沈玉先，女，1965年生于潁上縣，1989年畢業(yè)于安徽醫(yī)科大學(xué)醫(yī)學(xué)系，現(xiàn)為安徽醫(yī)科大學(xué)教授，碩士生導(dǎo)師。沈玉先的主要社會(huì)任職有：中國(guó)藥理學(xué)會(huì)抗炎免疫專業(yè)委員會(huì)委員、中國(guó)醫(yī)刊編委、中國(guó)藥理學(xué)通報(bào)編輯、Free Radical Bio Med, Neurosci Res,J Pharm Pharmacol, Arch Linux Med Res, Acta Pharmacol Sin, Medical Science Monitor等期刊的審稿人。發(fā)表專業(yè)論文80余篇，其中2002年度以第一作者發(fā)表SCI論文數(shù)在全國(guó)科技論文統(tǒng)計(jì)中居醫(yī)藥類首位（4篇）。目前承擔(dān)的課題有國(guó)家自然科學(xué)基金面上項(xiàng)目、教育部人才基金、教育部重點(diǎn)項(xiàng)目、中國(guó)博士后基金一等資助、教育部回國(guó)人員基金、安徽省優(yōu)秀人才基金等，并作為主要研究人員參與國(guó)家973項(xiàng)目的研究。參編大型參考書4部如《藥理實(shí)驗(yàn)方法學(xué)》、《中華臨床藥物學(xué)》（編委）、《治療學(xué)的藥理學(xué)基礎(chǔ)》等。
人物經(jīng)歷
1984 ~ 1989 安徽醫(yī)科大學(xué)醫(yī)學(xué)系 本科/學(xué)士。
1989 ~ 1992 安徽醫(yī)科大學(xué)藥理學(xué)專業(yè) 研究生/碩士。
1997 ~ 2000 安徽醫(yī)科大學(xué)藥理學(xué)專業(yè) 研究生/博士。
1992 ~ 1995 安徽醫(yī)科大學(xué)臨床藥理研究所 助教。
1995 ~ 1999 安徽醫(yī)科大學(xué)臨床藥理研究所 講師。
1999 ~ 2003 安徽醫(yī)科大學(xué)臨床藥理研究所 副教授。
2003 ~ 2004 美國(guó)馬利蘭大學(xué)生物技術(shù)研究所 博士后研究。
2005 ~ 2008 中國(guó)科學(xué)技術(shù)大學(xué)生命科學(xué)院 博士后研究。
2003 ~ 2007 安徽醫(yī)科大學(xué)臨床藥理學(xué)研究所 教授。
2007 ~ 2010 安徽醫(yī)科大學(xué)“重要遺傳疾病基因資源利用”教育部重點(diǎn)實(shí)驗(yàn)室 教授。
2009 ~ 2010 安徽醫(yī)科大學(xué)護(hù)理學(xué)院 副院長(zhǎng)。
2010 ~ 2012 安徽醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院 教授，副院長(zhǎng)。
2012 ~ 安徽醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院 教授，院長(zhǎng)。
科研項(xiàng)目
主持的科研項(xiàng)目有：
1. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，81973336，神經(jīng)因子MANF介導(dǎo)的單核/巨噬細(xì)胞表型及功能的可塑性對(duì)肝纖維化的抑制作用及機(jī)制研究，2020-01至2023-12，在研，主持；
2. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，81673438，肝細(xì)胞源性神經(jīng)營(yíng)養(yǎng)因子MANF經(jīng)外泌體靶向HSCs的抗肝纖維化作用及機(jī)制研究，2017-01至2020-12，在研，主持；
3. 安徽省轉(zhuǎn)化醫(yī)學(xué)研究院，科研基金項(xiàng)目，2017zhyx34，基于新型神經(jīng)營(yíng)養(yǎng)因子MANF的雙級(jí)靶向納米遞送系統(tǒng)的設(shè)計(jì)及其在腦梗死治療中的應(yīng)用，2018-01至2020-12，在研，主持；
4. 安徽省教育廳，安徽省領(lǐng)軍人才團(tuán)隊(duì)項(xiàng)目，慢性應(yīng)激與重大疾病研究，2017-01至2018-12，400萬元，已結(jié)題，團(tuán)隊(duì)帶頭人；
