周如鴻，男，舟山定海人，1984年畢業(yè)于浙江省舟山中學(xué)，1990年周如鴻獲浙江大學(xué)凝聚態(tài)物理碩士學(xué)位，后留校任教，1997年獲美國哥倫比亞大學(xué)博士學(xué)位。曾任IBM Watson 研究院軟物質(zhì)科學(xué)實(shí)驗(yàn)室主任， IBM藍(lán)色基因計(jì)劃生命科學(xué)首席科學(xué)家，哥倫比亞大學(xué)化學(xué)系兼職教授，美國科學(xué)促進(jìn)會(huì)院士?，F(xiàn)任浙江大學(xué)生命科學(xué)學(xué)院院長、浙江大學(xué)上海高等研究院院長、定量生物中心主任、求是講席教授。
人物經(jīng)歷
教育經(jīng)歷
工作經(jīng)歷
周如鴻教授于2011年當(dāng)選美國科學(xué)促進(jìn)會(huì)會(huì)士(美國藝術(shù)與科學(xué)院 Fellow)，美國物理學(xué)會(huì)會(huì)士(APS Fellow)，并于2012年入選IBM全球八大研究院“將對(duì)IBM，對(duì)世界，可能產(chǎn)生最重大影響”的五名科學(xué)家之一。周如鴻教授同時(shí)擔(dān)任美國分子科學(xué)領(lǐng)域頂尖的Telluride科學(xué)研究中心董事會(huì)的董事（Board of Directors），和芝加哥大學(xué)多尺度科學(xué)中心的科學(xué)顧問（Scientific Advisory Board）。
現(xiàn)任浙江大學(xué)求是講席教授，生命科學(xué)院院長，上海高等研究院院長，科技部十四五“生物大分子與微生物”專家組成員，哥倫比亞大學(xué)化學(xué)系兼職教授。曾任IBM Watson 研究院軟物質(zhì)科學(xué)系主任，IBM藍(lán)色基因計(jì)劃生命科學(xué)首席科學(xué)家，杰出研究員。
在分子動(dòng)力學(xué)模擬蛋白質(zhì)結(jié)構(gòu)，功能，以及動(dòng)態(tài)過程、納米尺度水的生物效應(yīng)、以及納米顆粒與生物分子的相互作用等研究領(lǐng)域成就顯著。擁有或已申請(qǐng)14項(xiàng)美國專利。在權(quán)威學(xué)術(shù)刊物發(fā)表學(xué)術(shù)論文102篇，SCI引用3200余次。應(yīng)邀在世界各地大學(xué)、研究機(jī)構(gòu)和國際學(xué)術(shù)會(huì)議上做邀請(qǐng)報(bào)120余次，是期刊《Nanoscale》、《Current Physical Chemistry》客座主編，也是 《Current Bioinformatics》等6家國際期刊的編委。
代表論文
1. R. H. Zhou, X. Huang, C. Margulius and B. J. Berne, Hydrophobic Collapse in Multi-domain Protein Folding, Science, 305, 1605-1609, 2004
2. P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005
3. L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE 脫氧核糖核酸 Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012
4. Z. Xia, P. Clark, T. Huynh, P. Loher, Y. Zhao, H.W. Chen, P. Y. Ren, I. Rigoutsos, and R. H. Zhou, Molecular 動(dòng)力學(xué) simulations of Ago silencing complexes reveal a large repertoire of admissible ‘seed-less’ targets, Scientific Reports, 2, 569, 2012
5. S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo 設(shè)計(jì) of Nanomedicine, Proc. Natl. Acad. Sci., 109, in press, 2012
6. C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall 碳 nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)
7. P. Das, J. A. King, and R. H. Zhou, Aggregation of ?D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal ?-strands, P世界車王爭霸賽 Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)
8. Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, H?Omediated signal multiplication with Y-shaped 碳 nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009
9. L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, 尿素 denaturation by stronger dispersion interactions with proteins than H?O implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008
10. J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007
11. R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007
12. R. H. Zhou, Trp-cage: Folding Free 能量 Landscape in Explicit H?O, Proc. Natl. Acad. Sci., 100, 13280， -13285, 2003
13. R. H. Zhou and B. D. Silverman, Detecting native protein folds among large decoy sets with hydrophobic moments profiling, Proc. Paci. Symp. Biocomp. 2002, Eds. R. B. Altman, A. K. Dunker, L. Hunter, K. Lauderdale and T. E. Klein, p673-684, World Scientific, Singapore, 2002
14. R. H. Zhou, B. J. Berne and R. Germain, Free 能量 landscape of a beta-hairpin folding in explicit H?O, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001
獲獎(jiǎng)情況
1. CAREER Award for Researchers “most likely to have the greatest scientific impact for IBM and the world” (at most five scientists chosen each year among eight IBM labs worldwide), IBM Research, May, 2012
2. IBM Outstanding Innovation Award (OIA), IBM Corp. 2012
3. IBM Research Division Award, IBM Research (2012)
4. William E. Schiesser Lecture, Lehigh University, April 2012
5. Elected to AAAS Fellow (American Association of Advancement of Science), 2011
