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劉中秋
來源:互聯網

劉中秋,男,博士,現任廣州中醫藥大學副校長,是一位二級教授和博士生導師。

人物經歷

教育經歷

2003-2006:香港浸會大學中醫藥學院中藥學專業,獲博士學位;

1988-1992:廣州中醫藥大學中藥學院中藥學專業,獲學士

工作經歷

2020-至今:廣州中醫藥大學副校長;

2017-2020:廣州中醫藥大學中藥學院院長;

2013-現今:廣州中醫藥大學國際中醫藥轉化醫學研究所所長;

2007-2013:南方醫科大學藥學院副院長;

2006-2007:香港浸會大學中醫藥學院,博士后

2004-2005:美國休斯頓大學藥學院藥理藥劑學系,訪問學者

2003-2006:香港浸會大學博士研究生,博士研究生;

2001-2002:香港中文大學生物系,研究助理;

1992-2003:廣州中醫藥大學新藥開發研究中心,助理研究員。

政協廣東省第十一屆、十二屆委員會委員,政協第十三屆廣東省委員會常務委員。

社會任職

現兼任廣東省藥學會藥物制劑專業委員會副主任委員等17個學術團隊職務。國際期刊《Pharmacological Research》編輯、《Molecular Pharmaceutics》客座編輯,《中藥材》和《中草藥》雜志編委。國家百千萬人才工程、有突出貢獻中青年專家,廣東省高等學校珠江學者特聘教授,廣東省領軍人才。

任免信息

2020年8月,被任命為廣州中醫藥大學副校長,試用1年。

研究方向

● 影響藥物生物利用度的生理屏障及機理研究

● 基于藥物吸收與代謝原理的新型給藥傳遞系統研究

獲得榮譽

基于生物利用度屏障的中藥及復方功效評價方法的創新及應用,2019年廣東省科技進步獎一等獎

抑制細胞增殖與分化異常的新機制研究,2018年度教育部高等學校科學研究優秀成果自然科學獎一等獎。

主要成就

劉中秋教授長期從事中藥藥代動力學和中藥藥劑學研究。提出了“肝腸三循環”新理論,為中藥功效精準評價和中藥質量研究提供新原理與新方法。國際期刊上發表論文200余篇, H-Index為38;競爭性獲取縱向科研經費近4000萬元,主持國家自然科學基金課題8項(其中4項為重點項目),國家科技部課題3項,省部級課題10多項;獲廣東省科技進步一等獎、廣東省教學成果二等獎,參獲國家科技進步二等獎、教育部自然科學一等獎等。主編中國醫藥集團有限公司出版社《中藥藥劑學》教材英文版,副主編中國醫藥出版社"十三五"規劃教材和參編人民衛生出版社"十二五"、"十三五"規劃教材《生物藥劑學與藥代動力學》等,參編專著8部。

主持課題

“解毒-通脈”中藥毛冬青抗心肌缺血再灌注損傷的“多靶點-多成分互作”網絡調控機制研究[批準號:81930114],國家自然科學基金重點項目,297萬元,2020/01-2024/12;

基于體內暴露的中藥附子質量標示物的挖掘、確證與應用[批準號:2017YFE0119900],中華人民共和國科技部國家重點研發計劃,95萬元,2019/01-2021/12;

肝腸三循環調控黃酮和含黃中藥干預大腸癌的分子機制[批準號:81720108033],國家自然科學基金重點國際(地區)合作研究項目,234萬元,2018.1-2022.12;

益母草堿的產業化和臨床研究與開發(益母草堿的臨床藥代研究),[批準號:2017ZX09301002],中華人民共和國科技部國家科技重大專項,200萬元,2017/01-2020/12,子課題負責人;

中醫藥防治腫瘤轉化醫學研究聯合實驗室,中華人民共和國教育部,2017/01-2019/12。

學術成果

主持及參與完成的多項科研課題,均以考核優異結題,發表學術論文多篇,其中SCI收錄10余篇,所承擔本科生教學工作,在教學督導中獲評優秀,指導學生省級創新創業訓練項目2項,校級2項; 指導學生參加課題設計大賽并獲獎,獲得2018年本科生優秀畢業論文指導教師。

發表論文

. L. Hu, Z. Cao, L. Ma, Z. Liu, G. Liao*, J. Wang*, S. Shen, D. Li, X. Yang*. The potentiated checkpoint blockade 免疫治療 by ROS-responsive nanocarrier- mediacted cascade chemo-photodynamic therapy. Biomaterials, 2019, 23, 119469.

.Guochao Liao*, Jiatong Guo, Deying Yang, Zhifang Zhou, Zhongqiu Liu, and Zhongwu Guo*. Synthesis of a dimer of the repeating unit of type Ia Group B 鏈球菌 extracellular capsular 多糖 and immunological evaluations of related protein conjugates. Org. Chem. Front. 2019, 6, 2833-2838.

