陳寶安是東南大學(xué)醫(yī)學(xué)院教授，專業(yè)領(lǐng)域?yàn)檠翰∨c腫瘤學(xué)。他是全國(guó)知名的專家，備受尊重和信任。
人物經(jīng)歷
教育經(jīng)歷
1979年畢業(yè)于南京鐵道醫(yī)學(xué)院醫(yī)療系（今東南大學(xué)醫(yī)學(xué)院），美國(guó)MD Aderson Cancer Center、加利福尼亞大學(xué)伯克利分校、德國(guó)海德堡大學(xué)等多所世界著名大學(xué)高級(jí)訪問學(xué)者。
畢業(yè)后先后在南京鐵道醫(yī)學(xué)院完成碩士，復(fù)旦大學(xué)上海醫(yī)學(xué)院（今復(fù)旦大學(xué)上海醫(yī)學(xué)院）完成博士學(xué)位，在烏爾姆大學(xué)血液腫瘤科完成博士后研究工作。
工作經(jīng)歷
現(xiàn)任東南大學(xué)附屬中大醫(yī)院血液科學(xué)科帶頭人、骨髓增生異常綜合征研究所所長(zhǎng)、腫瘤學(xué)系主任。兼任中國(guó)抗癌協(xié)會(huì)臨床腫瘤學(xué)協(xié)作專業(yè)委員會(huì)執(zhí)行委員、江蘇省抗癌協(xié)會(huì)理事、中華醫(yī)學(xué)會(huì)江蘇省血液學(xué)會(huì)副主任委員、中華醫(yī)學(xué)會(huì)南京血液學(xué)會(huì)前主任委員。
主要成就
科研成就
研究方向
腫瘤耐藥方面的研究
白血病治療失敗的主要原因之一為多藥耐藥，在國(guó)家自然科學(xué)基金資助下，研究發(fā)現(xiàn)漢防己甲素是一種非選擇性鈣離子通道阻滯劑，它能提高化療藥物對(duì)白血病細(xì)胞的抑制率，且對(duì)正常的骨髓細(xì)胞無抑制作用。心肌毒副作用低，實(shí)驗(yàn)用量臨床可以接受；他莫西芬可通過改善膜結(jié)構(gòu)，竟?fàn)幮砸种颇ぬ堑鞍讓?duì)化療藥物的轉(zhuǎn)運(yùn)。二者單獨(dú)應(yīng)用均能逆轉(zhuǎn)多藥耐藥。經(jīng)專家評(píng)定，此方面研究已達(dá)到國(guó)際先進(jìn)水平。
基因技術(shù)的研究
已完成了檢測(cè)腫瘤微轉(zhuǎn)移的基因芯片的研究，并獲得了國(guó)家知識(shí)產(chǎn)權(quán)及發(fā)明專利；并進(jìn)行了蛋白質(zhì)芯片的研究，《應(yīng)用蛋白質(zhì)芯片檢測(cè)多藥耐藥蛋白表達(dá)水平》于中華腫瘤雜志2005年發(fā)表。目前由江蘇省衛(wèi)生廳資助的重點(diǎn)項(xiàng)目“微轉(zhuǎn)移基因芯片研制及在消化道惡性腫瘤中的應(yīng)用研究”正在進(jìn)行中。
阻斷腫瘤新生血管的物理原理及生物效應(yīng)
針對(duì)腫瘤血管生成的治療措施可成為一個(gè)新穎抗癌途徑。目前此方面的研究主要集中在對(duì)腫瘤血管生成因子，和抗內(nèi)皮細(xì)胞增殖和遷移的方面。通過前期研究，發(fā)現(xiàn)通過超聲空化及空化核的增強(qiáng)效應(yīng)，直接損傷腫瘤新生血管，并已完成了低功率超聲輻射二氧化碳微泡劑致使腫瘤血管拴塞的實(shí)驗(yàn)研究，。將進(jìn)一步對(duì)動(dòng)物移植瘤做進(jìn)一步的研究，并準(zhǔn)備進(jìn)行臨床研究，以期建立無創(chuàng)誘導(dǎo)致腫瘤新生血管內(nèi)皮細(xì)胞損傷及阻斷腫瘤血液供應(yīng)的新方法。
造血干細(xì)胞移植
近幾年開展了非清髓造血干細(xì)胞移植36例，療效滿意，治療相關(guān)毒副反應(yīng)小，經(jīng)濟(jì)費(fèi)用較低，使白血病患者擺脫了病痛，目前處于國(guó)內(nèi)領(lǐng)先水平，在全國(guó)范圍內(nèi)產(chǎn)生了深遠(yuǎn)影響。
課題項(xiàng)目
1. 國(guó)家自然科學(xué)基金面上項(xiàng)目：漢防已甲素和角羅西芬逆轉(zhuǎn)白血病細(xì)胞多藥耐藥的機(jī)理研究（編號(hào)：39970832，研究年限：2000.11－2002.12）已結(jié)題
