楊勝勇，教授，博士生導師。
人物介紹
2003年1月-2005年10月，加拿大卡爾加里大學研究助理，同時兼任Bayer公司高級研究員。
2005年10月通過985平臺進入四川大學華西醫院生物治療國家重點實驗室工作，主要從事藥物分子設計方法、先導化合物優化、靶向藥物設計、合成與開發等研究工作。
任職：
四川省藥學會藥物化學專委會 副主任委員。
四川省腫瘤學會靶向治療專委會 委員。
《Pharmacology & Pharmacy》 編委。
《J. Amer. Chem. Soc.》 特邀審稿人。
《J. Med. Chem.》 特邀審稿人。
《Proteins》 特邀審稿人。
《J. Chem. Inf. Mod.》 特邀審稿人。
《J. Theor. Comput. Chem.》 特邀審稿人。
《Eur. J. Med. Chem.》 特邀審稿人。
《Bioorg. Med. Chem. Lett.》 特邀審稿人。
研究方向
(1) 新型抗腫瘤靶向藥物的研發。
(2) 新型治療自體免疫性疾病疾病藥物的研發。
(3)?先導化合物優化與合成研究。
(4) 藥物分子設計新方法研究。
(5)?系統生物學。
主要貢獻
主持了包括863、國家創新藥物重大專項、國家自然科學基金、教育部新世紀優秀人才資助計劃、四川省杰出青年基金等多項國家和省部級項目。至今已在包括白血病, J. Amer. Chem. Soc., Clinica Cancer Res., Drug Disc. Today, J. Med. Chem., Plos ONE, Proteins, J. Comput. Chem., Organometallics, J. Phys. Chem. A 等國內外重要期刊上發表SCI研究論文100余篇。曾獲四川省科技進步獎一項。研究領域：計算機輔助藥物分子設計；計算生物學。
代表性論著：
支姓 Cao, Jing-Jing Liu, Ren-Lin Zheng, Jiao Yang, Lei Zhong, Yong Xu, Li-Jiao Wang, Chun-Hun Zhang, Bing-Lin Wang, Shuang Ma, Huan-Zhang Xie, Yu-Quan Wei, and Sheng-Yong Yang*. SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable 效價強度 in that of 化學標記語言 harboring 東南亞職業籃球聯賽 mutants. Leukemia, 2012. In press。
Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY*. Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3- Morpholinopropoxy) quinazolin-4-ylthio]-[1,3,4] thiadiazol-2-yl} -3-p-tolylurea and Its Anti-Acute Myeloid 白血病 (AML) Activities in Vitro and in vivo J Med Chem. 2012, 55, 3852-3866。
Youli pan, Yong Xu, Shan Feng, Shidong Luo, Renlin Zheng, Jiao Yang, Lijiao Wang, Lei Zhong, Han-Yu Yang, Bing-Lin Wang, Yang Yu, Jingjing Liu, Zhixing Cao, Xiaoyan Wang, Pan Ji, Zerong Wang, Xin Chen, Shuang Zhang, Yu-Quan Wei, and Sheng-Yong Yang*. SKLB1206, a Novel Orally Available Multikinase Inhibitor Targeting EGFR Activating and T790M Mutants, ErbB2, ErbB4, and VEGFR2, Displays Potent Antitumor Activity both In vitro and In vivo Mol Cancer Ther. 2012, 11(4), 952-962。
Wan HL, Wang ZR, Li LL, Cheng C, Ji P, Liu JJ, Zhang H, Zou J, Yang SY*.Discovery of novel Bruton's tyrosine kinase (Btk) inhibitors using a hybrid protocol of virtual screening approaches based on SVM model, pharmacophore, and molecular docking. Chem Biol Drug Des. 2012. doi: 10.1111/j.1747-0285 2012.01415.x。
Di-Wu L, Li LL, Wang WJ, Xie HZ, Yang J, Zhang CH, Huang Q, Zhong L, Feng S, Yang SY*。Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking. J 摩爾 Graph Model. 2012, 36, 42-47。
Xiao-Yu Qing, Chun-Hui Zhang, Lin-Li Li, pan Ji, Shuang Ma, Hua-Lin Wan, Ze-Rong Wang, Jun Zou, and Sheng-Yong Yang*. Retrieving Novel C5aR Antagonists using a Hybrid 配體based Virtual Screening Protocol based on SVM 分級 and Pharmacophore Models. J Biomol Struct Dyn. 2012, in press。
Zhong L, Ma CY, Zhang H, Yang LJ, Wan HL, Xie QQ, Li LL, Yang SY* A prediction model of substrates and non-substrates of breast cancer 厚膜電阻 proTEIN (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13。
