13: 中國中醫科學院針灸研究所開放選題項目“針刺鎮痛的神經科學機制”(ZZ04004)
2011-12-2013.12: 教育部高等學校博士學科點專項科研基金“Ⅰ型胰島素樣生長因子上調辣椒素受體參與骨癌痛的機制研究”(20110001110058).
2011.1-2013.12: 國家自然科學基金面上項目“癌細胞分泌內源性甲醛導致癌癥痛及其細胞分子機制研究”(81070893)
2010.1-2012.12: 北京市教育委員會“北京市優秀博士學位論文指導教師－腫瘤細胞分泌的甲醛作用于辣椒素受體(TRPV1)引發骨癌痛”
2007.7-2011.8: 科技部重大基礎研究計劃(“973”)課題“針麻鎮痛中高級中樞痛覺信息調制回路的作用”(2007CB512501)
2006.1-2008.12: 國家自然科學基金面上項目“背根神經節神經元辣椒素受體及其表達的移型參與慢性炎性痛的機制”(30570566)
2005.1-2007.12: 北京市自然科學基金項目“氫氰酸通道參與大鼠慢性神經病理痛的機制”(7052039)
2005.1-2007.12: 國家自然科學基金面上項目“超極化激活環核苷酸門控離子通道參與大鼠慢性神經病理痛的機制”(30470559)
2003.1-2005.12: 教育部2003年度“跨世紀優秀人才培養計劃”超極化激活環核酸門控離子通道(HCN)在神經病理痛中的作用
2002.1-2004.12: 國家自然科學基金面上項目“d-阿片受體在B10和B6小鼠不同針刺鎮痛反應中的作用”(30170319)
2003.1-2003.12: 國家自然科學基金主任基金項目“超極化激活離子通道在大鼠慢性神經源性痛中的作用”(30240059)
2002年度教育部“優秀青年教師資助計劃”
2001.9: 教育部留學回國啟動基金“d-阿片受體在B10和B6小鼠不同針刺鎮痛反應中的作用”
1998.10-2000.8: 美國NIH NIDA/INVEST Fogarty基金“針刺鎮痛差異的遺傳學機制”
1998.1-2000.12: 國家自然科學基金面上項目“膜片鉗結合單細胞PCR研究阿片肽/抗阿片肽的分子機制”(39770241)
1997.1-1999.12: 國家自然科學基金面上項目“腺病毒載體介導的脊髓損傷GDNF基因治療”(39600150)
1993.12-1995.12: 中國博士后基金“帕金森病基因治療的試驗研究”
學術論文
Jie Zheng, Ying-Ying Jiang, Long-Yu Ma, Feng-Yu Liu, Shuang Cui, Jie Cai, Fei-Fei Liao,?You Wan*, Ming Yi*. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice.?The Journal of 神經科學2017 (accepted)
Meng Zhang, Jie Cai, Jia Liu, Meng-Meng Zhou, Honghai Wu, Yanning Hou, Yun-Feng Li, Yuxin Yin, Lemin Zheng, Fei-Fei Liao, Feng-Yu Liu, Ming Yi*,?You Wan*. Anxiolytic-like effects of elevated neurosteroids in the hippocampus in neuropathic pain rats with spared nerve injury.?Journal of Neurochemistry?2017 (accepted)
Chan Zhang, Rong-Xiang Chen, Yu Zhang, Jie Wang, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Fu-Qiang Xu, Ming Yi*,?You Wan*. Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.?Scientific Reports?2017; 7: 41439. doi: 10.1038/srep41439.
Ming-Jia Li, LingYu Liu, Lin Chen, Jie Cai,?You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain via the integration of 應力affect related information with nociceptive information in the central 細胞核 of the amygdala.?Pain2017 (accepted)
Yu Zhang, Yingying Jiang, Shan Shao, Chan Zhang, Feng-Yu Liu,?You Wan, Ming Yi*. Inhibiting medial septal cholinergic neurons with DREADD alleviated anxiety-like behaviors in mice.?Neuroscience Letters2017; 638: 139-144.
