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白凡，北京大學生物醫學前沿創新中心研究員。

第六屆中源協和生命醫學獎獲獎者名單揭曉，白凡獲得創新科學突破獎。

人物經歷

教育經歷

2010.04-2010.05　　Visiting Scholar, Virginia Polytechnic Institute and State University

2004.09-2004.12　　Visiting Scholar, The University of 加利福尼亞州 at Berkeley

2003.09-2008.09　　Doctor of 哲學 major in Biological Physics, University of Oxford

1999.09-2003.06　　Bachelor of Science, Peking University, Department of Physics

工作經歷

2014.09-present　　Assistant The Professor, PI

2011.08-2014.08　　Assistant Professor, Co-PI with Professor Sunney Xiaoliang Xie.

2009.09-2011.08　　JSPS Postdoctoral research fellow, Osaka University

2008.09-2009.09　　IRC and EPSRC Postdoctoral research fellow, University of Oxford

社會任職

2017-2020，中國醫療保健國際交流促進會臨床微生物與感染分會委員。

2018-2022，中國醫藥生物技術協會基因檢測技術分會委員會常委，副秘書長。

2018-2023，北京亞太肝病診療技術聯盟肝膽腫瘤專業委員會副主任委員。

主要成就

科研領域

白凡實驗室致力于將先進的單細胞、單分子研究方法，應用于重大醫學疾病問題的研究。

實驗室研究方向：　　

研究方向一：單細胞基因測序技術應用于癌癥病人外周血循環腫瘤細胞研究，深入探索癌癥轉移的分子生物學機制及通過循環腫瘤細胞測序進行無創癌癥診斷、預后判斷、療效評價的臨床方法。　　

研究方向二：大樣本基因測序研究癌癥發生、轉移機制。針對明確的臨床問題，采用基因測序手段研究中國人群高發癌癥的突變特征，發掘引起癌癥表型轉化、轉移的關鍵驅動事件。　　

研究方向三：綜合使用基因測序、熒光成像手段研究細菌行為、致病性，抗生素殺菌原理和細菌抗藥、耐藥的分子機制。

代表性論文

單細胞測序腫瘤基因組學方向

Single-細胞 Sequencing and Cancer Genomics

1. Wang J#, Xu Y#, Chen Z#, Liang J#, Lin Z#, Liang H#, ……, Bai F*, Xia H*, Wen Z*, Zhang Y*, Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia, 細胞 183 (2020), pp. 1867-1883

2. Li R#, Du Y#, Chen Z#, Xu D#, Lin T#, Jin S, Wang G, Liu Z, Lu M, Chen X, Xu T*, Bai F*, Macroscopic somatic clonal expansion in morphologically normal human urothelium, Science 370 (2020), pp. 82-89

3. Jin S#, Li R#, Chen M#, Yu C#, Tang L#, …….., Mai H, Gewurz B, Zhao B, Young L, Zhong Q*, Bai F*, Zeng M*, Single-cell transcriptomic analysis defines the Interplay娛樂 between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma, 細胞 Research 30 (2020), pp. 950-965

4. Zhang J#, Wang X#, Xing X#, Xu Z#, ……., Zhang Y, Zumla A, Maeurer M, Bai F*, Wang F*, Single-cell landscape of immunological responses in patients with COVID-19, Nature Immunology 21 (2020), pp. 1107-1118

5. Zhang C#, Zhang L#, Xu T#, Xue R#, Yu L#, Zhu Y, Wu Y, Zhang Q, Li D, Shen S, Tan D, Bai F*, Zhang H*, Mapping the spreading routes of lymphatic metastases in human colorectal cancer, Nature Communications 11 (2020), 1993

6. Wang X#, Lu Y#, Song Y#, Dong J#, Li R, Wang G, Wang X, Zhang S, Dong Z, Lu M, Wang S, Ge L, Luo G, Ma R, Rozen S, Bai F*, Wu D*, Ma L*, Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus, Nature Communications 11 (2020), 739