.Wang LP, Sun RJ, Zhang QS, Luo Q, Zeng SJ, Li XY, Gong X, Li YH, Lu LL, Hu M, Liu ZQ*, An update on polyphenol disposition via coupled metabolic 神經通路s. Expert Opinion on Drug 新陳代謝 & 毒理學, 2019, doi: 10.1080/17425255.2019.1559815.

.Li YH, Lu LL, Wang LP, Qu Wei, Liu WQ, Xie YS, Zheng HM, Wang Y, Qi XX, Hu M, Zhu LJ, Liu ZQ, Interplay娛樂 of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with 山柰酚 Molecular Pharmaceutics, 2018, 15 (12):5602-5614.

.Su T#, Li FY#, Guan JJ, Liu LX, Huan P, Wang Y, Qi XX, Liu ZQ, Lu LL*, Wang DW*. Artemisinin and its derivatives prevent Helicobacter pylori-induced gastric carcinogenesis via 性抑制 of NF-kappa B 信令. Phytomedicine, 2019, 63

.Feng Q#, Wang HJ#, Pang JY, Ji LY, Han JD, Wang Y, Qi XX, Liu ZQ*, Lu LL*. Prevention of Wogonin on Colorectal Cancer Tumorigenesis by Regulating p53 Nuclear Translocation. Frontiers in 藥理學, 2018, 9: 1356.

.Su T#, Yang X#, Deng JH, Huang QJ, Huang SC, Zhang YM, Zheng HM, Wang Y, Lu LL*, Liu ZQ*. Evodiamine, a novel NOTCH3 methylation stimulator, significantly suppresses lung carcinogenesis in vitro and in vivo Frontiers in 藥理學, 2018, 9: 434.

.Zheng HM#, Huang QJ#, Huang SC, Yang X, Zhu T, Wang WS, Wang HJ, He SG, Ji LY, Wang Y, Qi XX, Liu ZQ*, Lu LL*. Senescence inducer Shikonin ROS-dependently suppressed lung cancer progression. Frontiers in 藥理學, 2018, 9:519.

.He SG#, Ou RL#, Wang WS, Ji LY, Gao H, Zhu YF, Liu XM, Zheng HM, Liu ZQ, Wu P*, Lu LL*. Camptosorus 長尾朱雀 rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and 脫氧核糖核酸 damage. Journal of Ethnopharmacology, 2018, 220:44-56.

.Lv SD#, Ji LY#, Chen B, Liu SQ, Lei CY, Liu X, Qi XX, Wang Y, Leung ELH, Wang HY, Zhang L, Yu XM, Liu ZQ*, Wei Q*, Lu LL*. Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4. 癌基因, 2018, 37(10):1354-1368.

.Wu JJ, Zhu YF, Guo ZZ, Lou YM, He SG, Guan Y, Zhu LJ, Liu ZQ, Lu LL*, Liu L*. Aconitum alkaloids, the major components of Aconitum 物種, affect expression of multidrug 厚膜電阻-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling 神經通路 Phytomedicine, 2018, 44:87-97.

.Zou J#, Li H#, Huang QL, Liu XM, Qi XX, Wang Y, Lu LL*, Liu ZQ*. Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma. Tumor Biology, 2017, 39(10):1010428317719272.

.Kou Y#, Ji LY#, Wang HJ, Wang WS, Zheng HM, Zou J, Liu LX, Qi XX, Liu ZQ, Du BY*, Lu LL*. Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization. International Journal of Cancer, 2017, 141(8):1690-703.

.Zhang QS, Zhu LJ, Gong X, Ruan YJ, Yu J, Jiang HY, Wang Y, Qi XX, Lu LL*, Liu ZQ*. Sulfonation disposition of acacetin: in vitro and in vivo Journal of Agricultural and Food 化學, 2017, 65(24):4921-31.

.Yu J#, Zhu LJ#, Zheng HH, Gong X, Yu JH, Chen JM, Li YH, Zheng HM, Qi XX, Wang Y, Hu M, Lu LL*, Liu ZQ*. Sulfotransferases and 乳房 Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in vivo Molecular Pharmaceutics, 2017, 14(9):2917-2929.

.Shi J#, Zhu LJ#, Li Y, Zheng HH, Yu J, Lu LL*, Liu ZQ*. In vitro study of UGT 新陳代謝 and permeability of orientin and isoorientin, two active flavonoid C-glycosides. Drug Metabolism Letters, 2016;10(2):101-10.

.Liu YT#, Tong YL#, Yang X, Li FY, Zheng L, Liu WQ, Wu JJ, Ou RL, Zhang GY, Hu M, Liu ZQ*, Lu LL*. Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer. Pharmacological Research, 2016, 111:113-125.