Jing Wang, Jing Wang, Guo-Gang Xing, Xiaoli Li*,?You Wan*. Enhanced gamma oscillatory activity in rats with chronic inflammatory pain.?Frontiers in Neuroscience2016; 10: 489. doi: 10.3389/fnins.2016.00489.
Meng Zhang, Jia Liu, Meng-Meng Zhou, Hong-Hai Wu, Yan-Ning Hou, Yun-Feng Li, Yu-Xin Yin, Le-Min Zheng, Feng-Yu Liu, Ming Yi*,?You Wan*. Elevated neuro固醇類 in the lateral thalamus relieve neuropathic pain in rats with spared nerve injury.?神經科學 Bulletin2016, 32(4):311322. doi 10.1007/s12264-016-0044-7
Jie Zheng, Ming Yi,?You Wan*. Hippocampal neurogenesis: Does it relieve or worsen chronic pain? (Correspondence. Letter to Editor)?Pain2016; 157: 506-507.
Xing Liu, Jing Wang, Baoguo Wang*, Ying Hua Wang, Qinglei Teng, Jiaqing Yan, Shuangyan Wang,?You Wan*. Effect of transcutaneous acupoint electrical stimulation on propofol sedation: an electroencephalogram analysis of patients undergoing pituitary adenomas resection.?BMC Complementary and Alternative 藥品2016 Jan 27; 16(1): 33. doi: 10.1186/s12906-016-1008-1
Xiang-Yao Li,?You Wan, Shao-Jun Tang, Yun Guan, Feng Wei, and Daqing Ma. Maladaptive Plasticity and Neuropathic Pain. (Editorial)?Neural Plasticity2016; 2016: 4842159. doi: 10.1155/2016/4842159.
Haolin Zhang, Jungang Sun, Chao Wang, Congcong Yu, Weiwei Wang, Meng Zhang, Lixing 老撾語, Ming Yi*,?You Wan*. Randomised controlled trial of contralateral manual Acupuncture for the 浮雕 of chronic shoulder pain.?Acupuncture in Medicine2016 Jun; 34(3): 1164-1170. doi: 10.1136/acupmed-2015-010947.
Juan Wang, Ming Yi, Chan Zhang, Zhijie Bian,?You Wan, Rixin Chen, Xiaoli Li. Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA.?Cognitive Neurodynamics2015 Dec; 9(6): 581-588. doi: 10.1007/s11571-015-9349-x.
Juanjuan Wang, Y Zhang, Jie Hou, Xianghao Qian, H Zhang, Zhiling Zhang, M Li, R Wang, K Liao, Y Wang, Zhaoyan Li, Dan Zhong, P Wan, L Dong, Feng-Yu Liu, X Wang,?You Wan, Wei Xiao, Weiwei Zhang*. Ube2s regulates Sox2 stability and mouse ES cell maintenance.?Cell 死亡 and Differentiation2016 Mar; 23(3): 393-404. doi: 10.1038/cdd.2015.106.
Yufei Mei?, Chun Jiang?,?You Wan, Jihui Lv, Jianping Jia, Xiaomin Wang, Xu Yang*, Zhiqian Tong*. Aging-associated formaldehyde-induced norepinephrine deficiency contributes to agerelated memory decline.?Aging Cell2015 Aug; 14(4):659-668. doi: 10.1111/acel.12345.
Xu Ding, Jie Cai, Song Li, Xiao-Dan Liu,?You Wan*, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by Induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation.?神經科學 of Disease2015; 73: 428-451. doi: 10.1016/j.nbd.2014.10.025.
Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi,?You Wan*. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in 家鼠屬?Pain2015 April; 156(4): 597–608. doi: 10.1097/01.j.pain.0000460351.30707.c4.