Huang Q, Li LL, Yang SY*. RASA: a rapid retrosynthesis-based scoring method for the assessment of synthetic accessibility of drug-like molecules.J Chem Inf Model. 2011 Oct 24;51(10):2768-77。
Zhou JP, Chen X, Feng S, Luo SD, pan YL, Zhong L, Ji P, Wang ZR, Ma S, Li LL, Wei YQ, Yang SY* Systems Biology Modeling Reveals a Possible Mechanism of the Tumor 細胞 死亡 upon 癌基因 Inactivation in EGFR Addicted Cancers.PLoS One. 2011;6(12):e28930。
Ren JX, Li LL, Zheng RL, Xie HZ, Cao ZX, Feng S, pan YL, Chen X, Wei YQ, Yang SY* Discovery of novel Pim-1 kinase inhibitors by a hierarchical multistage virtual screening approach based on SVM model, pharmacophore, and molecular docking. J Chem Inf Model. 2011 Jun 27;51(6):1364-75。
Xie QQ, Zhong L, pan YL, Wang XY, Zhou JP, Di-Wu L, Huang Q, Wang YL, Yang LL, Xie HZ, Yang SY* Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met. Eur J Med Chem. 2011, 46, 3675-3680。
[12]Zhang H, Li W, Xie Y, Wang WJ, Li LL, Yang SY*. Rapid and accurate assessment of 癲癇發作 liability of drugs by using an optimal support 向量 machine method. Toxicol In Vitro. 2011,25,1848–1854。
Xie HZ, Liu LY, Ren JX, Zhou JP, Zheng RL, Li LL, Yang SY*. Pharmacophore modeling and hybrid virtual screening for the discovery of novel IκB kinase 2 (IKK2) inhibitors. J Biomol Struct Dyn. 2011, 29(1):165-79。
Dong X, Ebalunode JO, Yang SY, Zheng W. 捕手based pharmacophore and pharmacophore key descriptors for virtual screening and QSAR modeling. Curr Comput Aided Drug Des. 2011 Sep 1;7(3):181-9。
[15]Zeng XF, Li WW, Fan HJ, Wang XY, Ji P, Wang ZR, Ma S, Li LL, Ma XF, Yang SY* Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) 蛋白質結構域 Bioorg Med Chem Lett. 2011 Aug 15;21(16):4742-4。
Guo-Bo Li, Ling-Ling Yang, Shan Feng, Jian-Ping Zhou, Qi Huang, Huan-Zhang Xie, Lin-Li Li, Sheng-Yong Yang*. Discovery of novel mGluR1 antagonists: A multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor. Bioorg Med Chem Lett. 2011 Jan 25. [Epub ahead of print]。
Jun Zou,Shi-Dong Luo,Yu-Quan Wei and Sheng-Yong Yang*, Integrated computational model of cell cycle and checkpoint reveals different essential roles of 極光-A and Plk1 in mitotic entry. 摩爾 BioSyst., 2011, 7, 169–179。
Qi Huang, Lin-Li Li, Sheng-Yong Yang*. PhDD: A new pharmacophore-based de novo 設計 method of drug-like molecules combined with assessment of synthetic accessibility. Journal of Molecular Graphics and Modelling. 2010, 28, 775-787。
Wei-Wei Li, Jin-Juan Chen, Ren-Lin Zheng, Wen-Qin Zhang, 支姓 Cao, Ling-Ling Yang, Xiao-Yu Qing, Liang-Xue Zhou, Li Yang, Luo-Ding Yu, Li-Juan Chen, Yu-Quan Wei, and Sheng-Yong Yang*. Taking quinazoline as a general support-nog to 設計 potent and selective kinase inhibitors: application to FMS-like tyrosine 激酶 3. ChemMedChem. 2010, 5, 513-516。
