鄭加麟（男，漢族），現任同濟大學醫學與生命科學部主任及醫學院院長。
教育經歷
1982年9月----1987年7月 徐州醫科大學 臨床醫學 學士
1987年9月----1990年7月 徐州醫學院和南京醫科大學 神經藥理學 碩士
1990年9月----1992年10月 上海交通大學醫學院 神經藥理學 博士生
工作經歷
19 92年10月-1993年3月
1993年3月-1996年7月
美國內布拉斯加大學醫學中心攻讀藥理學博士后
1996年7月-1997年5月
美國內布拉斯加大學醫學中心病理學和微生物學博士后研究員
1997年5月-1999年7月
美國內布拉斯加大學醫學中心病理學和微生物學系任講師
1997年5月至今
美國內布拉斯加大學醫學中心神經退行性疾病研究中心神經毒理學部主任
1999年7月-2003年6月
美國內布拉斯加大學醫學中心病理學、微生物學和藥理學助理教授
2000年9月至今
美國內布拉斯加病毒學研究中心（內布拉斯加大學林肯分校，內布拉斯加大學醫學中心和克雷頓大學）研究員
2002年1月-2007年7月
美國內布拉斯加大學醫學中心神經退行性疾病研究中心研究生教育部主任
2003年7月-2008年7月
美國內布拉斯加大學醫學中心病理學、微生物學、藥理學和實驗神經科學副教授（終身教授）
2004年9月-2007年1月
美國國立衛生研究院（nih） zrg1 ndbg 專家組成員
2004年9月-2007年12月
美國內布拉斯加大學醫學中心藥理學和神經實驗學系副主任
2004年
隨美國內布拉斯加州長mike johanns商務代表團訪問中國（翻譯和助手）
2005年至今
xpharm雜志（愛思唯爾 science出版社）副主編
2005年至今
美國內布拉斯加大學醫學中心亞太地區合作發展部（aprdp）主任
2005年3月
獲05年美國內布拉斯加大學醫學中心joseph p. gilmore杰出科研獎
2007年
隨美國內布拉斯加州長dave heineman商務代表團訪問中國（翻譯和助手）
2007年1月至今
美國國立衛生研究院（nih）“神經氧化代謝和凋亡研究”專家組常任成員
2007年7月至今
美國內布拉斯加大學醫學中心研究生院副院長（主管研究生教育和國際交流）
2008年7月至今
美國內布拉斯加大學醫學中心病理學、微生物學、藥理學和實驗神經科學教授（終身教授）
2010年12月起
同濟大學醫學與生命科學部主任
2023年6月
入選國家自然科學基金委員會公布2023年度醫學科學部基礎科學中心和創新研究群體項目專業評審組組成名單。
相關文獻
代表性科研論文(十篇)
1.whitney, n., peng, h., erdmann, n., tian, t, monaghan, d. and zheng, j. (2008). 鈣permeable ampa receptors containing q/r-unedited glur2 directs human neural progenitor cells differentiation to neurons. faseb j. (in press) (pmid: 18383342).
2.tian, c., erdmann, n., zhao, j., cao, z., peng, h. and zheng, j. (2008). hiv-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase. j. neurochem. 105: 994-1005 (pmid: 18088378)
3.peng, h. and whitney, n., wu, y, tian, t, dou, h, zhou, y and zheng, j. (2008). hiv-1-infected and/or immune-activated macrophage-secreted tnf-a affects human fetal cortical neural progenitor cell proliferation and differentiation. glia. 56 (8): 903-16 (pmid: 18403631).
