伍一軍,男,安徽桐城人,畢業(yè)于佐治亞州醫(yī)學(xué)院分子醫(yī)學(xué)與遺傳學(xué)系基因調(diào)控專業(yè),現(xiàn)為中國科學(xué)院動(dòng)物研究所分子毒理學(xué)研究組組長、研究員,中國科學(xué)院大學(xué)兼職教授、博士研究生導(dǎo)師,中國昆蟲學(xué)會(huì)第八屆理事會(huì)常務(wù)理事、副秘書長。
人物經(jīng)歷
伍一軍現(xiàn)任中國科學(xué)院動(dòng)物學(xué)研究所研究員,博士研究生導(dǎo)師,主持分子毒理學(xué)實(shí)驗(yàn)室。中國科學(xué)院研究生院/動(dòng)物研究所獲得理學(xué)博士學(xué)位后赴美國Medical College of Georgia分子醫(yī)學(xué)與遺傳學(xué)系完成博士后研究訓(xùn)練。先后赴Jniversity of Louisiana、俄勒岡大學(xué) Health&Science University、Duke University、Virginia Commonwealth University等高校作為高級(jí)研究學(xué)者從事訪問研究和合作研究。
正文
個(gè)人簡介
伍一軍,安徽桐城人。佐治亞州醫(yī)學(xué)院分子醫(yī)學(xué)與遺傳學(xué)系基因調(diào)控專業(yè)博士后?,F(xiàn)為中國科學(xué)院動(dòng)物研究所分子毒理學(xué)研究組組長、研究員,中國科學(xué)院大學(xué)兼職教授、博士研究生導(dǎo)師,中國昆蟲學(xué)會(huì)第八屆理事會(huì)常務(wù)理事、副秘書長。主持分子毒理學(xué)實(shí)驗(yàn)室,專業(yè)方向?yàn)榉肿佣纠韺W(xué),主要研究領(lǐng)域?yàn)樯窠?jīng)毒理學(xué)、環(huán)境毒理學(xué)以及藥物引起的神經(jīng)疾病。主要研究興趣在于環(huán)境有害化學(xué)物質(zhì)的神經(jīng)毒性機(jī)制、神經(jīng)病靶標(biāo)酶引發(fā)遲發(fā)性神經(jīng)毒性的分子機(jī)理、低劑量環(huán)境化學(xué)物質(zhì)的致癌機(jī)理、溶血性貧血卵磷脂及泛蛋白調(diào)節(jié)在神經(jīng)毒性發(fā)生過程中的作用等。先后主持中國科學(xué)院重點(diǎn)項(xiàng)目、國家自然科學(xué)基金項(xiàng)目、中科院生物特別支持項(xiàng)目、院創(chuàng)新項(xiàng)目和國際合作項(xiàng)目,并承擔(dān)中科院創(chuàng)新重大項(xiàng)目和國家863專題項(xiàng)目。
主要論著
國際核心源刊物(SCI)
1.Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit iNTEracts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.
2.Li XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced ca(clo)2+response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80(6):886-892.
3.Li XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett, 2007, 424:22-26.
4.Chen R, Chang PA, Long DX, Yang L, Wu YJ. Down-regulation of neuropathy target esterase by protein kinase C activation with PMA stimulation. Mol Cell Biochem. 2007, 302:179-185.
5.Yang L, Liu J, Wu YJ, Li W, Gao XW, Leng XF. Oral administrations of 甲胺磷 and TOCP have different effects on in vitro protein phosphorylation levels from subcellular fractions of hen brain. Pestic Biochem Physiol 2007, 88(1):20-25.
6.Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the nhancement of protein phosphorylation of 腦干 mitochondria and synaptosomes from the hens dosed with tri-o-cresyl 磷酸鹽 Environ Toxicol Pharmacol. 2007, 24(1):67-71.
7.Chang P-A, Long D-X, Wu Y-J. Molecular cloning and expression of chicken neuropathy target esterase activity domain. Toxicol. Lett. 2007, 174(1-3):42-48.