2. 南京市重大課題：非清髓造血干細(xì)胞移植治療白血病（編號(hào)：YQ0008，研究年限：2001－2004）已結(jié)題
3. 江蘇省衛(wèi)生廳科技發(fā)展基金：生物療法在慢性白血病ASCT體外凈化作用（編號(hào)：H200344，研究年限：2003－2005）已結(jié)題
4. 東南大學(xué)東南大學(xué)附屬中大醫(yī)院重大課題：非清髓造血干細(xì)胞移植治療血液病（編號(hào)：2003YJ02，研究年限：2003－2005）已結(jié)題
5. 高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金：共聚合漢防己甲素和化療藥物的磁性納米四氧化三鐵顆粒在逆轉(zhuǎn)惡性血液病多藥耐藥中的機(jī)理研究（編號(hào)：20070286042，研究年限：2008－2010）已結(jié)題
6. 國(guó)家自然基金面上項(xiàng)目：共聚合漢防己甲素和化療藥物的磁性納米四氧化三鐵顆粒在逆轉(zhuǎn)惡性血液病多藥耐藥中的機(jī)理研究（編號(hào)：30740062，研究年限：2008－2009）已結(jié)題7. 國(guó)家自然基金面上項(xiàng)目：磁性納米四氧化三鐵顆粒共聚合柔紅霉素和5－溴漢防己甲素逆轉(zhuǎn)惡性血液病多藥耐藥的機(jī)理研究（編號(hào)：30872970，研究年限：2009－2011）已結(jié)題8. 國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863計(jì)劃）子課題：急性白血病的治療（研究年限：2009－2011）已結(jié)題
9. 國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863計(jì)劃）子課題：超靈敏納米多孔生物傳感器件的研究與開發(fā)（編號(hào)：32007AA022007，研究年限：2009－2011）已結(jié)題
10. 國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）子課題：基于仿生分子識(shí)別的傳感與成像方法研究及其系統(tǒng)設(shè)計(jì)（編號(hào)：2010CB732404，研究年限：2009-2015）在研
11. 國(guó)家科技支撐計(jì)劃課題（十一五）子課題：骨髓增生異常綜合征的規(guī)范化診斷與治療策略研究（編號(hào)：2008BAI61B02，研究年限：2008－2010）已結(jié)題
12. 國(guó)家自然基金面上項(xiàng)目：化療藥和中藥與轉(zhuǎn)鐵蛋白納米載體的設(shè)計(jì)及逆轉(zhuǎn)白血病耐藥的機(jī)制研究（編號(hào)：81170492，研究年限：2012－2015）在研
13. 國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863計(jì)劃）子課題：針對(duì)生物標(biāo)志物檢測(cè)的低成本檢測(cè)系統(tǒng)的研制（編號(hào)：2012AA022703，研究年限：2012－2016）在研
14. 國(guó)家自然基金面上項(xiàng)目：血小板靶向載藥系統(tǒng)的研制及其抗白血病效應(yīng)的研究（編號(hào)：81370673，研究年限：2014－2017）在研
15. 江蘇省科技廳醫(yī)學(xué)重點(diǎn)項(xiàng)目：江蘇省復(fù)發(fā)和難治性白血病的規(guī)范化治療（編號(hào)：BL2014078，研究年限：2014－2017）在研
發(fā)表論文
1.CaiX, Cai X, Wang C,Chen BA*, Hua W, Shen Fet al. Antitumor efficacy of DMSA modified 四氧化三鐵 magneticnanoparticles combined with 砷 trioxide and adriamycin in Raji cells.J Biomed Nanotech2014;10(2):251-261.