4.cui, m., huang, y., zhao, y. and zheng, j. (2008). foxo3a transcription factor mediates cell 死亡 in hiv-1 infected macrophages. j. immunology. 180:898-906. (pmid: 18178829)
5.erdmann n, zhao j, lopez a, herek s, curthoys n, hexum t, tsukamoto t, ferraris d, zheng j. (2007). glutamate production by hiv-1 infected human macrophage is blocked by the inhibition of glutaminase. j. neurochem. 102:539-49. (pmid: 17596215)
6.huang, y., erdmann, n., peng, h., herek, s., davis, j., luo, x. t. ikezu, and j. zheng (2006). trail-mediated apoptosis in hiv-1-infected macrophages is dependent on the inhibition of akt-1 phosphorylation. j. immunology 177: 2304-2313. (pmid: 16887991)
7.zheng, j., 壯族, w., yan, n., kou, g., peng, h., mcnally, c., erichsen, d., cheloha, a., herek, s., shi, c. and shi, y. (2004). classification of hiv-1 mediated neuronal dendritic and synaptic damage using multiple criteria linear programming. neuroinformatics 2 (3): 303-26. (pmid: 15365193)
8.zheng, j., ghorpade, a., thylin, m.r., cotter, r. l., niemann, d., epstein, l., swartz, j. m., shepard, r. b., liu, x., nukuna, a., gendelman, 高爆彈 (1999). lymphotropic virions affect chemokine 捕手mediated neural apoptosis: implications for hiv-1-associated dementia. j. virol. 73 (10): 8256-8267. (pmid: 10482576)
9.zheng, j., thylin, m. r., ghorpade, a., xiong, h., persidsky, y., cotter, r., niemann, d., che, m., zeng, y., gelbard, h.a., shepard, r. b., swartz, j. m., gendelman, h. e. (1999). intracellular cxcr4 signaling, neuronal apoptosis, and the neuropathogenic mechanisms for hiv-1-associated dementia. j. neuroimmunol. 98:185-200, (pmid: 10430052)
10.zheng, j., zhang p., hexum, t.d. (1997). neuropeptide y inhibits chromaffin cell nicotinic receptor stimulated tyrosine hydroxylase activity through a receptor linked g-protein mediated process. 摩爾 pharmacol. 52: 1027-1033, (pmid: 9415712)
其他發表文獻
1.zheng, j., huang, y., tang, k., cui, m., niemann, d., lopez, a., morgello, s. and chen, s. (2008). hiv-1-infected and/or immune-activated macrophages regulate astrocyte cxcl8 production through il-1beta and tnf-alpha: involvement of mitogen-activated protein kinase and protein kinase r. journal of neuroimmunology (in press).
2.peng h, kolb r, kennedy j and zheng j. (2007). differential expression of cxcl12 and cxcr4 during human fetal neural progenitor cell differentiation. j. neuroimmunol pharm 2: 251-258. (pmid: 18040858)
3.zheng, j. and che, s-d. neuroimmune 藥理學 expanding in asia pacific rim. j. neuroimmunol pharm. 2(3):233-5. 2007
4.haorah, j., knipe, b., gorantla, s., zheng, j., and persidsky, y. (2007). 乙醇-induced blood-brain barrier dysfunction is mediated via 肌醇 1, 4, 5-triphosphate 捕手 (ip3r)-gated intracellular 一水合醋酸鈣 release. j. neurochem. 100:324-36. (pmid: 17241155).
5.erdmann, n. b., whitney, n. p., zheng, j. (2006). potentiation of excitotoxicity in hiv-1 associated dementia and the significance of glutaminase. clinical 神經科學 res. 6: 315-328. (pmid: 18059978)
6.peng, h., erdmann, n., whitney, n., dou, h., gorantla, s., gendelman, 高爆彈, ghorpade, a. and zheng, j. (2006). hiv-1-infected and/or immune activated macrophages regulate astrocyte sdf-1 production through il-1b. glia; 54:619-29. (pmid: 16944452)
7.yi, h., zhen, y., jiang, l., zheng, j. and zhao, y (2006). the phenotypic characterization of naturally occurring regulatory cd4+cd25+ t cells. cellular & molecular immunology 3: 189-195. (pmid: 16893499)
8.peng, h., huang, y., duan, z., erdmann, n., xu, d., herek, s., and zheng, j. (2005). cellular iap1 regulates trail-induced apoptosis in human fetal cortical neural progenitor cells. j. neurosci. res. 82: 295-305. (pmid: 16180223)