8.Chang PA, Long DX, Wu YJ. Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase. Mol Cell Biochem. 2007, 306:25-32
9.Li Q, Chen R, Li W, Qiao C-L, Wu Y-J. A genetically engineered 埃希氏菌屬 coli, expressing the fusion protein of green fluorescent protein and carboxylesterase B1, can be easily detected in the environment following degradation of pesticide residues. Biotechnol Lett. 2007, 29(9): 1357-1362.
10.Li W, Wu Y-J,Qin D-M,Ma Y,Sun Y-J,Qiu S-P.A method for quantifying azoxystrobin residues in grapes and soil using a gas chromatography capture detector. Chromatographia.2008, 67:761-766.
11.Li W, Qiu S-P, Wu Y-J. Triazophos residues and dissipation rates in wheat crops and soil. Ecotoxicol Environ Saf. 2008, 69:312-316.
12.Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159(1): 65-72.
13.Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39(5): 429-440.
14.Chang PA, Wu YJ. Effect of tri-o-cresyl 磷酸鹽 on 細(xì)胞骨架 in human neuroblastoma SK-N-SH cell. Mol Cell Biochem. 2006, 290: 145-151.
15.Chang PA, Chen R, Wu YJ. Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) 細(xì)胞 line. 摩爾 Brain Res 2005, 151: 30-38.
16.Chang PA, Wu YJ, Chen R, Li M, Li W, Qin QL. Inhibition of neuropathy target esterase expressing by antisense 核糖核酸 does not affect neural differentiation in human neuroblastoma (SKNSH) cell line. 摩爾 Cell Biochem 2005, 272: 47-54.
17.Chang P-A, Wu Y-J. Inhibition of the expression of neuropathy target esterase in human neuroblastoma cell SH-SY5Y by antisense 核糖核酸 and RNA interference. Acta Biochimica et Biophysica Sinica. 2004, 36(2):156.
18.Wu YJ, Harp P, Yan XR, Pope .cn Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterase. Chem-Biol Interact. 2003, 142(3):255-268.
19.Nozell S, Wu YJ, McNaughton K, Liu G, Willis A, Park JS, Chen XB. Characterization of p73 functional domains necessary for transactivation and growth 壓制火炮 Oncogene, 2003, 22:4333-4347.
20.Wu YJ, Chang PA, Li M, Li YX, Li W. Effect of tri-O-cresyl 磷酸鹽 and 甲胺磷 on 45CA uptake by brain synaptosomes in hens. Pestic Biochem Physiol. 2003, 77(1):18-23.
中文核心期刊
1.常平安,陳瑞,李薇,伍一軍. 構(gòu)建人神經(jīng)病靶標(biāo)酯酶RNAi表達(dá)載體抑制哺乳動(dòng)物細(xì)胞中NTE的表達(dá). 中華勞動(dòng)衛(wèi)生職業(yè)病雜志, 2006,24(1):27-30.
2.常平安,伍一軍. 有機(jī)磷引起的遲發(fā)性神經(jīng)病的發(fā)生機(jī)制。中華勞動(dòng)衛(wèi)生職業(yè)病雜志, 2006,24(6):382-384.
3.劉杰,高希武,伍一軍. 化學(xué)殺蟲劑對(duì)松墨天牛體內(nèi)代謝酶的作用. 農(nóng)藥, 2006,45(8):542-544.
4.常平安,倪小敏,伍一軍. 綠色熒光蛋白標(biāo)記的NTE活性域表達(dá)載體的構(gòu)建及表達(dá). 重慶郵電大學(xué)學(xué)學(xué)報(bào)(自然科學(xué)版), 2006,18(3):416-419.
5.李薇,伍一軍,仇紹萍,王睿,冷欣夫. 吡蟲啉在蘿卜及土壤中的殘留動(dòng)態(tài)研究. 農(nóng)藥, 2006,45(12):840-841.
6.龍鼎新,伍一軍,李薇,王琦,秦啟聯(lián) 8種化學(xué)藥劑單獨(dú)及兩兩聯(lián)合染毒對(duì)松材線蟲殺滅作用試驗(yàn). 浙江林業(yè)科技, 2006, 26(5):39-42.