.Zhang GY, Ou RL, Li FY, Wu JJ, Zheng L, Tong YL, Liu YT, Liu ZQ*, Lu LL*. Regulation of drug-metabolizing enzymes and efflux transporters by Astragali radix decoction and its main bioactive 化合物s: Implication for clinical drug-drug interactions. Journal of Ethnopharmacology, 2016, 180:104-13.

.Tong YL#, Liu YT#, Zheng HM, Zheng L, Liu WQ, Wu JJ, Ou RL, Zhang GY, Li FY, Hu M, Liu ZQ*, Lu LL*. Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/b-catenin 信令 Oncotarget, 2016, 7(21):31413-28.

.Zheng L#, Zhu LJ#, Zhao M, Shi J, Li YH, Yu J, Jiang HY, Wu JJ, Tong YL, Liu YT, Hu M, Lu LL*, Liu ZQ*. In vivo exposure of 山柰酚 is driven by phase II metabolic enzymes and efflux transporters. The AAPS Journal, 2016, 18(5):1289-99.

.Huang ZY, Huang QJ, Ji LY, Wang Y, Qi XX, Liu L, Liu ZQ*, Lu LL*. Epigenetic regulation of active 漢語詞類 草本al components for cancer prevention and treatment: A follow-up review. Pharmacological Research, 2016, 114:1-12.

.Wu JJ, Na L, Li FY, Zhang GY, He SG, Zhu YF, Ou RL, Li N, Liu SQ, Feng LZ, Liu L, Liu ZQ, Lu LL*. Induction of P-glycoprotein expression and activity of by aconitum alkaloids: implication for clinical drug–drug interactions. Scientific Reports, 2016, 6:25343.

.Wu JJ, Zhu YF, Li FY, Zhang GY, Shi J, Ou RL, Tong YL, Liu YT, Liu L, Lu LL*, Liu ZQ*. Spica prunellae and its 馬克筆 compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in HepG2 cells. Journal of Ethnopharmacology, 2016, 193:1-11.

.Feng LZ#, Huang QJ#, Huang ZY, Li H, Qi XX, Wang Y, Liu ZQ, Liu XH*, Lu LL*. Optimized 動物界 model of Cyclophosphamide-induced bone marrow suppression. Basic & Clinical 藥理學 & 毒理學, 2016, 119(5):428-435.

.Shi J, Zheng L, Lin ZF, Hou CQ, Liu WQ, Yan TM, Zhu LJ, Wang Y, Lu LL*, Liu ZQ*. Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat 等離子體 following oral administration of the H?O extract of Astragali radix using UPLC-MS/MS. Journal of Ethnopharmacology, 2015, 169:183-194.

.Dai PM#, Zhu LJ#, Yang XS, Zhao M, Shi J, Wang Y, Lu LL*, Liu ZQ*. Multidrug 厚膜電阻associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells. Life Sciences, 2015, 127(2015):66-72.

.Wu JJ#, 成姓 ZX#, He SG, Shi J, Liu SQ, Zhang GY, Zhu LJ, Liu L, Liu ZQ, Lin N, Lu LL*. Pinelliae rhizoma, a toxic 漢語詞類 草本, can significantly inhibit CYP3A activity in 家鼠屬 Molecules, 2015, 20(1):792-806.

.Lin ZF, Liu YT, Li FY, Wu JJ, Zhang GY, Wang Y, Lu LL*, Liu ZQ*. Anti-lung cancer effects of polyphyllin VI and VII potentially correlate with apoptosis in vitro and in vivo Phytotherapy Research, 2015, 29(10):1568-1576.

.Liu WQ#, Shi J#, Zhu LJ, 越南盾 LN, Luo FF, Zhao M, Wang Y, Hu M, Lu LL*, Liu ZQ*. Reductive 新陳代謝 of oxymatrine is catalyzed by microsomal CYP3A4. Drug 設計 Development and Therapy, 2015, 9:5771-5783.

.Wu JJ#, 成姓 ZX#, Chen H, Zhang GY, He SH, Liu SQ, Lin ZF, Zhu LJ, Liu ZQ, Na L*, Lu LL*. The significant 性抑制 on CYP3A caused by radix Aconiti single herb is not observed in the Wutou decoction: The necessity of 組合 therapy of radix Aconiti. Journal of Ethnopharmacology, 2015, 170:251-254.

參考資料 >

劉中秋.廣州中醫藥大學中藥學院(新).2021-11-09

政協廣東省第十一屆委員會委員名單.人民網.2023-01-14

廣東省政協第十二屆委員名單.廣東政協網.2023-01-14

政協第十三屆廣東省委員會主席、副主席、秘書長和常務委員名單.云浮發布-今日頭條.2023-01-13

廣東任免孫哲、谷青云、支光南、金圣宏、何少青、鄭惠典等職務.中國經濟網.2020-09-01

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