6. Elected to APS Fellow (American Physical Society), 2011
7. Part of the IBM BlueGene Team who won 2009 National Medal on Innovation and Technology (presented by President Obama), 2009
8. IBM Invention Plateau Achievement Award, IBM Corporation (2009)
9. IBM Outstanding Technical Achievement Award (OTAA, the highest technical award of IBM), IBM Corp. (2008)
10. IBM Outstanding 松香酸 Achievement Award (OTAA), IBM Corp. (2005)
11. IBM Research Division Award, IBM Research (2005)
12. IBM Invention Plateau Achievement Award, IBM Corporation (2004)
13. IBM Invention Achievement Award, IBM Corporation (2002)
14. The Hammett Award for Best Ph.D. Graduates, Columbia University (1997)
15. ACS Award on Computational 化學(xué) (DEC Award), American Chemical Society (1995)
16. Faculty Fellowship, Columbia University (1994-1997)
17. Second Prize, Research in Science & Technology, China Ministry of Education (1993)
18. Best Paper Award for Outstanding Research, Zhejiang University (1993)
19. Award for Outstanding Research, Zhejiang University (1992)
知識(shí)產(chǎn)權(quán)
1. Bruce J. Berne and Ruhong Zhou, Fast methods for simulating biomolecular systems with long-range electrostatic interactions by molecular 動(dòng)力學(xué), US patent No. 5,915,230, Jun 22, 1999
2. Ruhong Zhou, Huafeng Xu, Ed Harder, and Bruce J. Berne, System and Method for Molecular Dynamics Simulation , US patent, No. 7,096,167 B2, August 22, 2006
3. Prasanna Athma, Ajay Royyuru, David Silverman and Ruhong Zhou, Method and apparatus for protein structure analysis, US Patent, No. 7,499,805, March 3, 2009
4. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Moment of Multi-domain Proteins, United States, US patent No. 7,877,214, Jan, 25, 2011
5. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Dipole Orientational Analysis for Multi-domain Protein Structures, US patent No. 8,010,332, Jan, 2012
6. Ruhong Zhou, and David Silverman, Method and Apparatus for Protein Structure Analysis, US patent filed (IBM Docket No. YOR920020224US1), Nov. 15, 2002
7. David Silverman, Ruhong Zhou and Ajay Royyuru, Hydrophobic Fourier Transform for Protein Structure Prediction Validation, US patent search (IBM Docket No. YOR820030692), September, 2003
8. Laxmi Parida and Ruhong Zhou, Pattern Discovery Analysis for Protein Folding Trajectories, US patent search (IBM Docket No. YOR820040227), April, 2004
9. Laxmi Parida and Ruhong Zhou, Clustering of Multidimentional Real-valued 數(shù)據(jù) Using Signature Patterns, US patent (IBM Docket No. YOR820040321), May, 2004
10. Laxmi Parida and Ruhong Zhou, Visual Analysis of Pattern Landscape 動(dòng)畫, US patent (IBM Docket No. YOR920060233US1), March, 2006
11. Zhen Xia and Ruhong Zhou, Prediction of Influenza A Virus' Genetic Evolution with a Mutual Information Based Site Transition Network, IBM Docket No. YOR820090279, July 1, 2009
12. Payel Das and Ruhong Zhou, A biomimetic nano-pump for automatic separation of urea from H?O, 解密兄弟 NO. YOR820101155, November 12, 2010
13. Zhen Xia, Tien Hyunh, and Ruhong Zhou, Weighted mutual information method and automatic web server for 流行性感冒 genetic variation prediction, DISCLOSURE NO. YOR820101065, October 18, 2010
14. James Kozloski, Cliff Pickover, Jacinta Wubben and Ruhong Zhou, System and Method for Competitive Binding of Sequence Annotations and Analysis Tools to Sequences in a Biological 數(shù)據(jù) Repository, YOR820110975, October, 2011
15. Binquan Luan and Ruhong Zhou, Base-by-base Ratcheting 脫氧核糖核酸 in a Y-shaped 碳 Nanotube, YOR820120589, May, 2012
16. Binquan Luan and Ruhong Zhou, Nanopore-Based Sensors for Detecting Nanotoxicity of a Carbon Nanotube to Proteins, YOR820120951, July, 2012
參考資料 >
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