2.ChangH, Wang X, Shiu KK, Zhu Y, Wang J, Li Q,Chen BA*et al. Layer-by-layer assembly of graphene, Au andpoly(toluidine 藍(lán)色 O) films sensor for evaluation of oxidative stress of tumorcells elicited by 氫 過氧化物Biosensors& Bioelectronics2013;41:789-794.
3.ChengJ, Cheng L,Chen BA*, Xia G, Gao C, Song Het al. Effect of magnetic nanoparticles of 四氧化三鐵 and wogonin onthe reversal of multidrug resistance in K562/A02 細(xì)胞 譜線 Int J Nanomedicine2012;7:2843-2852.
4.FangL,Chen BA,Liu S, Wang R, Hu S, Xia G,Chen BA*et al.Synergistic effect of a 組合 of nanoparticulate 四氧化三鐵 and gambogic acidon phosphatidyl肌醇 3-kinase/Akt/Bad pathway of LOVO cells. Int JNanomedicine2012;7:4109-4118.
5.JiangN, Zhu X, Zhang H, Wang X, Zhou X, Gu J,Chen BA*et al. The relationship between methylenetetrahydrofolatereductase polymorphism and hematological malignancy.Clin Lab2014;60(5):767-774.
6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A,Chen BAet al. Suppression of 巨細(xì)胞病毒specific CD8(+)T cells by everolimus.Leuk Lymphoma2014;55(5):1144-1150.
7.LiK,Chen BA*,Xu L, Feng J, Xia G, Cheng Jet al.Reversal of multidrug resistance by cisplatin-loaded magnetic 四氧化三鐵nanoparticles in A549/DDP lung cancer cells in vitro and in vivo Int J Nanomedicine 2013;8:1867-1877.
8.LiangG, Li J, Sun B, Li S, Lu L, Wang Y,Chen BA*et al. Deep sequencing reveals complex mechanisms ofmicroRNA deregulation in colorectal cancer.IntJ 腫瘤學(xué)2014;45(2):603-610.
9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L,Chen BA*et al. Role of NKG2D in 細(xì)胞因子induced killer cellsagainst multiple myeloma cells.CancerBio Therapy2012;13(8):623-629.
10.MouY, Hou Y,Chen BA*, Hua Z, Zhang Y, Xie Het al. In vivo migration of dendritic cells labeled with syntheticsuperparamagnetic iron 氧化物 Int J Nanomedicine 2011;6:2633-2640.
11.RenY, Zhang H,Chen BA*, Cheng J, Cai X, Liu Ret al. Multifunctional magnetic 四氧化三鐵 nanoparticles combined withchemotherapy and hyperthermia to overcome multidrug resistance. Int J Nanomedicine2012;7:2261-2269.
12.SongG, Gu L, Li J, Tang Z, Liu H,Chen BA*et al. Serum microRNAexpression profiling predict response to R-CHOP treatment in diffuse large Bcell lymphoma patients.Ann Hematol2014.e-pub ahead of print 2014/05/27
13.WangC, Cai X,Chen BA*, He Z, Chen Z, Cen Jet al. Up-regulation of tissue inhibitor of metalloproteinase-2promotes SHI-1 cell invasion in nude 鼠科Leuk 淋巴瘤2013;54(12):2707-2711.