Xiao-Dan Liu, Jing-Jing Yang, 越南盾 Fang, Jie Cai,?You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 鈉 Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain.?PLoS One2014; (12): e114623. doi:10.1371/journal.pone.0114623.
Hong Jiang, 越南盾 Fang, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang,?You Wan*, Guo-Gang Xing*. Sensitization of neurons in the central 細胞核 of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in 家鼠屬?Molecular Brain2014; 7: 72.
Fei-Fei Liao, Chan Zhang, Zhijie Bian, Dingyi Xie, Mingfei Kang, Xiaoli Li,?You Wan, Rixin Chen*, Ming Yi*. Characterizing heat-sensitization phenomena in suspended moxibustion with high-密度 EEG.?Pain Medicine2014; 15(8): 1272-1281.? doi: 10.1111/pme.12512.
Yu Zhang, Feng-Yu Liu,?You Wan, Ming Yi*. Exacerbation of tonic but not phasic pain by entorhinal cortex lesions.?Neuroscience Letters2014; 581: 137-142.? doi: 10.1016/j.neulet.2014.05.015.
Fei Yang, Jia Guo, Wei-Liang Sun, Feng-Yu Liu, Jie Cai, Guo-Gang Xing,?You Wan*. The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in 家鼠屬?神經科學2014; 269: 59–66.
Yan Li, Jie Cai, Ying Han, Xing Xiao, Xiang-Ling Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing,?You Wan*. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain.?European Journal of Pain2014; 18(6): 774-784.? doi: 10.1002/j.1532-2149.2013.00420.x.
Zheng Li, Jing Wang, Lin Chen, Meng Zhang,?You Wan*. Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain 家鼠屬?PLoS One2013; 8(8): e70921.? doi:10.1371/journal.pone.0070921.
Haolin Zhang, Xiaolong Chen, Chan Zhang, Ruixin Zhang, Li-Xing 老撾語,?You Wan* and Ming Yi*. Comparison of restrained and unrestrained rat models of electro-Acupuncture in 家鼠屬?Evidence-Based Complementary and Alternative Medicine2013; 2013: Article ID 404956. http://dx.doi.org/10.1155/2013/404956.
Jing Wang, Jing Wang, Duan Li, Xiao-Li Li,?You Wan*. Modulation of brain electroencephalography oscillations by electro-Acupuncture in a rat model of post-incisional pain.?Evidence-based Complementary and Alternative Medicine2013; vol 2013, article ID 160357. doi:10.1155/2013/160357.
Jia Liu, Feng-Yu Liu, Zhi-Qian Tong, Zhi-Hua Li, Wen Chen, Wen-Hong Luo, Hui Li, Hong-Jun Luo, Yan Tang, Jun-Min Tang, Jie Cai, Fei-Fei Liao,?You Wan*. Lysine-specific demethylase 1 (LSD1) in the breast cancer cells contributes to the production of endogenous formaldehyde in metastatic bone cancer pain model of 家鼠屬.?PLoS One2013; 8(3): e58957. doi: 10.1371/journal.pone.0058957.
Zhiqian Tong, Chanshuai Han, Wenhong Luo, Hui Li, Hongjun Luo, Min Qiang, Tao Su, Beibei Wu, Ying Liu, Xu Yang,?You Wan, Dehua Cui*, Rongqiao He*. Aging-associated excess formaldehyde leads to spatial memory deficits.?Scientific Reports2013; 3: 2045-2322. DOI: 10.1038/srep01807.
Min Liu, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai,?You Wan, Dehua Chui, Ji-Sheng Han, and Guo-Gang Xing. Up-regulation of P2X3receptors by neuronal 鈣 sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain.?Pain2013; 154(9): 1551–1568.
Qin Zheng, Dong Fang, Ming Liu, Jie Cai,?You Wan, Ji-Sheng Han, Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) 鉀 channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.?Pain2013; 154(3): 434-448.
YENan Chi, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing,?You Wan*. Formaldehyde increases intracellular 鈣 concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels.?神經科學 Bulletin2012; 28(6): 715-722.
