李曉江，中國科學院遺傳與發育生物學研究所分子發育生物學國家重點實驗室，博士生導師。研究成果發表于《Nature》 《Nature Genetics》等國際核心刊物100余篇，累計引用率達到12000余次，h-index高達62。2008年起任華中科技大學基礎醫學院講座教授；2010年入選中組部（中科院遺傳發育所）。李曉江博士還兼任華中科技大學，中南大學與蘇州大學的客座教授。
學習經歷
1977-1982年，南昌大學江西醫學院醫學專業學士
1987-1991年，美國Oregon Health Science University 藥理學博士
1991-1995年，美國Johns Hopkins University 神經學科博士后
工作經歷
1995-1996年，美國Johns Hopkins University精神病學系助理教授
1996-2001年，美國Emory大學人類遺傳學系助理教授
2001-2005年，美國Emory大學人類遺傳學系終身副教授
2005年起，美國Emory大學人類遺傳學系終身教授
2007年起，美國Emory大學Distinguished The Professor of Human Genetics (杰出講席教授)
2008年起，華中科技大學基礎醫學院講座教授
2010年入選中組部（中國科學院遺傳與發育生物學研究所）
主要成果
李曉江的主要成果有：2008年在世界上首次利用轉基因方法建立了非人靈長目的塞繆爾·亨廷頓疾病模型；2015年制備出首例帕金森病的轉基因猴模型，并利用CRISPR/Cas9技術制備了首例杜氏肌營養不良癥及孤獨癥猴模型；2018年建立的世界首例亨廷頓基因敲入豬模型的研究成果發表在國際頂級期刊《Cell》雜志，受到國內外的高度好評和關注；研究成果發表于Cell，Nature，Nature Genetics，Nature Medicine，PNAS等國際核心刊物180篇，總影響因子達1388，H指數為63，累計引用率達14221余次。
主要研究方向
1．遺傳性神經退行性疾病的病理機制研究。
2．細胞內轉運與早期神經系統的發育。
代表性研究論文
Bhat KP, Yan S, Wang CE, Li SH,Li X-J. Differential ubiquitination and degradation of huntingtin fragments modulated by E3 ligase Ube3a. Proc Natl Acad Sci U S A, 2014; published ahead of print March 31, 2014, doi:10.1073/pnas.1402215111
Yang HQ, Wang GH, Sun HT, Shu RZ, Liu T, Wang CE, Liu ZM, Zhao Y, Zhen QY, Yang DS, Huang J, Zhou YL, Li SH, Jiang XD, Xiao ZC,Li X-J*, Lai LX. Species-dependent neuropathology in transgenic SOD1 pigs. Cell Res 2014 Feb 28. doi: 10.1038/鉻2014.25. [Epub ahead of print] (*Corresponding author)
Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S,Li X-J.TDP-43 causes differentialpathology in neuronal versus glial cells in the mouse brain. Hum 摩爾 Genet. 2014 Jan 10. [Epub ahead of print]
Su Y, Huang SS, Gaertig MA,Li X-J*, Li sh Age-dependent decrease in chaperone activity impairs MANF expression leading to Purkinje cell degeneration in inducible SCA17 鼠科 Neuron,81,349–365 2014 (*Corresponding author)
Xiang JX, Yang H, Zhao T, Sun M, Xu XS, Zhou X.F., Li SH,Li X-J. Hunting錫Associated Protein 1 is essential for postnatal growth by regulating neurogenesis. J Clin Invest. 124(1):85-98. 2014
Xu Q.Q., Huang S.S., Song M.K., Wang C.E. Yan S., Liu X.D., Gaertig M.A., Yu. S.P., Li H., Li S.H.,Li X-J. Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J. 細胞 Biol. 202:1123-1138, 2013.
Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S,Li XJ. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J Neurosci. 33:8172-84. 2013.
Cape A, Chen XX, Wang CE, O’Neill A, Lin YF, He J, Xu XS, Yi H, Li H, Li SH,Li X-J. Loss of hunting錫associated protein 1 impairs 胰島素 secretion from pancreatic beta cells. Cell 摩爾 Life Sci, 69:1305-17. 2012.
Wang H, Huang Z, Huang L, Niu S, Rao X, Xu J, Kong H, Yang J, Yang C, Wu D, Li S,Li XJ, Liu T, Sheng G. Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C 捕手 J Biol Chem. 287(3):2237-46. 2012
Mandal M, Wei J, Zhong P, Chen J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S,Li XJ, Kittler JT, Yan Z. Impaired AMPA receptor trafficking and function by mutant Huntingtin. J Biol Chem. 286:33719-28. 2011.