5. 國(guó)家科技部，國(guó)家重點(diǎn)研發(fā)計(jì)劃重大慢性非傳染性疾病防控研究項(xiàng)目，2016YFC1305902，基于單細(xì)胞基因表達(dá)譜的神經(jīng)環(huán)路解析，2016-09至2020-12，在研，子課題負(fù)責(zé)人；
6. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，81372576，新型神經(jīng)營(yíng)養(yǎng)因子MANF對(duì)肝細(xì)胞癌的抑制作用及其機(jī)制研究，2014-01至2017-12，已結(jié)題，主持；
7. 國(guó)家自然科學(xué)基金委員會(huì)，重大研究計(jì)劃（培育項(xiàng)目），91129729，內(nèi)質(zhì)網(wǎng)應(yīng)激在乙型肝炎肝硬化肝癌轉(zhuǎn)化過程中的調(diào)節(jié)機(jī)制及相關(guān)藥物作用靶分子篩選，2012-01至2014-12，已結(jié)題，主持；
8. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，81173074，炎癥誘導(dǎo)的ARMET轉(zhuǎn)錄激活及其對(duì)NF-κB信號(hào)通路的調(diào)節(jié)機(jī)制，2012-01至2015-12，已結(jié)題，主持；
9. 國(guó)家教育部，博士點(diǎn)基金（博導(dǎo)類），20113420110004，炎癥誘導(dǎo)的ARMET轉(zhuǎn)錄激活及其對(duì)NF-κB信號(hào)通路的調(diào)節(jié)機(jī)制，2012-01至2014-12，已結(jié)題，主持；
10. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，81072651，內(nèi)質(zhì)網(wǎng)應(yīng)激蛋白ARMET對(duì)關(guān)節(jié)炎滑膜細(xì)胞過度增殖的負(fù)性調(diào)控，2011-01至2011-12，已結(jié)題，主持；
11. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，30772557，泛素連接酶Hrd1介導(dǎo)的tau蛋白降解，2008-01至2010-12，已結(jié)題，主持；
12. 安徽省科技廳，科技攻關(guān)計(jì)劃項(xiàng)目，07010300191，內(nèi)質(zhì)網(wǎng)應(yīng)激蛋白stresslin檢測(cè)方法的建立及臨床應(yīng)用， 2007-01至2009-12，已結(jié)題，主持；
13. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，30572219，泛素連接酶hHrd1對(duì)1-抗胰蛋白酶Z變異型的降解的調(diào)控機(jī)制，2006-01至2008-12，已結(jié)題，主持；
14. 國(guó)家教育部，重點(diǎn)項(xiàng)目，206067，泛素連接酶 hHrd1和異常磷酸化tau功能性相互作用研究， 2006-1至2008-12 ，已結(jié)題，主持；
15. 國(guó)家教育部，新世紀(jì)優(yōu)秀人才支持計(jì)劃，NCET-04-0589，泛素-蛋白酶體通路調(diào)控1-抗胰蛋白酶Z變異型的降解，2005-01至2007-12，已結(jié)題，主持；
16. 中國(guó)博士后科學(xué)基金會(huì)，一等資助，2005038011，泛素連接酶 hHrd1和異常磷酸化tau功能性相互作用研究，2005-01至2007-12，已結(jié)題，主持。
主要論文
1. Hou C, Wang D, Zhao MX, Ballar P, Zhang XR, Mei Q, Wang W, Li X, Sheng Q, Liu J, Wei CS, Shen YJ, Yang Y, Wang P, 邵姓 JT, Sun Y*, Shen YX*. MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis. Acta Pharmaceutica Sinica B. Jun-13, 2023. Accepted (IF=14.5).