14.WangC, Zhang H, Chen Y, Shi F,Chen BA*. Gambogic acid-loaded magnetic Fe(3)O(4)nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migrationby inactivating transcription factor ETS1. Int J Nanomedicine2012;7:781-787.
15.Wang F, Zhang W, Guo L, Bao W,Jin N, Liu R,Chen BA*et al. Gambogic acid suppresses hypoxia-inducedhypoxia-inducible factor-1alpha /vascular endothelial growth factor expressionvia inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein ofrapamycin pathway in multiple myeloma cells.Cancer Sci2014. e-pub ahead of print 2014/06/04.
16.WangL, Zhang H,Chen BA*, Xia G, Wang S, Cheng Jet al. Effect of magnetic nanoparticleson apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine2012;7:789-798.
17.WangX, Wang X, Gao S, Zheng Y, Tang M,ChenBA*. A 固體state electrochemiluminescencesensing platform for detection of catechol based on novel luminescent compositenanofibers.Talanta2013;107:127-132.
18.WenJ, Jiang S, Chen Z, Zhao W, Yi Y, Yang R,Chen BA* et al.Apoptosis selectively induced in BEL-7402 cells byfolic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field.Int J Nanomedicine2014;9:2043-2050.
19.XuP,Chen BA*,Feng J, Cheng L, Xia G, Li Yet al.Polymorphisms in XPC provide prognostic information in acute myeloid 白血病IntJ 血液學(xué)2012;96(4):450-460.
20.XuP, Li J,Chen BA*, Wang X, Cai X, Jiang Het al. The real-時(shí)間 neurotoxicityanalysis of 四氧化三鐵 nanoparticles combined with daunorubicin for rat brain invivoJBiomed Nanotechnology2012;8(3):417-423.
21.XuP, Li J, Shi L, Selke M,Chen BA*, Wang X. Synergetic effect of functionalcadmium-碲 quantum dots conjugated with gambogic acid for HepG2cell-labeling and proliferation inhibition. Int J Nanomedicine2013;8:3729-3736.
22.XuY, Wang Y, Li XM, Huang Q, Chen W, Liu R,Chen BA*et al. Study on the release of fenofibrate nanosuspension invitro and its correlation with in situ intestinal and in vivo absorptionkinetics in 家鼠屬Drug Dev Indus Pharmacy2014;40(7):972-979.
23.YangZ,Chen BA*,Pei X, Shangguan F. Multiplex analysis of tumor multidrug-resistance genesexpression with photonic suspension array.TheAnalyst2012;137(14):3343-3348.
24.ZhangH, Wang C,Chen BA*, Wang X. Daunorubicin-TiO2 nanocompositesas a "smart" pH-responsive drug delivery system. Int J Nanomedicine2012;7:235-242.
25.ZhongY, Wu J,Chen BA*, Ma R, Cao H, Wang Zet al. Investigation and analysis of single nucleotidepolymorphisms in Janus kinase/signal transducer and activator of transcriptiongenes with 白血病Leuk Lymphoma2012;53(6):1216-1221.
26. Zhang HJ,Chen BA*,Jiang H, Wang CL, Wang HP, Wang XM. A strategy for ZnO nanorod mediatedmulti-mode cancer treatment. Biomaterials. 2011; 32(7):1906-14.
27.Chen BA*, Wu WW, WangXM. Magnetic Iron 氧化物 Nanoparticles for Tumor-targeted Therapy. Curr CancerDrug Targets 2011; 11(2):184-9.
28. Zhang HJ, Jiang H, Sun FF, Wang HP, Zhao J,Chen BA*, Wang XM. Rapid diagnosis of multidrug resistance in cancerby electrochemical sensor based on 碳 nanotubes-drug supramolecularnanocomposites. Biosens Bioelectron. 2011; 26(7):3361-6.