7.陳瑞,王仲文,伍一軍. 電離輻射引發(fā)細(xì)胞凋亡的信號(hào)通路. 世界科技研究與發(fā)展, 2005,27(1):49-51.
8.伍一軍,楊琳,李薇. 有機(jī)磷農(nóng)藥的多毒性作用. 環(huán)境與職業(yè)醫(yī)學(xué), 2005,22(4):367-370.
9.楊琳,劉杰,李薇,伍一軍. 甲胺磷誘發(fā)母雞遲發(fā)性神經(jīng)毒性模型. 動(dòng)物學(xué)雜志,2005,40(4):12-16.
10.常平安,陳瑞,李薇,伍一軍. NTE酯酶活性區(qū)域真核生物表達(dá)載體的構(gòu)建及其表達(dá). 毒理學(xué)雜志, 2005,19(3):169-171.
11.伍一軍,陳瑞,李薇. 昆蟲仿生. 昆蟲知識(shí), 2005,42(1):109-112.
12.伍一軍,常平安,李薇,秦啟聯(lián),陳瑞,劉承蕓,冷欣夫。昆蟲神經(jīng)毒性酯酶活性的測(cè)定。昆蟲知識(shí), 2005,42(4):458-460.
13.伍一軍,陳瑞,劉承蕓,李薇. 農(nóng)藥殘留及其納米顆粒的毒性問題. 農(nóng)藥,2005,44(8):370-371-381.
14.常平安,伍一軍. 有機(jī)磷酸酯誘發(fā)的遲發(fā)性神經(jīng)病靶標(biāo)酯酶的老化機(jī)制. 中國藥理學(xué)與毒理學(xué)雜志, 2005,19(6):462-465.
15.伍一軍,劉杰,楊琳,李薇,高希武 松墨天牛美國白燈蛾體內(nèi)神經(jīng)毒性酯酶和乙膽堿酯酶對(duì)甲胺磷敏感性的比較. 昆蟲學(xué)報(bào),2006, 49(3):399-403.
16.陳瑞,楊琳,姚智,劉承云,李曉華,李琴,劉杰,常平安,李薇,伍一軍. 神經(jīng)病靶標(biāo)酯酶調(diào)控結(jié)構(gòu)域結(jié)合蛋白篩選及其在COS-7細(xì)胞中的表達(dá). 動(dòng)物學(xué)報(bào),2005,51(5):840-844.
17.常平安,李明,伍一軍。培養(yǎng)細(xì)胞在遲發(fā)性神經(jīng)毒性研究中的應(yīng)用。衛(wèi)生毒理學(xué)雜志,2002,16 (4):245-247.
18.李明,常平安,李玉俠,李薇,伍一軍。兩種有機(jī)磷酸酯對(duì)人成神經(jīng)細(xì)胞瘤細(xì)胞生長與鈣攝取的影響。中華勞動(dòng)衛(wèi)生職業(yè)病雜志,2003,21(3):200-202.
19.常平安,伍一軍。毒理蛋白質(zhì)組學(xué)。中華預(yù)防醫(yī)學(xué)雜志,2003,37(6):455-457.
20.伍一軍,冷欣夫。殺蟲脒藥劑的神經(jīng)毒理學(xué)研究進(jìn)展。昆蟲學(xué)報(bào),2003,46(3):382-389.
21.Li M, Wu Y-J, Leng X-F. Effects of verapamil on 腦干 microsomal protein phosphorylation in vitro in hens dosed with tri-o-cresyl 磷酸鹽 Chin J Pharmacol Toxicol 2002, 16(3): 165-171.
22.常平安,伍一軍。有機(jī)磷酸酯引起的遲發(fā)性神經(jīng)病的“強(qiáng)化”機(jī)理。中國藥理學(xué)與毒理學(xué)雜志,2002,16(4):316-420.
23.伍一軍。研究生創(chuàng)新思維和創(chuàng)新能力的培養(yǎng)。學(xué)位與研究生教育,2003,126(7):4-6.
