盧宇靖，男，博士，教授，博士生導師，1980年3月生，新會區人。現任廣東工業大學生物醫藥學院副院長，同時任職于廣東工業大學天然藥物與綠色化學研究所、廣東省藥食同源綜合利用與研究開發工程中心，以及Allan H. Conney新藥研發聯合實驗室。2012年入選廣東省高等學校“千百十工程”校級培養對象和廣東工業大學“培英育才”人才計劃培養對象。曾獲廣東省科學技術獎一等獎、教育部自然科學獎二等獎、廣東省輕工業協會科技進步獎一等獎、廣東工業大學先進科技工作者等榮譽稱號。
人物經歷
教育經歷
- 2008-2010 香港理工大學應用生物與化學技術系、手性科學國家重點實驗室（博士后）
- 2003-2008 中山大學藥學院藥物化學專業（碩博連讀）（理學博士）
- 1999-2003 中山大學化工學院應用化學（理學學士）
工作經歷
- 2016-至今 廣東工業大學 教授
- 2011-2016 廣東工業大學 副教授
- 2010-2011 廣東工業大學 講師
科研成果
主要榮譽
廣東工業大學2011年優秀科技工作者。
第七批廣東省“千百十”校級培養對象。
2011年廣東工業大學“培英育才”（科研類第二層次）培養對象。
2011年廣東省科學技術獎勵一等獎.
主要論文
1. Yuan-Yuan Zheng, Ruo-Lan Du, Sen-Yuan Cai, Zhi-Hua Liu, Zhi-Yuan Fang, Ting Liu, Lok-Yan So, Yu-Jing Lu*, Ning Sun and Kwok-Yin Wong. Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ. Frontiers in Microbiology, 2018, 9, 1937. （SCI 2區）
2. Wei Long, Yu-Jing Lu*, Kun Zhang, Xuan-He Huang, Jin-Qiang Hou, Sen-Yuan Cai, Ying Li, Xian Du, Leonard G. Luyt, Wing-Leung Wong, Cheuk-Fai Chow. Boosting the turn-on fluorescent signaling ability of 噻唑 orange dyes: The effectiveness of structural modification site and its unusual interaction behavior with nucleic acids. Dyes and Pigments 159 (2018) 449–456.（SCI 2區）
3. Cong Wang, Yu-Jing Lu,?, Sen-Yuan Cai, Wei Long, Yuan-Yuan Zheng, Jing-Wen Lin, Yan Yan, Xuan-He Huang, Wing-Leung Wong, Kun Zhang, Cheuk-Fai Chow. Advancing small ligands targeting 核糖核酸 for better binding affinity andspecificity: A study of structural influence through molecular 設計 approach. Sensors and Actuators B: Chemical, 262, 2018, 386-394. （SCI 1區）
4. Yu-Jing Lu*, Xiao-Lu Guo, Miao-Han Xu, Wei-Wu Chen, Cheuk-Fai Chow. Selective visualization of 脫氧核糖核酸 G-quadruplex structures in live cells with 1-methylquinolinium-based molecular probes: The importance of indolyl moiety position towards specificity. Dyes and Pigments, 143, 2017, 331-341. （SCI 2區）
5. Sun N, Du RL, Zheng YY, Huang BH, Guo Q, Zhang RF, Wong KY, Lu Yu-Jing*. Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. European Journal of Medicinal 化學 135, 2017, 1-11. （SCI 2區）
6. Ning Sun, Cong Wang, Miao-Han Xu, Yu-Jing Lu*, Cheuk-Fai Chow. The interaction of a structural flexible small molecule with nucleic acid structures: Investigation of the origin of fluorescence signal discrimination in sensing and the utilization in live cell imaging. Sensors and Actuators B: Chemical, 250, 2017, 543-551. （SCI 2區）
7. Yu-Jing Lu*, 越南盾Ping Hu, Kun Zhang, Wing-Leung Wong, Cheuk-Fai Chow. New pyridinium-based fluorescent dyes: A comparison of symmetry and side-group effects on G-Quadruplex 脫氧核糖核酸 binding selectivity and application in live cell imaging. Biosensors and Bioelectronics, 81, 2016, 373-381. （SCI 1區）