7. Huang B#, Chen Z#, Geng L#, Wang J#, Liang H#, ......, Gong S*, Bai F*, Yang M*, Zhang Y*, Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways, Cell 179 (2019), pp. 1160-1176

8. Fujimaki K#, Li R#, Chen H, Della Croce K, Zhang H, Xing J, Bai F*, Yao G*, Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch, Proceedings of the National Academy of Sciences USA 116 (2019), pp. 22624-22634

9. Su Z#, Wang Z#, Ni X#, Duan J#, Gao Y#, Zhuo M, Li R, Zhao J, Ma Q, Bai H, Chen H, Wang S, Chen X, An T, Wang Y, Tian Y, Yu J, Wang D, Xie X*, Bai F*, Wang J*, Inferring evolution and progression of small-cell lung cancer by single-cell sequencing of circulating tumor cells, Clinical Cancer Research 25 (2019), pp. 5049-5060

10. Xue R#, Chen L#, Zhang C#, Fujita M#, ……, Nakagawa H*, Zeng M*, Bai F*, Zhang N*, Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic 膽管癌 reveals distinct molecular subtypes, Cancer Cell 35 (2019), pp. 932-947

11. Jiang Y#, Ma D#, Suo C#, Shi J#, Xue M#, Liu Y, Xiao Y, Hu X, Yu Y, Zhang J, Li B, Li X, Zheng Y, Ren L, Hou W, Zhao S, Gong Y, Ren Y, Zhang C, Niu Z, Bai F, Yu K, Wang P*, Shi L*, Huang W*, Shao Z*, The genomic and transcriptomic landscape of triple-negative breast cancer suggests subtype-specific treatment strategies in Chinese 種群, Cancer Cell 35 (2019), pp.428-440.e5

12. Liu M#, Liu Y#, Deng L#, Wang D, He X, Zhou L, Wicha M, Bai F*, Liu S*, Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer, Molecular Cancer 17(2018), pp. 65

13. Chen X#, Yan S#, Liu Y#, Zhong Q#, Chen Z#, Jin S#, Xia T, Li R, Zhou A, Su Z, Huang Y, Huang Q, Huang L, Zhang X, Zhao Y, Yun J, Wu Q, Lin D, Bai F*, Zeng M*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole exome sequencing, Nature Communications 8 (2017), pp. 524

14. Gao Y#, Ni X#, Guo H#, Su Z#, Ba Y#, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F*, Xie S*, Zhang N*, Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells, Genome Research 27 (2017), pp. 1312-1322

15. Du Y#, Li R#, Chen Z#, Wang X, Xu T*, Bai F*, Mutagenic factors and complex clonal relationship of multifocal urothelial cell carcinoma, European Urology 71 (2017), pp. 841–843

16. Xue R#, Li R#, Guo H#, Guo L#, Su Z, Ni X, Qi L, Zhang T, Li Q, Zhang Z, Xie XS, Bai F*, Zhang N*, Variable extent of intra-tumor heterogeneity revealed by genomic sequencing of multiple lesions in patients with hepatocellular carcinoma, Gastroenterology 150 (2016), pp. 998-1008

17. Ni X#, Zhuo M#, Su Z#, Duan J#, Gao Y#, Wang Z#, Zong C#, Bai H, Chapman A, Zhao J, Xu L, An T, Ma Q, Wang Y, Wu M, Sun Y, Wang S, Li Z, Yang X, Yong J, Su X, Lu Y, Bai F*, Xie X*, Wang J*, Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients, Proceedings of the National Academy of Sciences USA 110 (2013), pp. 21083-21088

18. Lu S#, Zong C#, Fan W#, Yang M#, Li J, Chapman A, Zhu P, Hu X, Xu L, Yan L, Bai F, Qiao J, Tang F, Li R*, Xie X*, Probing meiotic recombination and aneuploidy of single sperm cells by whole genome sequencing, Science 338 (2012), pp. 1627-1630