9.huang, y., erdmann, n., zhao, j. and zheng, j. (2005). the signaling and apoptotic effects of tnf-related apoptosis-inducing ligand in hiv-1 associated dementia. neurotoxicity research 8: 135-148. (pmid: 16260391)
10.huang, y., erdmann, n., peng, h., zhao, y. and zheng, j. (2005). the role of tnf-related apoptosis-inducing ligand in neurodegenerative diseases. cellular and molecular immunology 2:113-122. (pmid: 16191417)
11.kaul, m., zheng, j., okamoto, s., gendelman, he and lipton, sa (2005). hiv-1 infection and 艾滋病: consequences for the central nervous system. cell 死亡 and differentiation. 12 suppl 1:878-92. (pmid: 15832177)
12.deshpande, m., zheng, j., borgmann, k., persidsky, r., wu, l., schellpeper, c. and ghorpade, a. (2005). role of activated astrocytes in neuronal damage: potential links to hiv-1-associated dementia. neurotoxicity research 7 (3): 183-192. (pmid: 15897153)
13.peng, h., huang, y., rose, j., erichsen, d., herek, s., fujii, n., tamamura, h. and zheng, j. (2004). stromal cell-derived factor 1 mediated cxcr4 signaling in rat and human cortical neural progenitor cells. journal of 神經科學 research 76: 35-50. (pmid: 15048928)
14.ryan, l., peng, h., erichsen, d., persidsky, y., zhou, y., gendelman, 高爆彈 and zheng, j. (2004). links between tumor necrosis factor related apoptosis inducing ligand mediated human neuronal apoptosis and hiv-1 associated dementia. j. neuroimmunol. 148 (1-2): 127-139. (pmid: 14975593)
15.ryan, l., brester, m., bohac, d., morgello, s. and zheng, j. (2004). upregulation of soluble tnf 捕手 two in plasma of hiv seropositive individuals who use opiates. 艾滋病 research and human retroviruses. 20 (1): 41-45. (pmid: 15000697)
16.zhao, j., lopez, a. l., erichsen, d., herek, s., cotter, r. l., curthoys, n. p. and zheng, j. (2004). mitochondrial glutaminase enhances extracellular glutamate production in hiv-1 infected macrophages: linkage to hiv-1 associated dementia. journal of neurochemistry 88: 169-180. (pmid: 14675161)
17.ikezu, t., luo, x., weber, g. a., zhao, j., mccabe, l., buescher, j.l., ghorpade, a., zheng, j. and xiong, h. (2003). amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sapp and ab mediated neurotoxicity. j. neurochem. 85: 925-34. (pmid: 12716424)
18.erichsen, d., lopez, a.l., peng, h., niemann, d., williams, c., bauer, m., morgello, s., cotter, 自由歐洲電臺, ryan, l.a., ghorpade, a., gendelman, 高爆彈 and zheng, j. (2003). neuronal injury induced fractalkine production: relevance to hiv-1 associated dementia. j. neuroimmunol. 138: 144-155. (pmid: 12742664)
19.luo, x., weber, g., zheng, j., gendelman, 高爆彈 and ikezu, t. (2003). c1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of alzheimer's disease. j. neuroimmunol. 135: 62-71. (pmid: 12576225)
20.xiong, h., boyle, j., winkeibauer, m., gorantla, s., zheng, j., ghorpade, a., persidsky, y., carlson, k.a. and gendelman, 高爆彈 (2003). inhibition of long-term potentiation by interleukin-8: implication for hiv-1-associated dementia. j. neurosci. res. 71: 600-607. (pmid: 12548717)
21.zheng, j., zhou, g., hexum, t. d. (2000). neuropeptide y secretion from bovine chromaffin cells inhibits cyclic amp accumulation. life sci. 67: 617-625. (pmid: 12659167)
22.cotter, 自由歐洲電臺, williams, c., ryan, l., lopez, a., peng, h., and zheng, j. (2002). fractalkine and brain inflammation: implications for hiv-1-associated dementia. j. neurovirology. 8: 585-98. (pmid: 12476352)
23. ryan, l., cotter, 自由歐洲電臺, zink, w.e., gendelman, 高爆彈, zheng, j. (2002). macrophage, chemokines and neuronal injury in hiv-1 associated dementia. mol. cell. biol. 48 (2): 137-150. (pmid: 11995633)