29. Song M, Zhang RR, Dai YY, Gao F, Chi H, Lv G,Chen BA,* Wang XM. The in vitro inhibitionof multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition.Biomaterials. 2006; 27(23):4230-8.
30.Chen BA*, Yin L, ChengJ, Ding JH, Gao C, Sun YY, Zhao G, Wang J, Bao W, Xia GH, Gao F, Wang XM.Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1 -propanol andtetrandrine on the reversion of multidrug resistance in K562/A02 cells.血液學(xué) 2011; 16(1):24-30.
31. Wu WW,Chen BA*, ChengJ, Wang J, Xu WL, Liu LJ, Xia GH, Wei H, Wang XM, Yang M, Yang L, Zhang Y, XuC, Li J. Biocompatibility of 四氧化三鐵/DNR magnetic nanoparticles inthe treatmentof hematologic malignancies. Int J Nanomedicine. 2010; 5:1079-84.
32. Wang J, Chen Y,Chen BA*,Ding JH, Xia GH, Gao C, Cheng J, Jin N, Zhou Y, Li XM, Tang M, Wang XM.Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticlesin 鼠科 Int J Nanomedicine. 2010; 5:861-6.
33.Chen BA*, Mao P, ChengJ, Gao F, Xia GH, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Chen W, Chen N, LiuLJ, Li XM, Wang XM. Reversal of multidrug resistance by magnetic 四氧化三鐵nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression 向量 inleukemia cells. Int J Nanomedicine. 2010; 5:437-4.
34.Chen BA*, Jin N, WangJ, Ding JH, Gao C, Cheng J, Xia GH, Gao F, Zhou Y, Chen Y, Zhou G, Li XM, ZhangY, Tang M, Wang XM. The effect of magnetic nanoparticles of Fe(3)O(4) on immunefunction in normal ICR 鼠科 Int J Nanomedicine. 2010; 5:593-9.
35. Zhang HJ, Jiang H, Wang XM,Chen BA*. Reversion of multidrugresistance in tumor by biocompatible nanomaterials. Mini Rev Med Chem. 2010;10(8):737-45.
36. Zhong YJ,Chen BA*,Feng JF, Cheng L, Li Y, Qian J, Ding JH, Gao F, Xia GH, Chen N, Lu Z. Theassociations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomesin patients with acute myeloid 白血病. Leuk 淋巴瘤 2010; 51(6):1115-20.
37. Zhu XL, Zhang HJ, Lin Y, Chen P, Min J, Wang Z, Xiao W,Chen BA*. Mechanisms of gambogicacid-induced apoptosis in non-small cell lung cancer cells in relation to transferrinreceptors. J Chemother. 2009; 21(6):666-72.
38. Pei XP,Chen BA*, LiL, Gao F, Jiang Z. Multiplex tumor marker detection with new chemiluminescentimmunoassay based on silica colloidal 晶體 beads. Analyst. 2010; 135(1):177-81.
39.Chen BA*, Liang YQ, WuWW, Cheng J, Xia GH, Gao F, Ding JH, Gao C, Shao Z, Li G, Chen W, Xu WL, SunXC, Liu LJ, Li XM, Wang XM. Synergistic effect of magnetic nanoparticles ofFe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. Int J Nanomedicine.2009; 4:251-9.
40. Cheng J, Wu WW,Chen BA*,Gao F, Xu WL, Gao C, Ding JH, Sun YY, Song HH, Bao W, Sun XC, Xu C, Chen W,Chen N, Liu LJ, Xia GH, Li XM, Wang XM. Effect of magnetic nanoparticles of四氧化三鐵 and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02leukemic cells. Int J Nanomedicine. 2009; 4:209-16.
41. Pei XP, Zhao Y, Zhao X, Xu H,Chen BA*, Gu ZZ. Multiplex chemiluminescent immunoassay based onsilica colloidal 晶體 beads. J N N. 2009; 9(11):6320-5.