Shenglan Wang, Yi Dai, Kimiko Kobayashi, Wanjun Zhu, Yoko Kogure, Hiroki Yamanaka,?You Wan, Wensheng Zhang and Koichi Noguchi*. Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase dependent mechanisms, contributes to inflammatory pain.?European Journal of 神經科學2012; 36(3): 2293-2301.
Wenbing Dai, Wu Jin, Junlin Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang,?You Wan, Qiang Zhang*. Spatiotemporally controlled co-delivery of anti-vasculature agent and cytotoxic drug by octreotide-modified stealth liposomes.?Pharmaceutical Research2012; 29(10): 2902-2911.
Qin Zheng, Dong Fang, Jie Cai,?You Wan, Ji-Sheng Han and Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain.?Molecular Pain2012; 8: 24.
Ying Han, Yan Li, Xing Xiao, Jia Liu, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing,?You Wan*. Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in bone cancer pain model of rats.?神經科學 Bulletin2012; 28(2): 165-172.
Chang-Qing Yang, Yan-Yu Wei, Yu-Xin Leng, Chan-Juan Zhong, Yong-Shen Zhang,?You Wan, Li-Ping Duan*. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in 家鼠屬?Digestive Diseases and Sciences2012; 57(4): 865-872.
Feng-Yu Liu, Yan-Ni Sun, Fa-Tian Wang, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang Xing,?You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation.?Brain Research2011; 1427: 65-77.
Ming Yi*, Haolin Zhang, Lixing 老撾語, Guo-Gang Xing,?You Wan*. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral 銀金礦Acupuncture in the formalin-induced inflammatory pain model of rats.?Molecular Pain2011; 7: 61-67.
Jing Wang, Duan Li, Xiaoli Li, Feng-Yu Liu, Guo-Gang Xing, Jie Cai,?You Wan*. Phase – amplitude coupling between theta and gamma oscillations during nociception in rat electroencephalogram.?Neuroscience Letters2011; 499: 84-87.
Feng-Yu Liu, Xiao-Xiu Qu, Jie Cai, Fa-Tian Wang, Guo-Gang Xing and?You Wan*. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation.?神經科學 Bulletins2011; 27(1): 1-8.
Zhiqian Tong, Jinling Zhang, Wenhong Luo, Weishan Wang, Fangxu Li, Hui Li, Hongjun Luo, Jing Lu, Jiangning Zhou,?You Wan, Rongqiao He*.?Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia.?神經科學 of?Aging2011; 32(1): 31-41.
Dong Cui, Xianzhen Liu,?You Wan, Xiaoli Li*. Estimation of genuine and random synchronization in multivariate neural series.?Neural Networks2010; 23: 698-704.
Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang,?You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation.?Brain Research2010; 1330: 45-60.
Zhiqian Tong*, Wenhong Luo, Yanqing Wang, Fei Yang, Ying Han, Hui Li, Hongjun Luo, Bo Duan, Tianle Xu, Qiliang Mao-Ying, Huangying Tan, Jun Wang, Hong寐龍屬 Zhao, Feng-Yu Liu,?You Wan*. Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain.?PLoS One2010; 5(4): e10234.? doi:10.1371/journal.pone.0010234
Shan-Jing Geng, Fei-Fei Liao, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han,?You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation.?Experimental Neurology2010; 222(2): 256-266.
Xiao-Xiu Qu, Jie Cai, Ming-Jia Li, YENan Chi, Fei-Fei Liao, Feng-Yu Liu,?You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain.?Experimental Neurology2009; 215(2): 298-307.
Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing,?You Wan*. The role of TRPV1 in different types of dorsal root ganglion neurons in chronic inflammatory nociception induced by complete Freund’s adjuvant.?Molecular Pain2008; 4: 61-70.