24.ryan, l., zheng, j., brester, m., bohac, d., hahn, f., anderson, j., ratanasuwan, w., gendelman, 高爆彈, swindells, s. (2001). plasma soluble cd14 and tnf-a 捕手 two levels correlate with cognitive dys函數 during hiv-1 infection. j. infec. dis. 184(6): 699-706. (pmid: 11517430)
25.zheng, j., thylin, m.r., persidsky, y., williams, c. e., cotter, 自由歐洲電臺, zink, w., ryan, l., ghorpade, a., lewis, k., gendelman, 高爆彈 (2001). hiv-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise. neuro. res. 3(5): 461-484. (pmid: 14715459)
26.zheng, j., thylin, m.r., cotter, r. l., lopez, a. l., ghorpade, a., persidsky, y., xiong, h., leisman, g.b., che, m., gendelman, 高爆彈 (2001). hiv-1 infected and immune competent mononuclear phagocytes induce quantitative alterations in neuronal dendritic arbor: relevance for hiv-1-associated dementia. neuro. res. 3(5): 443-459. (pmid: 14715458)
27. jiang, z.-g., piggee, c., heyes, m.p., murphy, c., quearry, b., bauer, m., zheng, j., gendelman, 高爆彈, markey, s.p. (2001). glutamate is a mediator of neurotoxicity in secretions of activated hiv-1-infected macrophages. j neuroimmunol. 117: 97-107. (pmid: 11431009)
28. cotter, r., zheng, j.*, che, m., niemann, d., liu, y., he, j., thomas, e., gendelman, 高爆彈 (2001). regulation of hiv-1 infection, b-chemokines production and ccr5 expression in cd40l-stimulated macrophages: immune control of viral entry. j. virol. 75:4308-4320. (*corresponding author) (pmid: 11287580)
29.zhang, p., zheng, j., bradley, m. e., hexum, 旅行者腹瀉 (2001). atp stimulated cyclic amp formation in bovine chromaffin cells is enhanced by neuropeptide y. (evolution and pleiotropic function of npy and related peptides). peptides 22: 439-444. (pmid: 11287099)
30.persidsky, y., limoges, j., rasmussen, j., zheng, j., gearing, a., gendelman, h. e. (2001). reduction in glial immunity and neuropathology by a platelet activating factor antogonist and a matrix metalloproteinase and tnfa inhibitor in scid mice with hiv-1 腦炎 j. neuroimmunol. 114: 57-68. (pmid: 11240016)
31.yeh, m. w., kaul, m., zheng, j., nottet, B病毒l.m., thylin, m.r., gendelman, 高爆彈, lipton, 永恒沉睡 (2000). cytokine-stimulated but not hiv-infected human monocytes-derived macrophages produce neurotoxic levels of l-cysteine. j. immunol. 164: 4265-4270. (pmid: 10754324)
32.zhang, p., zheng, j., vorce, r. l., hexum, t. d. (2000). identification of an npy-y1 receptor subtype in bovine chromaffin cells. regul. pept. 87: 9-13. (pmid: 10710282)
33.wang, j., wang, l., zheng, j., anderson, j.l., toews, m.l. (2000). identification of distinct carboxyl-terminal domains mediating internalization and down-regulation of the 倉鼠 alpha-1b adrenergic receptors. 摩爾 pharmacol. 57: 687-694. (pmid: 10727513)
34.xiong, h., zeng, yong-chun, lewis, t., zheng, j., persidsky, y., gendelman, 高爆彈 (2000). hiv-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for hiv-1-associated dementia. j. neurovirol. 6 (suppl 1): s14-s23. (pmid: 10871761)
35.persidsky, y., zheng, j., miller, d., gendelman, 高爆彈 (2000). mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during hiv-1 associated dementia. j. leuk. biol. 68: 412-421. (pmid: 10985259)
36.cotter, r., burke, w., potter, j., zheng, j., gendelman, h. e. (1999). new insights into the neurodegenerative process of alzheimer’s disease: role of microglia-associated inflammation and neurotoxicity. j. leuk. biol. 65: 416-427.
37.zink, w. e., zheng, j., persidsky, y., poluektova, l., gendelman, 高爆彈 (1999). the neuropathogenesis of hiv-1 infection. fems immunol. med. micro. 22: 233-241.
