楊競，男，2015年入職北京大學生命科學學院助理教授，并受聘北京大學清華生命科學聯合中心和IDG麥戈文腦科學研究所研究員。他的研究領域主要集中在神經科學，特別是神經退行性疾病和代謝調控機制等前沿領域的基礎和應用研究。楊競教授已在《細胞》(細胞)、《神經元》(Neuron)等國際著名學術期刊上發表論文十余篇，并在2015年獲得國家中華人民共和國國家自然科學基金委員會“優秀青年科學基金”。
個人經歷
楊競教授于2003年在趙進東院士的指導下，于北京大學生命科學學院獲得生物科學學士。隨后，他在美國得克薩斯大學西南醫學中心師從諾貝爾獎得主Michael Brown和Joseph Goldstein，于2009年獲得生物醫學博士學位。在獲得博士學位后，楊競教授在美國基因泰克公司和洛克菲勒大學從事博士后研究，直至2015年加入北京大學生命科學學院。在學術成就方面，楊競教授曾獲得Tri-Institutional Breakout Prize、“求是”杰出青年學者獎等多項學術獎項。
研究領域
楊競教授的研究領域涉及神經科學，特別是神經退行性疾病和代謝調控機制。他的工作揭示了神經系統和免疫系統之間密不可分的聯系，特別是在神經系統調節多種器官和組織內免疫反應的重要功能方面。這一領域的研究為生物醫學研究提供了新的視角，并為治療不同免疫相關疾病提供了潛在的治療策略。
學術成就
楊競教授在神經生物學領域的研究成果獲得了廣泛認可。他在2016年獲得“求是杰出青年學者獎”，該獎項是通過求是基金會嚴格的同行評議和專家委員會評審后授予的。此外，他還曾獲得國家中華人民共和國國家自然科學基金委員會“優秀青年科學基金”以及其他學術獎項，以表彰他在科研領域的卓越貢獻。
主要論文
Publications since the current position:
1. Representative Publications (# corresponding author):
(1) Xu Q, Cao Y, Kong F, Liu J, Chen X, Zhao Y, Lai CH, Zhou X, Hu H, Fu W, Chen J, Yang J#. 倍數 Cancer 細胞 Types Release LIF and Gal3 to Hijack Neural Signals. Cell Research. 2024 May;34(5):345-354.
(2) Gong X, Chong K, Liu J, 成姓 W, Yang J#, Liu B#. AIENP-Reinforced 迪斯科 Method for Whole-Tissue Three-Dimensional Reconstruction of Pulmonary Capillaries. Advanced Functional Materials. 2024 Mar;34(13):2312176.
(3) Zhang M, Liu T, Yang J#. Skin neuropathy and immunomodulation in diseases. Fundamental Research. 2024 Mar;4(2):218-225.
(4) Liu J, Li Z, Li M, Du W, Baumeister W, Yang J#, Guo Q#. Vimentin regulates NU.CLEAR segmentation in neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 2023 Nov 28;120(48):e2307389120.
(5) Liu T, Liu J, Chen H, Zhou X, Fu W, Cao Y, Yang J#. Cannabinoid 捕手 2 signal promotes type 2 immunity in the lung. 細胞 Insight. 2023 Oct 6;2(5):100124.
(6) Cao Y, Chen H, Yang J#. Neuroanatomy of lymphoid organs: Lessons learned from whole‐tissue imaging studies. European Journal of Immunology. 2023 Oct;53(10):e2250136.
(7) Cao Y, Liu T, Zhou X, Fu W, Li J, Yang J#. 3D anatomy of autonomic innervations in immune organs of a non-human 靈長目 and the human. Fundamental Research. 2023 Mar;3(2):249-256.
(8) Yang J#, Yaron A, Liu K. Editorial: Neuroimmune interactions in peripheral neuropathy. Frontiers in Molecular 神經科學 2022 May;15:929081.
(9) Liu C, Yang J#. Enteric glial cells in immunological disorders of the gut. Frontiers in Cellular Neuroscience. 2022 Apr;16:895871.
(10) Cao Y, Wang Y, Yang J#. NAD+-dependent mechanism of pathological axon degeneration. 細胞 Insight. 2022 Mar 4;1(2):100019.
(11) Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J#. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon. Protein 細胞 2021 Aug;12(8):621-638.
(12) Liu K, Yang L, Wang G, Liu J, Zhao X, Wang Y, Li J, Yang J#. Metabolic 應力 drives sympathetic neuropathy within the liver. Cell 新陳代謝 2021 Mar 2;33(3):666-675.e4.
(13) Jiang Y, Liu T, Lee CH, Chang Q, Yang J#, Zhang Z#. The NAD(+)-mediated self-inhibition mechanism of proneurodegenerative SARM1. Nature. 2020 Dec;588(7839):658-663.