2. Yang L, Shen WW, Shao W, Zhao Q, pang GZ, Yang Y, Tao XF, Zhang WP, Mei Q, Shen YX*. MANF ameliorates DSS-induced mouse 結(jié)腸炎 via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway. Acta Pharmacol Sin. 2023 Jun; 44(6): 1175–1190 (IF=8.2).
3. Shen WW, Yang L, Yang Y, Wang P, Tao XF, Shen YJ, Wang S, Shen YX*. PRDX6 promotes fatty acid oxidation via PLA2-dependent PPARα activation in rats fed high-fat diet. Antioxid Redox Signal. 2023 Feb 7 (IF=6.6).
4. Chen H, Zhu T, Huang X, Xu WS, Di Z, Ma YY, Xue M, Bi SX, Shen YJ, Yu YY, Shen YX*, Feng LJ*. Xanthatin suppresses proliferation and tumorigenicity of glioma 細(xì)胞s through autophagy inhibition via activation of the pi3kAkt-mTOR pathway. Pharmacol Res Perspect. 2023 Feb; 11 (1): e1041.
5. Tao XF, Wang D, Liang YY, Yang L, He EG, Zhou J, He YF, Liang JX, Wang P, Chhetri G, Li Q, Shen YJ, Shen YX*. PRDX6 inhibits hepatic stellate cells acti-vation and fibrosis via promoting MANF secretion. 生物醫(yī)學(xué) & Pharma-cotherapy 2022, 156,113931.（IF=7.5）
6. Shen QY, Wang D, Xu HY, Wei CS, Xiao XY, Liu J, Shen YJ, Fang L, Feng LJ, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor attenuates acute lung injury via inhibiting macrophages' activation. Biomed Pharma-cother 2022, 150: 112943.（IF=7.5）
7. Xie YJ, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zim-mermann MT, Wilcox DA, Gutterman DD, Shen YX*, Zhang DX*. NADPH oxidase 4 contributes to TRPV4?mediated endothelium?dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. Basic Res Cardiol 2022, 117(1): 24. (IF=9.5)
8. Hou X#, Liu Q#, Gao YM#, Yong L, Xie HY, Li WT, Zhou YP, Liu J, Feng LJ, Xu L, Shen YX*, Wang H*. Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate 對(duì)乙酰氨基酚induced acute liver injury via p38 MAPK pathway. Cell 死亡 Dis 2022, 13(2): 100.（IF=9.0）
9. Xu HY, Jiao YH, Li SY, Zhu X, Wang S, Zhang YY, Wei YJ, Shen YJ, Wang W, Shen YX*, Shao JT*. Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in 鼠科 via enhancing ASS1 activity and activating AMPK pathway. Acta Pharmacol Sin. 2022, 44(1):157-168.（IF=8.2）
10. Zhao TT#, 越南盾 FQ#, Hu XL, Xu YL, Wei WM, Liu R, Yu F, Fang WJ*, Shen YX*, Zhang ZP*. Dynamic Tracking of p21 mRNA in Living 細(xì)胞s by Sticky-Flares for Visual Evaluation of Tumor Treatment Effect. Nanoscale 2022; 14 (5): 1733-1741.（IF=6.7）
11. Liu C, Liu J, Shao JT, Huang C, Dai XL, Shen YJ, Hou WS, Shen YX*, Yu YQ*. MAGED4B Promotes Glioma Progression via Inactivation of the TNF α induced Apoptotic Pathway by Down regulating TRIM27 Expression. Neurosci Bull 2022, 39(2):273-291 (IF=5.6).