38. zhang, p., zheng j., hexum, 旅行者腹瀉 (1999). bibp 3226 inhibition of nicotinic 捕手 mediated chromaffin cell secretion. euro. j. pharmacol. 362: 121-125. (pmid: 9874161)
39.xiong, h., zeng, y. c., zheng, j., thylin, m. gendelman, h.e. (1999). soluble hiv-1 infected macrophage secretory products mediate blockade of long-term potentiation: a mechanism for cognitive dysfunction in hiv-1-associated dementia. j. neurovirology 5: 519-528. (pmid: 10568889)
40.xiong, h., zheng, j., thylin, m.r., gendelman, 高爆彈 (1999). unraveling the mechanisms for neurotoxicity in hiv-1 associated dementia: inhibition of neuronal synaptic transmission by macrophage secretory products. 艾滋病 res. hum. retrov. 15: 57-63. (pmid: 10024053)
41.swindells, s., zheng, j., gendelman, 高爆彈 (1999). hiv-1 associated dementia: new insights into therapeutics and disease pathogenesis interventions. 艾滋病 patient care and stds 13(3): 153-163. (pmid: 10375263)
42.xin, s., zheng, j., bian, c., qin, w. (1999). effects of l-tetrahydropalmatine on decreasing blood 壓強 and improving coronary artery circulation. chinese j. of modern applied 藥學 16 (2): 8-10.
43.gendelman, 高爆彈, zheng, j., coulter, c.l., ghorpade, a., che, m., thylin, m.r., rubocki, r., persidsky, y., hahn, f., reinhard, j., swindells, s. (1998). suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency 病毒associated dementia. j. infec. dis. 178: 1000-1007, (pmid: 9806027)
44.zheng, j., gendelman, h.e. (1997). the hiv-1 associated dementia complex: a metabolic encephalopathy fueled by viral replication in mononuclear phagocytes. curr. opin. neurol. 10: 319-325, (pmid: 9266156)
45.wang, j., zheng, j., anderson, j.l., toews, m.l. (1997). a mutation in the hamster alpha-1b adrenergic 捕手 that differentiates two steps in the pathway of receptor internalization. 摩爾 pharmacol. 52: 306-313, (pmid: 9271354)
46. zheng, j., zhang, p., toews, m., hexum, 旅行者腹瀉 (1997). neuropeptide y enhance atpinduced formation of 肌醇 磷酸鹽 in chromaffin cells. biochem. biophys. res. comm 239: 287-290, (pmid: 9345312)
47.yao, b., ge, xq, zheng, j., qin, w., bian, c.f. (1996). effects of m1 and M2 捕手 agonists and blockers on dog respiration. acta pharmacologic sinica (zhongguo yao li xue bao) 17(3): 267-70, (pmid: 9812755)
48.zheng, j., morrisett, 類風濕性關節炎, zhu, j., hexum, 旅行者腹瀉 (1995). neuropeptide y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic 捕手 ion channel. j. pharmacol expt'l. ther. 274(2): 891-897, (pmid: 7543575)
49. ge, xq, zheng, j., qin, w., bian, c.f. (1995). inhibitory effect and mechanism of scopolamine on respiration. acta physiologica sinica 47(4): 397-402, (pmid: 7481883)
50.hexum, 旅行者腹瀉, zheng, j., zhu, j. (1994). modulation of chromaffin cell secretion by neuropeptide y. j pharmacol exp ther. 271: 61-66, (pmid: 7965758)
51.yao, b., zheng, j., qin, w., bian, c.f. (1994). inhibitory effect of 6 beta-acetoxy nortropane on respiration. yao-hsueh-hsueh-pao 29(7): 497-501, (pmid: 7976358)
52.zheng, j., bian, c.f., and yu, a.y. (1992). muscarinic 捕手 subtypes in respiratory center and their functions. acta pharmacologic sinica (zhongguo yao li xue bao) 13(4): 349-354, (pmid: 1456058)
53. mu, y., chen, y., chu, y., zheng, j., zhang, m. (1992). radioimmunoassay of gastric mucosal pges in portal hypertensive rats with cirrhosis. acata acad. med. xuzhou 12(4): 299-303.
54.zheng, j., bian, c.f. (1990). effect of 6b-an on respiration, eeg and heart rate in 兔形目 acta acad. med. xuzhou 11: 12-15.
55.zheng, j., bian, c.f. (1990). effect of af-dx 116 on respiration, eeg and heart rate in rat. acta acad. med. xuzhou 11: 39-42.
56.zheng, j., yu, a.y., bian, c.f. (1990). characterization of muscarinic receptor subtypes in the rat brain stem. acta acad. med. xuzhou 11: 5-10.
57.zheng, j., bian, c.f., ge, x.c. and yu, a.y. (1990). relationship between muscarinic receptor subtypes and the changes in eeg in rabbits. acta acad. med. xuzhou 10: 281-285.
