鄒志華，男，現在在美國加爾韋斯頓的得克薩斯大學醫學分部工作。鄒志華到巴克在哈佛大學醫學院的實驗室做博士后。2002年他又跟隨巴克，前往弗雷德哈欽森癌癥研究中心繼續從事研究工作。
人物經歷
教育經歷
工作經歷
到巴克在哈佛大學醫學院的實驗室做博士后。
2002年又跟隨巴克，前往弗雷德·哈欽森癌癥研究中心繼續從事研究工作。
人物事件
諾貝爾獎得主琳達·巴克及其合作者在2008年3月6日出版的英國《自然》雜志發表聲明，宣布撤銷六年前在該雜志上刊登的一篇論文。而來自中國的鄒志華，則是該論文的共同第一作者。
主要成就
科研成就
論文
Zhihua?Zou,?Ph.D.Education??Bachelor?of?Medicine,?First?Military?Medical?University,?China,?1980-1985??碩士?of?Science,?First?Military?Medical?University,?China,?1985-1986??Doctor?of?哲學,?Osaka?University,?Japan,?1992-1997??Post-Doctoral?Training,?Harvard?Medical?School,?1997-2001?????????????????Fred?Hutchinson?Cancer?Research?內角,?2002-2005Research InterestsWe?use?molecular?genetic?approaches?to?study?neuronal?organizational?patterns?in?the?central?nervous?system.?The?human?brain?contains?more?than?100?billion?neurons?and?100?trillion?neuronal?connections.?Mental?activities?emerge?from?the?biological?properties?of?the?nerve?cells?and?of?their?patterns?of?Interconnection.?Neurons?with?similar?basic?properties?can?play?quite?different?roles?because?of?the?way?they?are?connected?with?each?other.?A?major?focus?of?our?lab?is?to?use?genetic?neuronal?markers?and?transneuronal?tracers?to?investigate?connectivity?between?brain?neurons.?Molecular?genetic?switches?are?then?used?to?temporarily?control?the?activity?of?identified?neural?circuits?in?order?to?understand?their?physiological?functions.?By?these?studies,?we?aim?to?understand?how?brain?neurons?are?assembled?into?functional?circuits,?the?relationship?between?different?patterns?of?interconnection?to?different?types?of?behavior,?and?how?neurons?and?their?connections?change?with?experience.Identification?of?泛函?neural?circuitsTo?understand?the?neural?bases?of?behaviors,?we?developed?a?bi-cistronic?construct?that?expresses?a?transneuronal?示蹤劑?(barley?lectin,?BL)?and?a?neuronal?馬克筆?(GFP-tetanus?毒素?fragment?C?fusion?protein,?GFP-TTC).?When?expressed?in?neurons,?GFP-TTC?fills?the?entire?neuronal?compartment,?including?dendrites?and?axons,?and?BL?serves?as?a?retro-?as?well?as?anterograde?transneuronal?示蹤劑,?allowing?us?to?visualize?the?projections?as?well?as?the?SynapticTargets?of?specific?groups?of?brain?neurons.?We?use?gene?targeting?and?viral?vectors?to?deliver?these?genetic?molecular?markers?to?subsets?of?neurons?with?distinct?molecular?identity.?Moreover,?we?also?generated?a?gene?targeted?mouse?line?whereby?the?expression?of?a?short-lived?GFP?is?dependent?on?neural?activity,?hence?labeling?behaviorally?relevant?neural?circuits.?Another?construct?expresses?an?ivermectin?(IVM)-gated?氯代十六烷?channel?from?C.?elegans?(IVM-GluCl).?systematically?administrating?IVM?reversibly?suppresses?excitability?of?neurons?expressing?IVM-GluCl,?thus?allowing?us?to?investigate?physiological?functions?of?a?particular?neural?circuit.Odor?and?信息素?sensingAnimals,?including?家蠅,?cockroaches,?mosquitoes,?and?wild?鼠科,?rely?heavily?on?odors?and?Pheromones?for?individual?survival?and?物種?extension.?Understanding?the?unique?odor?and?信息素?components?that?are?relevant?to?specific?biological?activities?will?not?only?allow?for?analysis?of?the?neural?circuits?underlying?olfactory?behaviors?but?also?provide?AVENUES?to?監察?the?種群?開本?of?pests.?We?are?studying?the?sensory?neurons?and?receptors?that?are?activated?by?specific?olfactory?behaviors,?which?will?aid?in?the?identification?of?the?odor?and?