12. Zhao Q, Sheng MF, Wang YY, Wang XY, Liu WY, Zhang YY, Ke TY, Chen S, Pang GZ, Yong L, Ding Z, Shen YJ, Shen YX*, Shao W*. LncRNA Gm26917 reguates inflammatory response in macrophages by enhancing Annexin A1 ubiquitination in LPS-induced acute liver injury. Frontiers in 藥理學(xué) 2022, 13:975250 (IF=5.6).
13. Li H, Wu ZS, Zhong RL, Zhang QK, Chen QX, Shen YX*. PRDX6 knockout restrains the malignant progression of intrahepatic 膽管癌Med Oncol. 2022 Oct 8;39(12):250.（IF=3.738）
14. Ren CP#, Gao Y#, Zhang C#, Zhou C, Hong Y, Qu MS, Zhao ZR, Du YN, Yang L, Liu BY, Wang SY, Han MF*, Shen YX*, Liu Y*. Respiratory Mucosal Im-munity: Kinetics of Secretory Immunoglobulin A in Sputum and Throat Swabs From COVID-19 Patients and Vaccine Recipients. Front Microbiol 2022, 13: 782421.（IF=6.064）
15. Song MM*, Chen J, Ye SM, Lu DP, Zhang GY, Liu R, Shen YX*. Targeted de-livery of edaravone by liposomes for the treatment of ischemic stroke. Nano藥品 2022,https://doi.org/102217/nnm-2021-0490.（IF=5.5）
16. Wang P, Yang Y, Pang GZ, Zhang CY, Wei CS, Tao XF, Liu J, Xu JM, Zhang WP*, Shen YX*. Hepatocyte-derived MANF is protective for 利福平induced cholestatic hepatic injury via inhibiting ATF4-CHOP signal activation. Free Radic Biol Med 2021, 162:283-297 (IF=6.17).
17. Yang Y, Wang P, Zhang CY, Huang F, Pang GZ, Wei CS, Lv CM, Chhetri G, Jiang TC, Liu J, Shen YJ, Shen YX*. Hepatocyte-derived MANF alleviates he-patic ischemia-reperfusion injury via regulating endoplasmic reticulum 應(yīng)力- in-duced apoptosis in 鼠科 Liver Int 2021, 41 (3): 623-639 (IF=5.175).
18. Hou C#, Mei Q#, Song XG, Bao Q, Li X, Wang D, Shen YX*. Mono-macrophage-Derived MANF Protects Against 脂多糖Induced Acute 腎臟 Injury via Inhibiting Inflammation and Renal M1 Macrophages. Inflammation 2021, 44 (2): 693-703 (IF=5.1).
19. Liu J#, Wu ZS#, Han D, Wei CS, Liang YY, Jiang TC, Chen L, Sha MQ, Cao YJ, Huang F, Gen.G XP, Yu JS, Shen YJ, Wang H, Feng LJ, Wang D, Fang SY, Wang SY*, Shen YX*. MANF inhibits liver cancer via SUMOylation-related suppres-sion of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition. Hepatology 2020, 71(4):1262-1278 (IF=17.425).
20. Chhetri G, Liang YY, Shao JT, Han D, Yang Y, Hou C, Wang P, Tao XF, Shen YJ, Jiang TC, Feng LJ, Shen YX*. Role of Mesencephalic Astrocyte-Derived Neu-rotrophic Factor in 乙醇Induced Liver Injury. Oxid Med Cell Longev 2020, 2020: 9034864 (IF=5.076).
21. Ma YY, Di ZM, Cao Q, Xu WS, Bi SX, Yu JS, Shen YJ, Yu YQ, Shen YX*, Feng LJ*. Xanthatin induces glioma cell apoptosis and inhibits tumor growth via acti-vating endoplasmic reticulum 應(yīng)力-dependent CHOP pathway. Acta Pharmacol Sin 2020, 41: 404-414 (IF=4.01).