58.bian, c.f., zheng, j., yi, x.x. and hong, x.m. (1990). effects of anticholinergic drugs on respiratory center. asia pacific j. pharmacal 5 (suppl): 12.參加編著的書籍 1.cotter, r., zheng, j., gendelman, h.e. (1998). the role of mononuclear phagocytes in neurodegenerative disorders: lessons from multiple sclerosis, alzheimer’s disease and hiv-1 associated dementia. in: advances in neurodegenerative disorders vol.2, alzheimer’s and aging, edited by j marwah and h teitelbaum, prominent press, scottsdale, AZ 203-241.
2.carlson, k. a., cotter, 自由歐洲電臺, williams, c.e., branecki, c.e., zheng, j., gendelman, 高爆彈 (2002). the role of mononuclear phagocytes in the pathogenesis of alzheimer’s disease. in: the macrophage 2nd ed., edited by b burke and c lewis, oxford medical publications, oxford.
3.anderson, e., ryan, l., xiong, h., swindells, s., zheng, j., and gendelman, h.e. (2004). neural immunity and human immunodeficiency 病毒1-associated dementia. page 547-559. in blood-spinal cord and brain barriers in health and disease, eds by h. s. sharma and j. westman, elsevier science, usa.
4.zheng, j., peng, h., rose, j. and herek, s. (2005). neurogenesis and its links to brain development, developmental therapeutics and the pathogenesis of neurodegenerative disorders including hiv-1 associated dementia. in the neurology of 艾滋病, second edition, eds by gendelman, 高爆彈, grant, i., lipton, s.a., everall, i., and swindells, s. page 239-253, oxford university press, oxford.
5.gendelman, h.e., anderson, e., melendez, l., and zheng, j. (2006) chemokines and their receptors and the neuropathogenesis of hiv-1 infection. in in vivo models of hiv disease and control. 電子數據系統 h. friedman, s. specter and m. bendinelli, springer, new york.
6.erdmann, n., huang, y. and zheng, j. (2007). the relevance of chemokines and cytokines to the pathogenesis of hiv-1 associated dementia. in the neuro-艾滋病, eds by paul shapshak and alireza minagar, nova science publisher, 特庫摩, hauppauge, ny. (in press)
7.peng, h., whitney, n.p., tang, k., toews, m. and zheng, j. (2008) stem cells and neurogenesis and its links to brain development and pathogenesis of neurodegenerative disorders. in the neuroimmue 藥理學 eds by tsney ikezu and howard e. gendelman, page 151-182, springer publisher, inc, ny.
8.huang, y., erdmann, n., hexum, t. and zheng, j. (2008). the relevance of chemokines, cytokines and growth factors to the pathogenesis of neurodegenerative disorders. in the neuroimmue 藥理學 eds by tsney ikezu and howard e. gendelman, page 183-205, springer publisher, inc, ny.
參與團體
美國神經科學協會，美國微生物協會，國際神經化學協會，國際神經病毒協會，美國免疫協會，國際神經毒性協會，國際神經免疫藥理學協會，國際神經免疫協會
研究項目
國家級與社會研究項目（美國）
1. HUAWEI P20 rr15635-01 (銅)
principle investigator & center director: wood, c
dates: 9/01/05 to 04/30/10 (year 6-10)
nih/ncrr（美國國立衛生研究院/ncrr）
“cxcr4, neurogenesis and hiv-1 associated dementia”
該項目主要研究cxcr4在hiv-1中的神經病理學作用。
project 2 leader: 鄭加麟2. 1 r01 ns 41858-01
principle investigator: 鄭加麟
dates: 06/01/05-04/30/10 (year 5-9)
nih/ninds（美國國立衛生研究院/ninds）
"trail and glutaminase: neurotoxic link in hiv dementia "
該項目的主要目的是研究hiv-1相關癡呆（had）trail與谷胺胺酶介導的神經損傷。表明病毒學、免疫學和受體藥理學在研究had機制中的相互關系.