信息素?components.?Meanwhile,?we?are?also?investigating?how?odor?information?is?organized?and?processed?in?the?brain?to?bring?about?specific?odor?perceptions?and?odor-evoked?behavioral?responses.We?have?developed?a?gene-targeted?mouse?line?to?label?odor-?or?behaviorally-activated?olfactory?sensory?neurons?and?bulb?glomeruli?by?GFP,?which?will?allow?us?to?identify?the?relevant?odorant?receptors.?Identification?of?behaviorally-activated?receptors?is?a?necessary?step?for?studies?to?screen?different?odor?fractions?and?individual?odor?components?to?reveal?the?identity?of?biologically?significant?olfactory?stimuli,?to?dissect?the?roles?of?different?olfactory?sub-systems?in?regulating?specific?olfactory?behaviors,?and?to?characterize?how?signals?from?these?receptors?are?routed?in?the?brain?to?regulate?distinct?behaviors.A?Fundamental?principle?of?sensory?information?coding?is?that?sensory?stimuli?are?first?deconstructed?into?unitary?neural?signals?in?the?periphery;?progressive?convergence?of?afferent?inputs?then?generates?cells?with?increasingly?complex?response?properties.?Each?cell?at?a?higher?level?surveys?the?activity?of?a?基團?of?cells?at?a?lower?level.?The?olfactory?system?resembles?other?sensory?systems?in?that?each?odorant?receptor?recognizes?a?specific?structural?feature?in?individual?odor?molecules?and?thus?each?odorant?or?odor?mix?is?encoded?by?multiple?different?odorant?receptors.?As?olfactory?sensory?neurons?expressing?the?same?type?of?receptor?project?axons?to?the?same?glomeruli?in?the?olfactory?bulb,?each?bulb?glomerulus?represents?a?single?type?of?receptor?and?each?odor?is?encoded?by?activity?in?a?specific?組合?of?glomeruli,?inputs?of?which?may?be?integrated?in?cortical?neurons?to?reconstruct?an?odor?image?in?the?brain.?We?are?systematically?investigating?how?the?olfactory?bulb?is?mapped?onto?the?various?regions?of?the?olfactory?cortex.?Meanwhile,?we?are?also?interested?in?the?泛函?implications?of?neurogenesis?in?the?adult?olfactory?bulb?and?how?odor?information?affects?behaviors?-?such?as?fear,?aggression?and?appetite.Neural?and?Metabolic?監察?of?Food?Intake?and?MetabolismAppetite?and?新陳代謝?is?tightly?controlled?by?molecularly?distinct?subsets?of?neurons?in?the?hypothalamus,?which?integrate?neural?(sensory,?hedonic?and?cognitive)?as?well?as?hormonal?signals?to?coordinate?food?intake?and?能量?expenditure.?We?use?viral?vectors?to?express?genetic?markers?and?drug-controllable?neuronal?channels?in?specific?groups?of?these?neurons.?These?studies?aim?to?map?the?neural?circuits?that?stimulate?or?inhibit?food?intake?and?新陳代謝,?and?to?reveal?novel?targets?for?treatment?of?肥胖癥?and?eating?disorders.?In?addition,?peripheral?tissues?secret?a?variety?of?hormones?that?stimulate?or?suppress?appetite.?The?levels?of?these?hormones?fluctuate?according?to?能量?availability.?We?are?studying?the?molecular?mechanisms?by?which?peripheral?tissues?sense?energy?levels?to?監察?the?secretion?of?these?hormones.
Recent PublicationsZou,?Z.?and?Buck,?L.?Combinatorial?Effects?of?Odorant?Mixes?in?Olfactory?Cortex.?Science?311,?1477-1481,?2006Boehm,?U.,?Zou,?Z.,?and?Buck,?L.?Feedback?loops?link?odor?and?信息素?信令?with?復制?細胞?123(4):?683-695,?Nov.?18,?2005Zou,?Z.,?Li,?F.,?Buck,?L.?Odor?maps?in?the?olfactory?cortex.?Proc?Natl?Acad?Sci?USA?102?(21),?7724-7729,?2005
參考資料 >
鄒志華.吉林大學生命科學學院.2024-04-27