Hao Luo, Isabella Shi Xu, Yi Chen, Lu Yu, Fei Yang, Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing, Yu-Shun Shi, Tan Li, Ji-Sheng Han,?You Wan*. Behavioral and electrophysiological evidence for the differential 函數s of TRPV1 at early and late stages of chronic inflammatory nociception in 家鼠屬?Neurochemical Research2008; 33(10): 2151-2158.
Cheng Huang, Zhi-Qin Huang, Zhi-Ping Hu, Shao-Zu Jiang, Han-Ting Li, Ji-Sheng Han,?You Wan*. Electroacupuncture effects in a rat model of complete Freund's adjuvant-induced inflammatory pain: antinociceptive effects enhanced and tolerance development accelerated.?Neurochemical Research2008; 33(10): 2107-2111.
Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, YENan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han,?You Wan*. Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat.?Pain2008; 137: 495-506.
Yue Lu, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing,?You Wan*. Role of α-氨基3-hydroxy-5-甲基4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat.?Brain Research2008; 1200: 19-26.
Yu-Qiu Jiang, Qian Sun, Hui-Yin Tu,?You Wan*. Characteristics of 氫氰酸 channels and their participation in neuropathic pain.?Neurochemical Research2008; 33(10): 1979-1789. (Review)
Albert CH Yu,?You Wan, De-Hua Chui, Cai-Lian Cui, Fei Luo, Ke-Wei Wang, Xiao-Min Wang, Yun Wang, Liu-Zhen Wu, Guo-Gang Xing, Ji-Sheng Han. The Neuroscience Research Institute at Peking University: A place for the solution of pain and drug abuse.?Cellular Molecular 神經科學2008; 28(1): 13-19. (ReFIELD OF VIEW)
Guo-Gang Xing*, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han,?You Wan. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroAcupuncture in rats with neuropathic pain.?Experimental Neurology2007; 208(2):323-332.? (Co-corresponding author. Erratum has been made)
Feng-Yu Liu, Guo-Gang Xing, Xiao-Xiu Qu, Isabella Shi Xu, Ji-Sheng Han,?You Wan*. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on the C-fiber responses of the spinal wide dynamic range neurons in 家鼠屬.?The Journal of 藥理學 and Experimental Therapeutics2007; 321(3): 1046-1053.
Fei-Yu Zhang,?You Wan, Zhen-Kang Zhang, Alan R Light, Kai-Yuan Fu*. Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord.?TheJournal of Pain2007; 8(2): 110-117.
Cheng Huang, Zhi-Ping Hu, Shao-Zu Jiang, Han-Ting Li,?You Wan*. CCKBreceptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture induced analgesia in mice.?Brain Research Bulletin2007; 71(5): 447–451.
Wei Li,?You Wan, Ji-Sheng Han, Jiu-Ping Ding, Tao Xu*. Inactivating 鈣-activated 鉀 currents in rat dorsal root ganglia neurons.?Progress in Biochemistry and Biophysics2005; 32(5): 408-412.
Xiao Mei Qin,?You Wan, Xian Wang*. CCL2 and CXCL1 trigger 降鈣素 gene-related peptide release by exciting primary nociceptive neurons.?Journal of 神經科學 Research2005; 82(1): 51-62.
Byung-Tae Choi, Jun-Hyuk Lee,?You Wan, Ji-Sheng Han*. Involvement of ionotropic glutamate receptors in low 頻率 electroacupuncture analgesia in 家鼠屬?Neuroscience Letters2005; 377(3): 185-188.
Qian Sun, Guo-Gang Xing, Hui-Yin Tu, Ji-Sheng Han,?You Wan*. Inhibition of hyperpolarization-activated current (Ih) suppresses ectopic discharges from injured dorsal root ganglion neurons in a rat model of neuropathic pain.?Brain Research2005; 1032(1-2): 63-69.
Qian Sun, Hui-Yin Tu, Guo-Gang Xing, Ji-Sheng Han,?You Wan*. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation.?Experimental Neurology2005; 191(1): 128-136.