3. 1 r01 ns 61642
principle investigator: 鄭加麟
dates: 07/01/08-06/30/13 (year 1-5)
nih/ninds（美國國立衛生研究院, /ninds）
"sdf-1 and neurogenesis in hiv-1 associated dementia"
4. po1ns 43985-01 (PPG)
principle investigator: gendelman, 高爆彈
dates: 05/15/03-04/30/13 (year 5-10)
nih/ninds（美國國立衛生研究院/ninds）
“neuronal chemokines and macrophage activation”
該項目的主要目的是研究神經趨化因子（fractalkine）在神經損傷中的反應。fractalkine介導的吞噬活動將被定義。一種特定的基因芯片技術將被用來判定hiv-1感染和fractalkine介導激活吞噬產物的表達和調節。
role: project 1 leader: 鄭加麟
5. 1r21mh083525-01
principle investigator: 鄭加麟
dates: 4/1/08-3/31/10
nih/nimh（美國國立衛生研究院/nimh）
“hiv-1 clade diversity and macrophage mediated neurotoxicity in hiv-1 dementia”
6. guilford pharmaceuticals r& d grant
principle investigator: 鄭加麟
dates: 8/15/04-9/14/08
guilford pharmaceuticals
title: “the effect of glutaminase inhibitors in hiv infection of macrophages”
7. 1ro1 ns41862-01
principle investigator: xiong, h.
dates: 06/01/05-03/30/10
nih/ninds（美國國立衛生研究院/ninds）
"macrophages, neuronal k+ channels and hiv-1 dementia”
該基金研究hiv-1感染的單核吞噬細胞影響神經突觸傳導及可塑性與nmda可塑性及nmda受體功能。
role: co-investigator: 鄭加麟
8. ro1 aa015913-01a
principle investigator: persidsky, y.
dates: 10/1/05-9/30/10
nih/ninds（美國國立衛生研究院/ninds）
“ppar-g mediated neuroprotection against hiv-1 and alcohol cns injury”
該基金用以研究ppar-g介導的抵抗hiv-1和乙醇引起的中樞神經損傷中的神經保護機制
role: co- investigator: 鄭加麟
已完成的研究項目
1. HUAWEI P20 rr15635-01 (銅)
principle investigator & center director: wood, c
dates: 10/01/00 to 08/30/05 (year 1-5)
nih/ncrr（美國國立衛生研究院/ncrr）
“cellular mechanisms for hiv-1 induced neuronal injury”
role: project 1 leader: 鄭加麟2. 1 r01 ns 41858-01
principle investigator: zheng, j.
dates: 06/01/01-05/31/05 (year 1-4)
nih/ninds（美國國立衛生研究院/ninds）
"macrophage activation, chemokines, and hiv dementia"
role: principle investigator: 鄭加麟
3. t32ns07488
principle investigator: gendelman, 高爆彈
dates: 7/1/02－6/30/07
nih/ncrr（美國國立衛生研究院/ncrr）
“training program in neurovirology”
role: co-principle investigator: 鄭加麟
研究成果
2022年8月3日消息，同濟大學附屬同濟醫院鄭加麟教授、夏驍寰研究員和同濟大學附屬上海市肺科醫院袁平副研究員團隊合作，使用簡易精神狀態檢查(MMSE)和蒙特利爾認知評估(MoCA)問卷分析了同濟大學附屬上海市肺科醫院肺循環科收治315例肺動脈高壓患者和315例對照者的認知障礙表現，并研究了認知功能功能障礙與肺動脈高壓發病風險、嚴重程度和臨床惡化事件之間的關系。結果提示肺動脈高壓患者存在認知障礙，該障礙與疾病的嚴重程度顯著相關，MMSE和MoCA總評分可獨立預測發病風險和預后表現。該研究工作首次發現了肺動脈高壓疾病進展與神經認知功能變化間的關系，提出了肺腦軸復雜雙向互作的重要理念，為肺動脈高壓疾病診斷與治療提供了新的靶標，并提示肺動脈高壓患者認知功能異常早期診斷與干預的重要性。該研究成果于7月29日在線發表于國際權威刊物American Journal of Respiratory and Critical Care Medicine（論文的通訊作者為同濟大學附屬同濟醫院鄭加麟教授、夏驍寰研究員，第一作者為同濟大學附屬上海市肺科醫院袁平副研究員等）。
參考資料 >
38人！基金委醫學科學部公布一項目評審專家名單.今日頭條.2023-06-19
同濟大學附屬同濟醫院鄭加麟、夏驍寰團隊發現肺動脈高壓影響認知功能.今日頭條.2022-08-03