細菌生理及抗生素耐藥

Bacterial Physiology and Antibiotic Tolerance

1. Zhuang X#, Guo S#, Li Z#, Zhao Z#, Kojima S, Homma M, Wang P, Lo C*, Bai F*, Live-cell 熒光 imaging reveals dynamic production and loss of bacterial flagella, Molecular Microbiology (2020), (April 07, 2020 online)

2. Wang Y#, Tian T#, Zhang J#, Jin X#, Yue H, Zhang X, Du L, Bai F*, Indole reverses the intrinsic antibiotic resistance of Lysobacter by promoting the expression of a novel dual-函數 importer, mBio 10 (2019), e00676-19

3. Pu Y#, Li Y#, Jin X#, Tian T#, Ma Q, Zhao Z, Lin S, Chen Z, Li B, Leake MC, Lo CJ, Bai F*, 巴西網球公開賽dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance, Molecular Cell 73 (2019), pp. 1-14 (November 21, 2018 online)

4. Zhao Z#, Zhao Y#, Zhuang X#, Lo W, Baker MA, Lo C*, Bai F*, Frequent pauses in Escherichia coli flagella elongation revealed by single cell real-時間熒光 imaging, Nature Communications 9 (2018), pp. 1885

5. Chen M#, Zhao Z#, Yang J#, Peng K, Baker M, Bai F*, Lo C*, Length-dependent flagellar growth of Vibrio alginolyticus revealed by real time fluorescent imaging, eLife (2017), DOI: http://dx.doi.org/10.7554/eLife.22140

6. Pu Y, Ke Y*, Bai F*, Active efflux in dormant bacterial cells – new insights into antibiotic persistence, Drug Resistance Updates 30 (2017), pp. 7-14 (invited review)

7. Buda R#, Liu Y#, Yang J#, Hegde S#, Stevenson K, Bai F*, Pilizota T*, 動力學 of 埃希氏菌屬 coli’s passive response to a sudden decrease in external osmolarity, Proceedings of the National Academy of Sciences USA 113 (2016), pp. E5838-E5846

8. Pu Y#, Zhao Z#, Li Y#, Zou J, Ma Q, Zhao Y, Ke Y, Zhu Y, Chen H, Baker A.B. M, Ge H, Sun Y, Xie XS*, Bai F*, Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells, Molecular Cell 62 (2016), pp. 284-294

9. Ma Q, Sowa Y, Baker M*, Bai F*, Conformational spread in the flagellar motor switch in response to CheY-P regulation and motor structural alterations, Biophysical Journal 110 (2016), pp. 1411-1420

10. Xue R#, Ma Q#, Baker M, Bai F*, A delicate nanoscale motor made by nature-the bacterial flagellar motor, Advanced Science 2 (2015), pp. 1500129 (invited review)

11. Bai F*, Che YS, Kami-ike N, Ma Q, Minamino T, Sowa Y, Namba K*, Populational heterogeneity vs. temporal fluctuation in Escherichia coli flagellar motor switching, Biophysical Journal 105 (2013), pp. 2123-2129

12. Bai F, Minamino T, Wu Z, Namba K*, Xing J*, Coupling between switching regulation and torque generation in bacterial flagellar motor, Physical Review Letters 108 (2012), pp. 178105

13. Ma Q, Nicolau D, Berry R, Maini P. Bai F*, Conformational spread in the flagellar motor switch: a model study, PLoS Computational Biology 8 (2012), pp. e1002523

14. Bai F#, Branch R#, Nicolau D#, Pilizota T, Steel, B, Maini P, Berry R*, Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch, Science 327 (2010), pp. 685-689

15. Bai F, Lo C, Berry R, Xing J*, Model studies on the 動力學 of bacterial flagellar motor, Biophysical Journal 96 (2009), pp. 3154-3167

16. Leake MC, Chandler JH, Wadhams GH, Bai F, Berry RM, Armitage JP*, Stoichiometry and turnover in single, functioning membrane protein complexes, Nature 443 (2006), pp. 355-358　

17. Xing J, Bai F, Berry R, Oster G*, Torque-speed relationship of the bacterial flagellar motor, Proceedings of the National Academy of Sciences USA 103 (2006), pp. 1260-1265