8. Yu-Jing Lu*, Qiang Deng, Jin-Qiang Hou, 越南盾Ping Hu, Zheng-Ya Wang, Kun Zhang, Leonard G. Luyt, Wing-Leung Wong, and Cheuk-Fai Chow. Molecular Engineering of 噻唑 Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay. ACS Chemical Biology, 2016, 11, 1019-1029. （SCI 2區）
9. Yu-Jing Lu*, Qiang Deng, 越南盾Ping Hu, Zheng-Ya Wang, Bao-Hua Huang, Zhi-Yun Du, Yan-Xiong Fang, Wing-Leung Wong, Kun Zhang and Cheuk-Fai Chow, A molecular fluorescent dye for specific staining and imaging of 核糖核酸 in live cells: a novel ligand integration from classical 噻唑 orange and styryl compounds. Chem. Commun., 2015, 51, 15241-15244.（SCI 2區）
10. Yu-Jing Lu*, 越南盾Ping Hu, Qiang Deng, Zheng-Ya Wang, Bao-Hua Huang, Yan-Xiong Fang, Kun Zhang and Wing-Leung Wong, Sensitive and selective detection of 尿嘧啶脫氧核糖核酸 glycosylase activity with a new pyridinium luminescent switch-on molecular probe. Analyst, 2015,140, 5998-6004.（SCI 2區）
11. Yu-Jing Lu*, Zheng-Ya Wang, 越南盾Ping Hu, Qiang Deng, Bao-Hua Huang, Yan-Xiong Fang, Kun Zhang, Wing-Leung Wong, Cheuk-Fai Chow. Benzo噻唑substituted benzofuroquinolinium dyes as new fluorescent probes for G-quadruplex 脫氧核糖核酸 Dyes and Pigments, 2015, 122, 94–102.（SCI 2區）
12. Yu-Jing Lu, Wing-Leung Wong, Cheuk-Fai Chow, A surfactant-like ionic liquid with permanganate dissolved as a highly selective epoxidation system. Catalysis Communications, 2015, 69, 25–28.（SCI 3區）
13. Jiaqiang Liu, Chang Sun, Wenliang Ma, Yu-Jing Lu, Lin Yu, Kun Zhang and Huaqiang Zeng, A conformationally switchable fluorescent oligophenol foldamer for selective sensing of 銅(II) ions. RSC Advances, 2014, 4, 54469-54473.
14. Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY. Rational 設計 of 小檗堿-based FtsZ inhibitors with broad-spectrum antibacterial activity. PLoS One. 2014, 13, 9(5): e97514.
15. Wang HQ, Li DL, Lu YJ, Cui XX, Zhou XF, Lin WP, Conney AH, Zhang K, Du ZY, Zheng X. Anticancer activity of Acanthopanax trifoliatus (L) Merr extracts is associated with inhibition of NF-kB activity and decreased Erk1/2 and Akt phosphorylation. Asian Pac J Cancer Prev. 2014; 15(21):9341-6.
16. Yue Wu, Li-Peng Zan, Xiao-越南盾 Wang, Yu-Jing Lu, Tian-Miao Ou, Jing Lin, Zhi-Shu Huang, Lian-Quan Gu, Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives. Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840, 2970–2977. （SCIⅡ區）
17. pan-Pan Wu , Kun Zhang, Yu-Jing Lu, Ping He, Su-Qing Zhao, In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives. European Journal of Medicinal 化學, 2014, 80, 502-508.