22. Zhang N#, Shen YJ#, Pang GZ, Chu SY, Han W, Mei Q, Hu XL, 越南盾 FQ, Shen YX*, Zhao TT*. Ratiometric fluorescent nano-sensor for dosage-sensitive visu-al discrimination of glucose based on electron transfer mechanism. Microchem J 2020, 158: 105188 (IF=5.304).
23. Shao JT*, Zaro J, Shen YX*. Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intra細(xì)胞ular Fate. Int J Nanomedi-cine 2020, 15:9355–9371 (IF=6.4).
24. Xu RY, Pang GZ, Zhao Q, Yang L, Chen S, Jiang L, Shen YX*, Shao W*. The momentous role of N6‐methyladenosine in lung cancer. J Cell Physiol 2020, 236(5): 3244-3256 (IF=6.513).
25. Fei MY#, Song MM#, Wang P, Pang GZ, Chen J, Lu DP, Liu R, Zhang GY, Zhao TT, Shen YX*, Yu YQ*. Folic acid modified 四氧化三鐵 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging. RSC Adv 2020, 10(9), 5294-5303 (IF=3.361).
26. Xu SC, Di ZM, He YF, Wang RJ, Ma YY, Sun R, Li J, Wang T, Shen YJ, Fang SY, Feng LJ*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ 毒性 via attenuating Aβ-induced endoplasmic re-ticulum stress, J Neuroinflammation 2019, 16(1):35.
27. Hou C#,Wang D#, Li X, He YF, Wei CS, Jiang R, Liu J , Feng LJ, Shen YX*. MANF regulates splenic macrophage differentiation in 鼠科 Immunol Lett 2019, 212: 37-45.
28. Shi TL, Zhang L, 成姓 QY, Yu JS, Liu J, Shen YJ, Feng XJ, Shen YX*. Xan-thatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells. Eur J Pharmacol 2019, 843: 1–11.
29. Feng LJ#, Murugan M#, Bosco DB, Liu Y, Peng JY, Worrell GA, Wang HL, Ta LE, Richardson JR, Shen YX*, Wu LJ*. Microglial Proliferation and Monocyte Infiltration Contribute to Microgliosis following Status Epilepticus, Glia 2019, 67(8): 1434-1448.
30. Xiang HH#, Song MM#, Fei MY, Wang RJ, Tao XF, Shen YX*, Yu YQ*. Facile synthesis of multifunctional nanocomposites with good compatibility for efcient dual mode T1 and T2 magnetic 共振 imaging and gene delivery. Appl Na-nosci 2019, 9(8): 2019-2030.
31. He KW, Li JJ, Shen YX*, Yu YQ*. pH-Responsive 聚電解質(zhì) coated 釓 氧化物doped mesoporous silica nanoparticles (GdO@MSNs) for synergis-tic drug delivery and magnetic 共振 imaging enhancement, J Mater Chem B 2019, 7(43): 小行星68406854.
32. Bi SX, Li XH, Wei CS, Xiang HH, Shen YX*, Yu YQ*. The antitumour growth and antiangiogenesis effects of xanthatin in murine glioma dynamically evaluated by dynamic contrast‐enhanced magnetic 共振 imaging. Phytother Res 2019, 33(1): 149-158.
33. Wu J, Wang H, Li Q, Guo QY, Tao SQ, Shen YX*, Wu ZS*. The oncogenic im-pact of RNF2 on cell proliferation, invasion and migration through EMT on mammary carcinoma. Pathol Res Pract. 2019; 215 (9): 152523.
34. Wang D, Hou C, Cao YJ, 成姓 QY, Zhang L, Li H, Feng LJ, Shen YX*. XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF 助催化劑 region in hepatitis B. Int J Bio-chem Cell Biol 2018, 99: 140-146.
35. Song MM, Xiang HH, Fei MY, Lu DP, Jiang TC, Yu YQ, Liu R*, Shen YX*. Facile fabrication of H?Odispersible nanocomposites based on hexa-peri-hexabenzocoronene and 四氧化三鐵 for dual mode imaging (fluorescent/MR) and drug delivery. RSC Adv 2018, 8(71): 40554-40563.
