孔祥銀，男，1988年畢業于山東醫科大學醫學系，獲學士。中國科學院上海生命科學研究院研究員、博導。2002年至今任中國科學院上海生命科學研究院/上海交通大學醫學院健康科學研究所研究員，博士生導師，課題組長。孔祥銀研究員主要研究方向為分子遺傳學·
人物經歷
1983年9月-1988年7月，孔祥銀就讀于山東醫科大學醫學系，畢業獲得醫學學士學位。
1988-1995年中國醫學科學院血液學研究所先后任研究實習員，助理研究員，期間1992-1993年于協和醫科大學研究生院在職研究生學習；
1995-1997年馬克斯·普朗克分子遺傳學研究所訪問學者；
1997—2002年中科院上海生物工程研究中心工作，先后任助理研究員，副研究員，研究員
主要成果
成功克隆了遺傳性牙本質發育不全Ⅰ型基因(DSPP)，并發現該基因的部分突變還引起進行性高頻耳聾，證實了DSPP不僅參與牙本質的發育，特別是牙本質的礦化過程，還參與了聽覺系統的發育，建立了牙齒發育和內耳發育之間的聯系。從而為闡明相關疾病的發生機制奠定了基礎，開辟了新的思路。研究論文發表在2001《Nature Genetics》；成功克隆了遺傳性兒童性白內障的致病基因熱休克蛋白轉錄因子4(HSF4)；在國際上首次發現熱休克蛋白轉錄因子是導致遺傳性兒童性白內障的致病基因，發現HSF4蛋白脫氧核糖核酸結合區在白內障發生中具有重要作用，首次將熱休克蛋白的合成與白內障的發生聯系起來為該病的診斷和治療提供了新的理論依據，加深了對白內障發生的分子機理認識。
研究論文發表在2002《Nature Genetics》；在國際上首次發現CYLD突變引起遺傳性毛發上皮瘤；首次發現CYLD基因的不同突變突變引起遺傳性毛發上皮瘤，研究結果于2002年上海市HGM2002會議公布，論文發表于2004年《Human Mutation》。
主要論文
（1）Global analysis of T-cell groups reveals immunological features and common 抗原 targets of digestive tract tumors, Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors, J Cancer Res Clin Oncol, 2024.
（2）Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop, Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop, Adv Sci (Weinh), 2024, 第6作者.
（3）Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation, Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation, Nat Immunol, 2024, 第12作者.
（4）Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis, Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16一級方程式錦標賽 tumor and single-細胞 analysis, STAR Protoc, 2023.
（5）A novel long noncoding 核糖核酸 SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3, A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3, Cell Death Differ, 2023, 第6作者.
（6）Single-細胞 核糖核酸 sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity, Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity, iScience, 2023.
（7）Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases, Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases, Heliyon, 2023.
（8）Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Stem Cell Reports, 2023, 第12作者.
（9）Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral T reg cell differentiation, NATURE IMMUNOLOGY, 2023, 第 20 作者.
（10）Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex, Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex, Cell Rep, 2023, 第12作者.
（11）Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors, Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3K inhibitors, Signal Transduct Target Ther, 2023, 第12作者.
（12）Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals, Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals, J Allergy Clin Immunol, 2022, 第12作者.
（13）Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma, Genome-wide gain-of-函數 screening identifies EZH2 mediating resistance to PI3K inhibitors in oesophageal squamous cell carcinoma, Clin Transl Med, 2022, 第12作者.
（14）SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes, SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes, Adv Sci (Weinh), 2022, 第12作者.
（15）Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR, Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR, PLoS Biol, 2022, 第12作者.
（16）Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation, Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation, mSystems, 2021.
（17）PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism, PI3K inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid 新陳代謝, J Immunother Cancer, 2021.
（18）Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Adaptive resistance to PI3K-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Cell Death Dis, 2021, 第12作者.
（19）CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis, CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis, Theranostics, 2021, 第12作者.
（20）Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer, Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer, Commun Biol, 2021.
（21）Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma, Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma, Front Cell Dev Biol, 2021, 第12作者.
（22）Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, Cell 死亡 Dis, 2020, 第12作者.
（23）Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, front Genet, 2020.
（24）Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, CELL DEATH & DISEASE, 2020, 第11作者.
（25）Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第12作者.
（26）Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, FRONTIERS IN GENETICS, 2020, 第10作者, 通訊作者.
（27）Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer, Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer, Biochim Biophys Acta Mol Basis Dis, 2020.（28）Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, Proc Natl Acad Sci U S A, 2020, 第12作者.
（29）ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression, SCIENTIFIC REPORTS, 2019, 第8作者, 通訊作者.
（30）Sex-related 脫氧核糖核酸 methylation differences in B cell chronic lymphocytic 白血病, BIOLOGY OF SEX DIFFERENCES, 2019, 第5作者.
（31）A computational method using the random walk with restart algorithm for identifying novel epigenetic factors, MOLECULAR GENETICS AND GENOMICS, 2018, 第5作者, 通訊作者.
（32）Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine, BBA - MOLECULAR BASIS OF DISEASE, 2018, 第5作者.