18. Chang Sun, Ying Liu, Jiaqiang Liu, Yu-Jing Lu, Lin Yu, Kun Zhang, and Huaqiang Zeng, Computational Insights into Processes Underlying the Amine-Induced Fluorescence Quenching of a Stimuli-Responsive Phenol-Based Hexameric Foldamer Host. J. Org. Chem., 2014, 79, 2963–2973.（SCIⅡ區）
19. Bin Qiu, Ya-shan zhang, Yi-bing Lin, Yu-Jing Lu, Zhen-yu Lin, Kwok-Yin Wong, Guo-nan Chen, A novel fluorescent biosensor for detection of target 脫氧核糖核酸 fragment from the transgene cauliflower mosaic 病毒 35S promoter. Biosensors and Bioelectronics, Volume 41, 15 March 2013, Pages 168–171. （SCI 1區）
20. Yi-Yong Yan, Jia-Heng Tan, Yu-Jing Lu, Siu-Cheong Yan, Kwok-Yin Wong, Ding Li, Lian-Quan Gu, Zhi-Shu Huang, G-Quadruplex conformational change driven by pH variation with potential application as a nanoswitch. BBA - General Subjects, 2013, 1830, 4935-4942. （SCIⅡ區）
21. Yu-Jing Lu, Na Ma, Yu-jun Li, Zhen-yu Lin, Bin Qiu, Guo-nan Chen, Kwok-Yin Wong. Styryl quinolinium/G-quadruplex complex for dual-channel fluorescent sensing of Ag+ and cysteine. Sensors and Actuators B, 2012, 173, 295– 299.（SCIⅡ區）
22. Yu-Jing Lu, Siu-Cheong Yan, Fung-Yi Chan, Lan Zou, Wai-Hong Chung, Wing-Leung Wong, Bin Qiu, Ning Sun, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu, and Kwok-Yin Wong. Benzo噻唑substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex. Chemical Communication. 2011, 47, 4971-4973.（SCIⅡ區）
23. Yu-Jing Lu, Tian-Miao Ou, Jia-Heng Tan, Jin-Qiang Hou, Wei-Yan Shao, Dan Peng, Ning Sun, Xiao-越南盾 Wang, Wei-Bin Wu, Xian-Zhang Bu, Zhi-Shu Huang, Dik-Lung Ma, Kwok-Yin Wong, Lian-Quan Gu. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation. Journal of Medicinal 化學, 2008, 51, 6381-6392.（SCIⅡ區）
24. Tian-Miao Ou, Jing Lin, Yu-Jing Lu, Jin-Qiang Hou, Jia-Heng Tan, Shu-Han Chen, Zeng Li, Yan-Ping Li, Ding Li, Lian-Quan Gu, Zhi-Shu Huang, Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex, Journal of Medicinal 化學, 2011, 54, 5671–5679.（SCIⅡ區）
25. Bin Qiu, Zhen-Zhu Zheng, Yu-Jing Lu, Zhen-Yu Lin, Kwok-Yin Wong, Guo-Nan Chen, G-quadruplex 脫氧核糖核酸zyme as the turn on switch for fluorimetric detection of genetically modified organisms, Chemical Communications, 2011, 47, 1437-1439.（SCIⅡ區）
26. Xiao-越南盾 Wang, Tian-Miao Ou, Yu-Jing Lu, Zeng Li, Zheng Xu, Lian-Quan Gu, Zhi-Shu Huang. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. Journal of Medicinal 化學, 2010, 53, 4390-4398.（SCIⅡ區）
27. Tian-Miao Ou, Yu-Jing Lu，Chi Zhang, Zhi-Shu Huang, Xiao-越南盾 Wang, Jia-Heng Tan, Yuan Chen, Dik-Lung Ma, Kwok-Yin Wong, Johnny Cheuk-On Tang, Albert Sun-Chi Chan , Lian-Quan Gu. Stabilization of G-quadruplex 脫氧核糖核酸 and down-regulation of oncogene c-myc by quindoline derivatives. Journal of Medicinal 化學, 2007, 50, 1465-1474. (Contributed equally with 1st author)（SCIⅡ區）
28. Jia-Heng Tan, Tian-苗族 Ou, Jin-Qiang Hou, Yu-Jing Lu, Shi-Liang Huang, Hai-Bin Luo, Jian-Yong Wu, Zhi-Shu Huang, Kwok-Yin Wong, Lian-Quan Gu, Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-Quadruplex 脫氧核糖核酸, Journal of Medicinal 化學, 2009, 52, 2825–2835.（SCIⅡ區）
29. Yu-Jing Lu, Ning Sun, Zhi Shu Huang, Lian Quan Gu. A rapid and efficient synthesis of indoloquinolinone and its analogues under microwave irradiation. Chinese Chemical Letters, 2008, 19, 518-520.