36. Wang CH, Jiang TC, Qiang WM, Zhang L, Feng LJ, Shen YJ, Shen YX*. Acti-vator protein 1 is a novel regulator of mesencephalic astrocyte derived neu-rotrophic factor tranion. Molecular Medicine Reports 2018, 18(5): 5765-5774.
37. Feng LJ, Zhang J, Zhu N, Ding Q, Zhang XJ, Yu JS, Qiang WM, Zhang ZT, Ma YY, Huang DK, Shen YJ, Fang SY, Yu YF, Wang HP, Shen YX*. Ubiqui-tin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z vari- ant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy 2017, 13(4):686702.
38. Zhang WP, Chen LH, Feng H, Wang W, Cai Y, Qi F, Tao XF, Liu J, Shen YJ, Ren XF, Chen X, Xu JM*, Shen YX*. 利福平induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and en-hancing the Nrf2-mediated adaptive response. Free Radic Biol Med 2017,112: 24-35.
39. Zhang D, Li MM, 越南盾 Y, Zhang XH, Liu XY, Chen ZM, Zhu YJ, Wang HM, Liu XW, Zhu JL, Shen YJ, Korner H, Ying SC*, Fang SY* and Shen YX*. 1α, 25-Dihydroxyvitamin D3 up-regulates IL-34 expression in shSY5Y neural cells. Innate Immun 2017, 23(7): 584-591.
40. Song MM*, Xu HL, Liang JX, Xiang HH, Liu R, Shen YX*. Lactoferrin modi-fied graphene 氧化物 iron oxide nanocomposite for glioma-targeted drug delivery. Mater Sci Eng C Mater Biol Appl 2017, 77: 904-911.
41. Liu J, Tao XF, Zhang J, Wang P, Sha MQ, Ma Y, Geng XP, Feng LJ, Shen YJ, Yu YF, Wang SY, Fang SY, Shen YX*. Small ubiquitin-related modifier 1 is in-volved in hepatocellular carcinoma progression via mediating p65 nuclear translo-cation. Oncotarget 2016, 7(16): 22206-22218.
42. Wang XY, Song MM, Bi SX, Shen YJ, Shen YX*, Yu YQ*. MRI Dynamically Evaluates the Therapeutic Effect of Recombinant Human MANF on Ischemia/ReperfusionInjury in 家鼠屬 Int J 摩爾 Sci 2016, 17(9): 1476.
43. Fang WJ, Han C, Zhang HB, Wei WM, Liu R, Shen YX*. Preparation of 氨基functionalized magnetic nanoparticles for enhancement of bacterial capture ef-ficiency. RSC Adv 2016, 6(72): 67875-67882.
44. Chen LJ, Feng LJ, Wang X, Du J, Chen Y, Yang W, Zhou CY, 成姓 L, Shen YJ, Fang SY, Li J*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Sci Rep 2015, 5: 8133.
45. Liu J, Sha MQ, Wang QF, Ma Y, Geng XP, Gao YF, Feng LJ, Shen YJ, Shen YX*. Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. BMC Cancer 2015, 15: 675.
46. Liu J, Zhou CY, Tao XF, Feng LJ, Wang X, Chen LJ, Li CJ, Huang DK, Fang SY, Shen YX*. ER 應(yīng)力inducible protein MANF selectively expresses in human spleen. Hum Immunol 2015, 76(11): 823-830.
47. Chen LJ, Wan LJ, Du J*, Shen YX*. Identification of MANF as a protein inter-acting with RTN1-C. Acta Biochim Biophys Sin (Shanghai) 2015, 47(2): 91-97.
48. Yang W, Shen YJ, Chen Y, Chen L, Wang L, Wang HP, Xu SC, Fang SY, Fu Y, Yu YQ*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor pre-vents neuron loss via inhibiting ischemia-induced apoptosis. J Neurol Sci 2014, 344 (1-2): 129-138.