Cheng Huang, Hua Long, Yu-Shun Shi, Ji-Sheng Han,?You Wan*. Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in 家鼠屬?Neuroscience Letters2005; 375(2): 138-142.
Xiao-Qing Tang, Yun Wang, Zhi-Hua Huang, Ji-Sheng Han,?You Wan. Adenovirus- mediated delivery of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury.?NeuroReport2004; 15(3): 425-429.
Hao Luo, Jin Cheng, Ji-Sheng Han,?You Wan*. Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in 家鼠屬?NeuroReport2004; 15(4): 655-658.
Cheng Huang, Han-Ting Li, Yu-Shun Shi, Ji-Sheng Han,?You Wan*. Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain.?Neuroscience Letters2004; 368(3): 327-331.
Huiyin Tu, Lunbin Deng, Qian Sun, Lei Yao, Ji-Sheng Han,?You Wan*. Hyperpolarization-activated, cyclic nucleotide-gated cation channels: roles in the differential electrophysiological properties of rat primary afferent neurons.?Journal of 神經科學 Research2004; 76(5): 713-722.
Cheng Huang, Zhi-Ping Hu, Hua Long, Yu-Shun Shi, Ji-Sheng Han,?You Wan. Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture and the involvement of opioids in rat model of chronic inflammatory pain.?Brain Research Bulletin2004; 63(2): 99-103.
Rui-Qing Sun, He-Chun Wang,?You Wan, Zheng Jing, Fei Luo, Ji-Sheng Han, Yun Wang*. Suppression of neuropathic pain by peripheral electrical stimulation in rats: m-opioid receptor and NMDA receptor implicated.?Experimental Neurology2004; 187(1): 23-29.
De-Run Tian, Xiao-Dong Li, Yu-Shun Shi,?You Wan, Xiao-Min Wang, Jaw-Kang Chang, Jun Yang, Ji-Sheng Han*. Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats.?Peptides2004; 25(12): 2147-2153.
Cheng Huang, Hua Long, Ji-Sheng Han,?You Wan. Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice.?Neuroscience Letters2003; 350(2): 93-96.
Cheng Huang, Yun Wang, Ji-Sheng Han,?You Wan. Characteristics of electroacupuncture- induced analgesia in different strains of mice.?Brain Research2002; 945(1): 20-25.
William R. Lariviere, Sonya G. Wilson, Tinna M. Laughlin, Anna Kokayeff, Erin E. West, Seetal M. Adhikari,?You Wan, Jeffrey S. Mogil*. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity.?Pain2002; 97(1-2): 75-86.
Xiao-Qing Tang, Yun Wang, Ji-Sheng Han,?You Wan. Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury.?NeuroReport2001; 12(14): 3073-3076.
You Wan, Sonya G. Wilson, Ji-Sheng Han, Jeffrey S. Mogil*. The effect of genotype on sensitivity to electroacupuncture analgesia.?Pain2001; 91(1-2): 5-13.
Zou Han, Yu-Hui Jiang,?You Wan, Yun Wang, Jaw-Kang Chang, Ji-Sheng Han*. Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat.?Neuroscience Letters1999; 274: 75-78.
Min Zhang, Qi-Lun Sun,?You Wan, Lei Yao, Ying-Xin Yu, Ji-Sheng Han*. OFQ reverses the kappa-opioid 捕手mediated depression of calcium current in the dorsal root ganglion neurons.?NeuroReport1998; 9: 2095-2098.
Duan-Duan Ma, Xiao-Min Wang, Xing-Jun Jing, Ji-Ou Wang, Liang Xiong, Hao Song,?You Wan, Guo-Heng XuH, Qi-Lun Sun, Hong-Wei Dong, Xin-Hong Wang, Ji-Sheng Han*. GDNF cDNA-enginered NIH 3T3 cells protect primary dopaminergic neurons.?Chinese Science Bulletin1997; 42: 1921-1924.
參考資料 >
萬有教授.北大醫學部神科所.2020-10-31