30. Tian-Miao Ou, Yu-Jing Lu, Jia-Heng Tan, Zhi-Shu Huang, Kwok-Yin Wong, Lian-Quan Gu. G-quadruplexes: targets in anticancer drug 設計 ChemMedChem, 2008, 3,690-713.
31. Qi-Biao Su , Fan He , Xue-Ding Wang , Su Guan , Zhi-Yong Xie , Lai-You Wang , Yu-Jing Lu , Lian-Quan Gu , Zhi-Shu Huang , Xiao Chen , Min Huang , Shu-Feng Zhou. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Investigational New Drugs. 2008, 26, 119-137.
32. Chi Zhang, Wei-Bin Wu, Yu-Jing Lu, Lian-Quan Gu, Zhi-Shu Huang. Molecular modeling studies of interactions between quindoline derivatives and G-quadruplex. Acta Chimica Sinica. 2008, 66, 953-958.
33. Yan Ma, Tian-Miao Ou, Jin-Qiang Hou, Yu-Jing Lu, Jia-Heng Tan, Lian-Quan Gu, Zhi-Shu Huang. 9-N-substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. Bioorganic & Medicinal 化學, 2008, 16, 7582-7591.
34. Jia-Heng Tan, Yu-Jing Lu, Zhi-Shu Huang, Lian-Quan Gu and Jian-Yong 吳語 Spectroscopic studies of 脫氧核糖核酸 binding modes of cation-substituted anthrapyrazoles derived from 大黃素 European Journal of Medicinal 化學, 2007, 42, 1169-1175.
35. Wan-Jin Zhang, Tian-Miao Ou, Yu-Jing Lu, Ying-Yu Huang, Wei-Bin Wu, Zhi-Shu Huang, Jin-Lin Zhou, Kwok-Yin Wong, and Lian-Quan Gu. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric 脫氧核糖核酸 Bioorganic & Medicinal 化學, 2007, 15, 5493-5501.
36. Qi-Biao Su , Fan He , Su Guan , Yu-Jing Lu , Lian-Quan Gu , Zhi-Shu Huang , Xiao Chen , Min Huang , Chun-Guang Li , Balram Chowbay , Shu-Feng Zhou. High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: Application to an enzyme kinetic study in rat liver microsomes. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2007, 854, 332-337.
37. J-M Zhou, X-F Zhu, Y-J Lu, R Deng, Z-S Huang, Y-P Mei, Y Wang, W-L Huang, Z-C Liu, L-Q Gu and Y-X Zeng. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503-511.