49. Wang LK, Tang WX, Jiang TC, Lu P, Li YH, Sun AM, Shen YJ, Chen Y, Wang HP, Zong ZJ, Wang YQ, Chen LJ, Shen YX*. Endoplasmic Reticulum 應(yīng)力 is involved in the Neuroprotective Effect of Propofol. Neurochem Res 2014; 39(9):1741-1752.
50. Wang JJ, Chen QY, Wang X, Zu BB, Xu JH, Xu YH, 左姓 XB, Shen YJ, Wang J, Shen YX*. Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus. Am J Med Sci 2014, 348(6): 465-473.
51. Chen ZM, Zhu MY, Pan X, Zhu YJ, Yan H, Jiang TC, Shen YJ, 越南盾 XW, Zheng N, Lu JS, Ying SC*, Shen YX*. Inhibition of 肝炎 B 病毒 replication by SAMHD1. Biochem Biophys Res Commun 2014, 450(4): 1462-1468.
52. Feng LJ, Jiang TC, Zhou CY, Yu CL, Shen YJ, Li J*, Shen YX*. Activated mac-rophage-[like] synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in 抗原induced 關(guān)節(jié)炎 Inflamm Res 2014; 63(5): 335-346.
53. Wang L, Chen L, Wang QF, Wang LJ, Wang HB, Shen YJ, Li XH, Fu Y, Shen YX*, Yu YQ*. Circulating endothelial progenitor cells are involved in VEGFR-2-related endothelial differentiation in glioma. Oncol Rep 2014, 32(5): 2007-2014.
54. Chen ZL, Zhong YW, Wang Y, Xu S, Liu Z, Baskakov IV, Monteiro MJ, Kar-bowski M*, Shen YX*, Fang SY*. Ubiquitination-Induced 熒光 Com-plementation (UiFC) for Detection of K48 Ubiquitin Chains In Vitro and in Live Cells. PLoS One 2013, 8(9): e73482.
55. Shen YJ#, Sun AM#, Wang YH, Cha DQ, Wang HP, Wang FC, Feng LJ, Fang SY*, Shen YX*. Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation 2012, 9: 254.
56. Shen YX*, Sun AM, Fang S, Feng LJ, Li Q, Hou HL, Liu C, Wang HP, Shen JL, Luo J, Zhou JN*. Hrd1 Facilitates Tau Degradation and Promotes Neuron Sur-vival. Curr 摩爾 Med 2012, 12(2): 138-152.
57. Wang HP, Li Q, Shen YJ, Sun AM, Zhu XG, Fang SY, Shen YX*. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and in-creases its 溶解度 摩爾 Cell Biochem 2011, 346(1-2): 137-145.
58. Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, Zhang JJ, Shen YJ, Wang HP, Fang S, Shen YX*. Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. J Cereb Blood Flow Metab 2010, 30(1): 79-91.
59. Feng LJ, Shen YX*, Sun AM, Shen YJ, Fang SY, Li J*. Endoplasmic reticulum stress is involved in okadaic acid-induced tau phosphorylation and neurotoxic ef-fects of okadaic acid. Neural Regen Res 2010, 5(20): 1534-1540.
60. Yue L, Shen YX*, Feng LJ, Liu LH, Chen FH, Wu Q, Wang Hua. Blockage of the formation of new blood vessels by recombinant human endostatin contributes to the regression of rat adjuvant 關(guān)節(jié)炎 Eur J Pharmacol 2007, 567(1-2): 166-170.
61. Shen YX, Ballar P, Apostolou A, Doong H, Fang SY. ER stress differentially reg-ulates the stabilities of ERAD ubiquitin ligases and their substrates. Biochem 閉姓ophys Res Commun 2007, 352(4): 919-924.