（33）Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2018, 第5作者, 通訊作者.
（34）Identification of the core regulators of the HLA I-peptide binding process, SCIENTIFIC REPORTS, 2017, 第7作者, 通訊作者.
（35）Identifying and analyzing different cancer subtypes using 核糖核酸seq data of blood platelets, ONCOTARGET, 2017, 第8作者 通訊作者.
（36）Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach, COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2015, 第7作者, 通訊作者.
（37）Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations, SCIENTIFIC REPORTS, 2015, 第14作者.
（38）Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma, JOURNAL OF GENETICS AND GENOMICS, 2015, 第12作者.
（39）Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network, HINDAWI PUBLISHING CORPORATION, 2015, 第1作者.
（40）Alternative splicing at GYNNGY 5 splice sites: more noise, less regulation, NUCLEIC ACIDS RESEARCH, 2014, 第10作者, 通訊作者.
（41）COL4A3 mutations cause focal segmental glomerulosclerosis, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第14作者.
（42）Exome sequencing identifies frequent mutation of MLL2 in non small cell lung carcinoma from Chinese patients, SCIENTIFIC REPORTS, 2014, 第15作者.
（43）Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving, MOLECULAR BIOLOGY AND EVOLUTION, 2013, 第11作者.
（44）Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study, SCIENTIFIC REPORTS, 2013, 第6作者, 通訊作者.
（45）Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases, PLOS GENETICS, 2011, 第11作者.
（46）SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 第8作者.
（47）Evidence for OTUD-6B Participation in B Lymphocytes Cell Cycle after 細胞因子 Stimulation, PLOS ONE, 2011, 第 4 作者
（48）Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation, MOLECULAR SYSTEMS BIOLOGY, 2010, 第9作者, 通訊作者.
（49）Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features, PLOS ONE, 2010, 第5作者.
（50）Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, 細胞研究：英文版, 2010, 第14作者.
（51）Loss-of-函數 Mutations in the PRPS1 Gene Cause a Type of Nonsyndromic X-linked Sensorineural Deafness, DFN2, AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 第11作者.
（52）Identification of vimentin as a novel target of hsf4 in lens development and cataract by proteomic analysis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 第7作者.
（53）Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury, LABORATORY INVESTIGATION, 2009, 第9作者.
（54）Gain-of-Function Mutation of KIT 配體 on Melanin Synthesis Causes Familial Progressive Hyperpigmentation, AMERICANJOURNALOFHUMANGENETICS, 2009, 第15作者, 通訊作者.
（55）Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay, BMC BIOLOGY, 2009, 第6作者, 通訊作者.
（56）Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals, GENOME BIOLOGY, 2009, 第7作者.
（57）Divergence of exonic splicing elements after gene duplication and the impact on gene structures, GENOME BIOLOGY, 2009, 第7作者, 通訊作者.
（58）Removal of Hsf4 leads to 白內障 development in mice through down-regulation of gamma S-crystallin and Bfsp expression, BMC MOLECULAR BIOLOGY, 2009, 第8作者, 通訊作者.
（59）Triphalangeal Thumbpolysyndactyly 綜合征 and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer, JOURNAL OF MEDICAL GENETICS, 2008.
（60）Alternative Promoters Influence Alternative Splicing at the Genomic Level, PLOS ONE, 2008, 第3作者.
（61）Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes, GENOME BIOLOGY, 2008, 第6作者, 通訊作者.
（62）Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines, CELL RESEARCH, 2007, 第8作者.
（63）Association of IL4R gene polymorphisms with asthma in Chinese populations, Hum Mutat, 2007, 第1作者, 通訊作者.
（64）Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies, HUMAN MOLECULAR GENETICS, 2006.
（65）Simple sequence repeat-based consensus linkage map of Bombyx mori, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005.
（66）Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor, HUMAN 病理學, 2005.
（67）CYLD Mutation Causes Multiple Familial Trichoepithelioma in Three Chinese Families, HUMAN MUTATION, 2004, 第10作者, 通訊作者.
（68）Molecular evolution of the 嚴重急性呼吸綜合征 正冠狀病毒亞科 during the course of the sars epidemic in china, SCIENCE, 2004.
（69）Embryonic stem cells generated by nuclear transfer of human somaticnuclei into rabbit oocytes, Embryonic stem cells generated by nuclear transfer of human somatic nuclei into 兔形目 oocytes, CELL RESEARCH, 2003.
（70）Mutant 脫氧核糖核酸binding domain of HSF4 is associated with autosomal dominant lamellar and Marner 白內障, NATURE GENETICS, 2002.
（71）Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP (vol 27, pg 201, 2001), NATURE GENETICS, 2001.
注：資料來源
榮譽
孔祥銀研究員曾獲國家自然科學二等獎，上海市科技進步二等獎，上海市科技進步一等獎， 2004年獲第八屆中國青年科技獎，以及第八屆中國科學院十大杰出青年，2006年獲上海市領軍人才稱號。
參考資料 >
孔祥銀.中國科學院大學.2024-10-29