42. Sun N, Sun XC,Chen BA*,Cheng H, Feng JF, Cheng L, Lu ZH. MRP2 and GSTP1 polymorphisms and chemotherapyresponse in advanced non-small cell lung cancer. Cancer Chemoth Pharm. 2010;65(3):437-46.
43. Li Y, Deng Z, Xuan H, Zhu J, Ding B, Liu X,Chen BA*. Prolonged chronic phase in chronic myelogenous leukemiaafter homoharringtonine therapy. Chin Med J (Engl). 2009;122(12):1413-7.
44. Jiang Z,Chen BA*, XiaGH, Wu Q, Zhang Y, Hong T, Zhang W, Cheng J, Gao F, Liu LJ, Li XM, Wang XM. Thereversal effect of magnetic 四氧化三鐵 nanoparticles loaded with cisplatin onSKOV3/DDP ovarian carcinoma cells. Int J Nanomedicine. 2009; 4:107-14.
45.Chen BA*, Cheng J, WuYN, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G, ChenW, Chen N, Liu LJ, Li XM, Wang XM. Reversal of multidrug resistance by magnetic四氧化三鐵 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine inxenograft nude-mice. Int J Nanomedicine. 2009; 4:73-8.
46.Chen BA*, Cheng J,Shen MF, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G,Chen W, Chen N, Liu LJ, Li XM, Wang XM. Magnetic nanoparticle of 四氧化三鐵 and5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin inleukemia cells. Int J Nanomedicine. 2009; 4:65-71.
47.Chen BA*, Dai YY, WangXM, Zhang R, Xu WL, Shen HL, Gao F, Sun Q, Deng X, Ding JH, Gao C, Sun Y, ChengJ, Wang J, Zhao G, Chen N. Synergistic effect of the combination of nanoparticulate四氧化三鐵 and Au with daunomycin on K562/A02 cells. Int J Nanomedicine. 2008;3(3):343-50.
48.Chen BA*, Sun Q, WangXM, Gao F, Dai YY, Yin Y, Ding JH, Gao C, Cheng J, Li JY, Sun XC, Chen N, XuWL, Shen HL, Liu D. Reversal in multidrug resistance by magnetic nanoparticleof 四氧化三鐵 loaded with adriamycin and 漢防己甲素 in K562/A02 leukemic cells. IntJ Nanomedicine. 2008; 3(2):277-86.
獲得榮譽(yù)
先后獲教育部科技進(jìn)步二等獎(jiǎng)、江蘇省科技進(jìn)步二等獎(jiǎng)。國(guó)家級(jí)課題5項(xiàng)，省部級(jí)二等獎(jiǎng)3項(xiàng)。
獲得專利
1.王雪梅，張仁云，呂剛，吳春惠，李景源，高峰，程堅(jiān)，陳寶安，付德剛，李小毛，
關(guān)之群. 治療白血病的靶向磁性納米藥物及制備方法. 專利號(hào)：ZL 2005 1 0040657.1。
2.王雪梅，吳春惠，宋敏，李景源，張仁云，吳德洪，燕紅，顧忠澤，陳寶安. 有機(jī)金
屬碳硼烷靶向納米制劑的制備方法及制成的靶向制劑. 專利號(hào)： ZL 2006 1 0096423.3。
個(gè)人作品
個(gè)人貢獻(xiàn)
主編《惡性腫瘤多藥耐藥的逆轉(zhuǎn)》一部，參編著作多部，主持國(guó)家自然科學(xué)基金5項(xiàng)、參與“973”、“863” 、科技支撐等多項(xiàng)研究項(xiàng)目。
累計(jì)發(fā)表學(xué)術(shù)論文400余篇，其中SCI收錄近百篇，主（參）編著作3部。
參考資料 >
東南大學(xué)教師個(gè)人主頁(yè).東南大學(xué)教師個(gè)人主頁(yè).2014-11-05