Sheng-Yong Yang*. Pharmacophore modeling and applications in drug discovery: challenges and recent advances. Drug Discovery Today. 2010, 15, 444-450。
Li-Jun Yang, Jun Zou, Huan-Zhang Xie, Lin-Li Li, Yu-Quan Wei, Sheng-Yong Yang*. Steered molecular 動力學 simulations reveal the likelier dissociation 神經通路 of imatinib from its targeting kinases c-Kit and 東南亞職業籃球聯賽 PLOS One. 2009, 4, e8470。
Ji-Xia Ren, Lin-Li Li, Jun Zou, Li Yang, Jin-Liang Yang, Sheng-Yong Yang*. Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-b type I receptor (ALK5) inhibitors. European Journal of Medicinal 化學. 2009, 44, 4259-4265。
Huan-Zhang Xie, Lin-Li Li, Ji-Xia Ren, Jun Zou, Yu-Quan Wei, and Sheng-Yong Yang*. Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 1944-1949。
Jin-Juan Chen, Ting-Lin Liu, Li-Jun Yang, Lin-Li Li, Yu-Quan Wei and Sheng-Yong Yang*. Pharmacophore modeling and virtual screening studies of checkpoint kinase 1 inhibitors. Chem. Pharm. Bull. 2009, 57, 704-709。
Sheng-Yong Yang*, Qi Huang, Lin-Li Li, 常姓Ying Ma, Hui Zhang, Ru Bai, Qi-Zhi Teng, Ming-Li Xiang, Yu-Quan Wei. An integrated 概形 for feature selection and parameter setting in the support 向量 machine modeling and its application to the prediction of pharmacokinetic properties of drugs. Artificial Intelligence in Medicine. 2009, 46, 155-163。
Hui Zhang, Ming-Li Xiang, 常姓Ying Ma, Qi Huang, Wei Li, Yang Xie, Yu-Quan Wei, Sheng-Yong Yang*. Three-class 分級 models of logS and logP derived by using GA-CG-SVM approach. Molecular Diversity 2009, 13, 261-268。
Lijun Yang, Ruo Jia, Sheng-Yong Yang*. Influence of the solvent H?O molecules at the active site of CDK2 on the binding free 能量 of CDK2-配體 complexes: an MM/PBSA study. Acta Chimica Sinica. 2009, 67, 255-260。
Hui Zhang, Qing-Yi Chen, Ming-Li Xiang, 常姓Ying Ma, Qi Huang and Sheng-Yong Yang*. In silico prediction of mitochondrial 毒性 by using GA-CG-SVM approach. Toxicity in vitro, 2009, 23, 134–140。
Hui-Yuan Wang, Lin-Li Li, 支姓 Cao, Shi-Dong Luo, Yu-Quan Wei and Sheng-Yong Yang*. A specific pharmacophore model of Aurora B 激酶 inhibitors and virtual screening studies based on 信息技術 Chemical Biology & Drug 設計 2009, 73(1), 115-126。
Ting-lin Liu, Huan-zhang Xie, Yu-quan Wei, Sheng-Yong Yang*. Exploring the feasibility of application of reverse docking method to the selectivity studies of protein 激酶 inhibitors.Acta Pharmaceutica Sinica. 2009, 44(7), 758-763。
Qing-Qing Xie, Huan-Zhang Xie, Jie-Xia Ren, Lin-Li Li, and Sheng-Yong Yang*. Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2. Journal of Molecular Graphics and Modelling. 2009, 27, 751–758。
Hui Zhang, Ming-Li Xiang, Ying-Lan Zhao, Yu-Quan Wei and Sheng-Yong Yang*. Support vector machine and pharmacophore-based prediction models of multidrug-厚膜電阻 protein 2 (MRP2) inhibitors. European Journal of Pharmaceutical Sciences. 2009, 36, 451–457。
獲得榮譽
2023年8月31日，入選2023年中國科學院院士增選有效候選人名單。
參考資料 >
關于公布2023年中國科學院院士增選有效候選人名單的公告.中國科學院.2023-09-02