Huang SS, Ling JJ, Yang S.Li X-J*, Li SH. Neuronal expression of TATA box binding protein containing expanded polylgutamine in knock-in mice reduces chaperone protein response by impairing the 函數 of NF-Y transcription factor. Brain 134(Pt 7):1943-58, 2011 (*Corresponding author)
Havel LS, Wang CE, Huang B, Wade B, Li SH,Li X-J. Preferential localization of N-terminal mutant huntingtin in striatal neurons cause neurological symptoms and is regulated by phosphorylation. Hum 摩爾 獛屬 20:1424-37, 2011
Xu XS, Yang H, Lin Y.F., Li X, Cape A, Ressler KJ, Li SH,Li X-J. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in 鼠科 alters TrkB signaling with a depressive phenotype.Proc Natl Acad Sci U S A. 107:19126-31, 2010
Yang DS, Wang CE, Zhao BT, Li W, Quyan Z, Liu ZM, Yang HQ, O’Neill A, Yi H, Li SH,Lai LX,Li X-J. Expression of Huntington disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum. 摩爾 Genet, 19:3983-94, 2010
Lin YF, Xu XS, Cape A, Li SH,Li XJ. Hap1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mICE J Biol Chem. 285:15941-9, 2010.
Bradford J, Shin J-Y, Roberts M, Wang C-E, Sheng G-Q, Li SH, Li X-J. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease 鼠科 J Biol Chem. 285:10653-61, 2010.
Bradford J, Shin J-Y, Roberts M, Wang C-E,Li X-J, Li SH. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci USA. 106:22480-5,
Friedman MJ, Li S,Li X-J. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. J Biol Chem. 284:27944-51, 2009
Orr AG, Orr AL,Li X-J, Gross RE, Traynelis SF. 腺苷 A2A receptor mediates microglial process retraction. Nature Neurosci. 12:872-8, 2009.
Shah A, Freidman M. Huang SS, Roberts M,Li X-J, Li SH Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Hum 摩爾 獛屬 18: 4141-52, 2009.
Tydlacka S, Wang CE, Wang XJ, Li SH,Li X-J. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J. Neurosci. 28: 13285-13295, 2008
Wang CE, Tydlacka S, Adam OL, Yang SH, Graham RK, Hayden MR, Li SH, Chan AW,Li X-J. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington’s disease. Hum. 摩爾. 獛屬 17: 2738-2751, 2008
Sheng GQ, Xu XS, Lin YF, Wang CE, Rong J, Peng J, Jiang X, Li SH,Li X-J. Hunting錫associated protein 1 interacts with Ahi1 to regulate cerebellar and 腦干 development in 鼠科 J Clin Invest 118:2785-95, 2008
Wang CE, Zhou H, McGuire JR, Cerullo V, Lee B, Li SH,Li X-J. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic 毒性 of mutant huntingtin. J. 細胞 Biol. 181: 803-816, 2008
Orr AL, Huang SS, Robert MA, Reed JC, Li SH,Li X-J. Sex-dependent effect of BAG1 in ameliorating 摩托車 deficits of huntington’s disease transgenic 鼠科 J. Biol. Chem. 283:16027-36, 2008
Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Larkin K, Snyder B, Cheng ECH, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH,Li X-J, Chang AWS. Toward a transgenic model of Huntington’s disease in a non-human 靈長目 Nature 453: 921-924, 2008
Orr AL, Li SH, Wang CE, Li H, Rong J, Xu XS, Mastroberardino PJ, Greenamyre TJ,Li X-J. N-terminal Mutant Huntingtin Associates with Mitochondria Directly and Disrupts the Interaction of Mitochondria with Trafficking Proteins. J. Neurosci. 28: 2783-92, 2008
Wang JJ, Wang CE, Orr A, Tydlacka S, Li SH,Li X-J. Impaired ubiquitin-proteasome system activity in the synapses of Huntington disease mice. J. Cell Biol. 180: 1177-89, 2008.
Friedman MJ, Wang CE,Li XJ, Li SH. Polyglutamine expansion reduces the association of TBP with 脫氧核糖核酸 and induces DNA binding-independent neurotoxicity. J Biol Chem. 283: 8283-90, 2008
Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn A, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH,Li XJ*, Riess O. Hunting錫associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Hum Mol 獛屬 17: 1137-46, 2008 (*Corresponding author)
Friedman M., Fang ZH., Shah A., Goursac L., Warren S., Li SH.,Li X-J. Polyglutamine domain regulates the TBP-TFIIB interaction: implications for its normal 函數 and neurodegeneration. Nature 神經科學 10: 1519-28, 2007
社會職務
李曉江擔任的社會職務為：重慶醫科大學腦科學與腦疾病研究院學術顧問委員會。
參考資料 >
李曉江.jysw.suda.edu.cn.2024-04-22
【2024年4月17日】學術講座:華中科技大學李曉峰教授講座.中國地質大學藝術與傳媒學院.2024-04-22
深度調查丨李曉江事件背后:美國處罰華人科學家的真實邏輯.風聞社區.2024-04-22
暨南大學李曉江教授和閆森研究員為我校師生做專題講座.云南農業大學.2024-07-21