62. Shen YX*, Zhang GG, Liu LH, Wang H, Xu SY. Suppressive of effects of 墨爾本atonin on amyloid ? peptide-induced glial activation in rat hippocampus. Arch Med Res 2007, 38(3): 284-290.
63. Shen YX, Ballar P, Fang SY*. Ubiquitin ligase gp78 increases 溶解度 and fa-cilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem Biophys Res Commun 2006, 349(4): 1285-1293.
64. Yue L, Wang H, Liu LH, Shen YX*, Wei W*. Anti-adjuvant 關(guān)節(jié)炎 of recom-binant human endostatin in rats via inhibition of angiogenesis and proinflamma-tory factors. Acta Pharmacol Sin 2004; 25(9): 1182-1185.
65. Shen YX*, Xu SY, Wei W, Sun XX, Liu LH, Yang J, Dong C. The protective ef-fects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged 家鼠屬 J Pineal Res 2002, 32(2): 85-89.
66. Shen YX*, Xu SY, Wei W, Wang XL, Wang H, Sun X. Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35. J Pineal Res 2002, 32(3): 163-167.
67. Shen YX*, Xu SY, Wei W, Sun XX, Yang J, Liu LH, Dong C. Melatonin reduces memory changes and neural oxidation damage in mice treated with D-galactose. J Pineal Res 2002; 32(3): 173-178.
68. Shen YX*, Wei W, Xu SY. Protective effects of melatonin on the cortical -hippocampal neurotoxicity induced by amyloid beta-peptide 25-35. Acta Phar-macol Sin 2002, 23(1): 71-76.
69. Shen YX*, Wei W, Yang J, Liu C, Dong C, Xu SY. Improvement of melatonin to learning and memory impairment induced by amyloid ?-peptide 25~35 in elder 家鼠屬 Acta Pharmacol Sin 2001, 22(9): 797-803.
參考資料：
社會(huì)職務(wù)
沈玉先任中國(guó)藥理學(xué)會(huì)抗炎免疫專業(yè)委員會(huì)委員、世界中醫(yī)藥學(xué)會(huì)聯(lián)合會(huì)中醫(yī)藥免疫專業(yè)委員會(huì)常務(wù)理事、安徽省藥理學(xué)會(huì)常務(wù)理事、安徽省色譜學(xué)會(huì)常務(wù)理事；沈玉先還任Journal of Pharmacological Science編委、中國(guó)藥理學(xué)通報(bào)編委、安徽醫(yī)科大學(xué)學(xué)報(bào)編委；沈玉先還是NatComm、FreeRadicalBioMed、BrainBehaviorandImmunity、SciRep等10余種SCI源期刊的審稿人。
參考資料：
主要成就
2000年獲第四屆中國(guó)藥理學(xué)學(xué)會(huì)Servier青年藥理學(xué)工作者獎(jiǎng)；
2003年入選安徽省拔尖人才；
2004年入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”；
2005年獲中國(guó)博士后基金一等資助；
2006年入選安徽省學(xué)術(shù)科技帶頭人；
2007年獲安徽省人才開發(fā)基金資助；
2014年安徽省科學(xué)技術(shù)獎(jiǎng)（科技進(jìn)步類）二等獎(jiǎng)（第三完成人）；
2019年安徽省科學(xué)技術(shù)獎(jiǎng)（自然科學(xué)類）一等獎(jiǎng)（第一完成人）；
2019 年第五屆互聯(lián)網(wǎng)+大學(xué)生創(chuàng)新創(chuàng)業(yè)大賽全國(guó)銅獎(jiǎng)、安徽省金獎(jiǎng) (指導(dǎo)教師)；
2015年安徽省科學(xué)技術(shù)獎(jiǎng)（科技進(jìn)步類）二等獎(jiǎng)（第二完成人）；
2022年9月，被安徽省委教育工委、省教育廳確定為2022年度“全省教書育人楷模”。
參考資料 >
沈玉先.安徽醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院.2024-09-16