38. Jin-Lin Zhou, Yu-Jing Lu, Tian-Miao Ou, Jun-Min Zhou, Zhi-Shu Huang, Xiao-Feng Zhu, Cui-Juan Du, Xian-Zhang Bu, Lin Ma, Lian-Quan Gu, Yue-Ming Li, and Albert Sun-Chi Chan. Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase. Journal of Medicinal 化學, 2005, 48, 7315-7321.（SCIⅡ區）
知識產權
1、 黃玄賀 盧宇靖 蔡森源 李瑩 龍威 張焜 黃寶華，一種曲美他半抗原、人工抗原及其制備方法和應用 - 201810632217.2；
2、黃玄賀 盧宇靖 蔡森源 李瑩 龍威 黃寶華 張，西地那非半抗原、人工抗原及其制備方法 - 201810246409.X；
3、盧宇靖 李瑩 蔡森源 鄭園園 龍威 王聰，吲乙烯取代啉衍生物在制備抗耐藥菌藥物中的應用 - 201810463223.X；
4、蔡森源 盧宇靖 黃玄賀 李瑩 龍威 黃寶華 張焜，西地那非半抗原、人工抗原及其制備方法 - 201810247752.6；
5、龍威 張焜 盧宇靖 李瑩 杜現 王聰 蔡森源 鄭園園 林丹敏， 核酸染料化合物及其制備方法和應用 201810042612.5；
6、龍威 張焜 盧宇靖 王聰 蔡森源 鄭園園 林丹敏,化合物、其制備方法、熒光染料和熒光探針 - 201710771689.1；
7、盧宇靖 張焜 黃寶華 杜志云 莊子 雷琳 付成杰 胡冬萍 鄧強 王鄭亞。常山堿衍生物及其在制備抗耐藥菌藥物中的應用 - 201410168506.3;103980251B，授權；
8、張焜 付成杰 盧宇靖 鄧強 王鄭亞 胡冬萍 周小芬 杜志云 鄭希 黃寶華 方巖雄。一種苯并呋喃喹啉化合物作為雙功能pH探針的應用 - 201310536862.1;103575714B，授權；
9、盧宇靖 張焜 A·H·康尼 鄭希 張瑞瑞 杜志云 張瑞芳 付成杰 周代營 王華倩 方巖雄 趙肅清 黃寶華。一種苯胺基取代甲苯并呋喃喹啉衍生物及其制備方法和應用。申請號：201210117361.5，授權；
10、黃志紓 盧宇靖 李增 古練權 譚家恒。一種雙脂肪氨基取代吲哚喹啉衍生物及其制備方法和制備抗腫瘤藥物中的應用。申請號：201110093613.0；
11、黃志，古練權，盧宇靖，歐田苗。 一種脂肪氨基取代3-甲基吲哚喹啉衍生物及其制備方法和制備抗腫瘤藥物中的應用。 中國專利獎申請號：200810027094.6 ，授權。
科研項目
1.國家自然科學基金面上基金：耐藥菌特異性蛋白FtsZ新型抑制劑的發現與作用機理研究[65萬，2015.01-2018.12，主持]
2.廣東省農業廳農業科技創新項目：柑橘功能因子的生物酶法制備及其產業化應用關鍵技術研發，（2018LM2175）[50萬，2019.01.01-2019.12.31，主持]
3.國家自然科學基金青年基金：新型熒光探針MQ-TO 細胞內實時示蹤G-四鏈體DNA 行為的研究（21102021）[25萬，2012.01-2014.12，主持]
4.廣州市產學研協調創新重大專項：基于免疫膠體金技術的非法添加快篩試劑盒研發[100萬（到校30萬），2015-2017，合作單位主持]
5.廣東省自然科學基金博士啟動基金：噻唑取代吲哚喹啉熒光示蹤細胞內核酸G-四鏈體結構的研究（S2011040004201）[3萬，2011.10-2013.10，主持]
6.廣東工業大學“培英育才”（科研類）人才項目：基于天然產物開發抗腫瘤藥物的基礎研究[40萬，2012.5-2016.5，主持]
7.廣東省科技計劃攻關項目：抗球蟲藥常山酮全合成新工藝的開發研究（No.2012B020306007） [8萬，2012-2014，排名第二]
8.廣東省部產學研項目：三維仿組織腫瘤藥敏檢測試劑盒研制（2012B091100342）[30萬元，2012.09-2014.12，排名第三]
教學活動
盧宇靖教授主要從事制藥工程相關的專業課程教學，包括《專業英語》《藥物合成反應》《專業實驗》等課程的理論教學及實踐教學。
參考資料 >