(14) Liu T, Yang L, Han X, Ding X, Li J, Yang J#. Local sympathetic innervations modulate the lung innate immune responses. Science Advances. 2020 May 13;6(20):eaay1497.
(15) Wang Q, Liu K, Yang L, Wang H, Yang J#. BoneClear: whole-tissue immunolabeling of the intact mouse bones for 3D imaging of neural anatomy and pathology. Cell Research. 2019 Oct;29(10):870-872.
(16) Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, Yang J#. 復總狀花序Shaped Sympathetic 建筑 in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Reports. 2019 Jun 25;27(13):3799-3807.e3.
(17) Zhou N, Liu K, Sun Y, Cao Y, Yang J#. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein 細胞 2019 Feb;10(2):87-103.
(18) Zhou N, Yang J#. Molecular Mechanism of Wallerian Degeneration. Chinese Bulletin of Life Sciences. 2017 Mar; 29(3): 245-250.
2. Additional Publications:
(1) Liu T, Wang H, Kutsovsky DY, Iskols M, Chen H, Ohn CYJ, Patel N, Yang J, Simon DJ. An axon-T 細胞 feedback loop enhances inflammation and axon degeneration. Cell Reports. 2024 Feb 27;43(2):113721.
(2) Yang L, Wang X, Yu XX, Yang L, Zhou BC, Yang J, Xu 鉻 The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms. Developmental 細胞 2023 Sep 25;58(18):1688-1700.e6.
(3) Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z. Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell 探索頻道 2022 Dec 28;8(1):141.
(4) Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z. Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8. Nature Communications. 2022 Aug 25;13(1):4988.
(5) Hu H, Cui YW, Yang J, Cao Y. Loss of the sympathetic signal produces sterile inflammation of the prostate. Frontiers in Molecular 神經科學 2022 May;15:855376.
(6) Li X, Qi L, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H, Wei B. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nature 神經科學 2022 May;25(5):577-587.
(7) Qian K, Liu J, Cao Y, Yang J, 裘姓 S. Intraperitoneal injection of 鋰 氯代十六烷 induces lateralized activation of the insular cortex in adult mice. Molecular Brain. 2021 Apr 19;14(1):71.
(8) Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K(+) channel regulates Parkinson`s 病理學 Nature. 2021 Mar;591(7850):431-437.
(9) Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in ε-Sarcoglycan Induces a Myoclonus-肌張力障礙 綜合征Like Movement Disorder in 鼠科 神經科學 Bulletin. 2021 Mar;37(3):311-322.
(10) Simon DJ, Pitts J, 赫茲 NT, Yang J, Yamagishi Y, Olsen O, Te?i? Mark M, Molina H, Tessier-Lavigne M. Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling. 細胞 2016 Feb 25;164(5):1031-45.
3. Book Chapters:
(1) Cao Y, Yang J. Mechanisms of Pathological Axonal Degeneration. In: Tran SS501 and Yaron A.(eds) Wiring the Nervous System, 2024 Jan;215-250. River Publishers, Gistrup, Denmark.
(2) Cao Y, Yang J. Whole-Tissue Immunolabeling and 3D 熒光 Imaging to Visualize Axon Degeneration in the Intact, Unsectioned Mouse Tissues. In: Babetto E.(eds) Methods in Molecular Biology, 2020 Jun 11;2143:223-232. Humana, New York, NY.
(3) Wang F, Yang J, He Z. Axon maintenance and degeneration. In: Rubenstein J., Rakic P., Chen B., Kwan K.Y., Kolodkin A., and Anton E.(eds) Comprehensive Developmental 神經科學 (2nd Edition), 2020 Jun 5;217-230. Academic Press, Cambridge, MA.
Publications before the current position:
(1) Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal 死亡 through a MAPK cascade that triggers a local 能量 deficit. 細胞 2015 Jan 15;160(1-2):161-76.
(2) Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.
(3) Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M. Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89. (* contributed equally)
(4) Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5;110(10):4039-44.
(5) Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O`Leary DD, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. Journal of 神經科學 2012 Dec 5;32(49):17540-53.
(6) Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR. dSarm/Sarm1 is required for activation of an injury-induced axon 死亡 pathway. Science. 2012 Jul 27;337(6093):481-4.
(7) Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman Jackie McLean Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. American Journal of Physiology-Endocrinology and 新陳代謝 2009 Jul;297(1):E134-41. (* contributed equally)
(8) Yang J*, Zhao TJ*, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 5;105(31):10750-5. (* contributed equally)
(9) Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. 細胞 2008 Feb 8;132(3):387-96.
(10) Yang J, Dong C, Huang X, Zhao J. Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from 脫氧核糖核酸 digestion solutions. Analytical Biochemistry. 2003 Nov 1;322(1):99-103.
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楊競.北京大學生命科學學院.2024-09-09