24.冷欣夫、邱星輝、伍一軍。細(xì)胞色素P450酶系循環(huán)催化的新途徑。中國生物工程雜志,2002,22(5):49-52.
25.常平安,伍一軍. 丙胺磷對(duì)人成神經(jīng)細(xì)胞瘤SK-N-SH細(xì)胞分化的毒性機(jī)制. 中國藥理學(xué)與毒理學(xué)雜志,2006,20(6):494-499.
26.常平安 , 伍一軍. 反向重復(fù)序列法構(gòu)建神經(jīng)病靶標(biāo)酯酶rna干涉表達(dá)質(zhì)粒 毒理學(xué)雜志, 2007,21(1):4-8.
27.常平安,伍一軍. 神經(jīng)病靶標(biāo)酯酶的特性。生命的化學(xué),2004,24(5):424-426.
28.李曉華,龍鼎新,侯威遠(yuǎn),李薇,伍一軍. 溶血卵磷脂對(duì)小鼠及雞腦突觸體內(nèi)鈣離子濃度升高的影響. 動(dòng)物學(xué)報(bào), 2007, 49(3):399-403.
國際會(huì)議論文集論文
1. Liu J, Yang L, Li W, Gao XW, Wu YJ. Effects of Methamidophos and deltamethrin on protein phosphorylation of Monochamus alternatus Hope. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp97, China Agricultural University Press.
2. Yang L, Liu J, Li W, Wu YJ. The effect of 甲胺磷 on protein phosphorylation of adult hen’s brain. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp95, China Agricultural University Press.
3. Liu CY, Li W, Wu YJ. Study of apoptosis induced by 敵百蟲 in SH-SY5Y cells. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp100, China Agricultural University Press.
4. Li Q, Chen R, Li W, Qiao CL, Liu J, Liu CY, Li XH, Yang L, Wu YJ. Construction of GFP-marked genetically engineered bacteria used to degrade the pesticide residue in the environment. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing), (Editor-in-chief: Jiang Shuren), pp124, China Agricultural University Press.
5. Li W, Wu Y-J, Qin D-M, Ma Y, Qiu S-P. Determination of fungicide azoxystrobin residues in soil. In: Proceedings of 3rd International Symposium on Pesticide and Environmental Safety & 7th International Workshop on Crop Protection 化學(xué) and Regulatory Harmonization (October 9-13, 2007, Beijing, P. R. China) (Editor-in-chief: Jiang Shuren, Kenneth D. Racke), pp225-230, 2007. China Agricultural University Press.
6. Li Q, Chen R, Wu Y-J. Generation of pesticides-degrading genetically engineered bacteria expressing the protein of GFP and carboxylesterase B1. In: Proceedings of 3rd International Symposium on Pesticide and Environmental Safety & 7th International Workshop on Crop Protection 化學(xué) and Regulatory Harmonization (October 9-13, 2007, Beijing, P. R. China) (Editor-in-chief: Jiang Shuren, Kenneth D. Racke), pp203-212, 2007. China Agricultural University Press.
專著
1.伍一軍譯. 第26章 陸生動(dòng)物的毒液和毒素的毒效應(yīng). 見《卡薩瑞特道爾毒理學(xué):毒物的基礎(chǔ)科學(xué)》(第6版)(原著:Cartus D. Klaassen),黃吉武,周宗燦主譯。北京:人民衛(wèi)生出版社,2005:827-844.
2.彭雙清、郝衛(wèi)東、伍一軍.?《毒理學(xué)替代法》.北京:軍事醫(yī)學(xué)科學(xué)出版社,2009.
人才培養(yǎng)
伍一軍已培養(yǎng)畢業(yè)研究生24人,多人獲國家獎(jiǎng)學(xué)金和中科院獎(jiǎng)學(xué)金,畢業(yè)后赴美留學(xué)就業(yè)和博士后研究。國內(nèi)工作中3人晉升為教授和碩導(dǎo)、5人晉升為副教授/副研究員?,F(xiàn)有在讀博士生3人,碩士生3人(其中聯(lián)培生1人)。
參考資料 >