陳實，教授，博士生導師，美國微生物科學院Fellow、國家基金委杰出青年基金獲得者。
獲獎情況
2004年明治乳業生命科學優秀獎
2004年上海-聯合利華公司研究與發展基金獎學金
2004年上海市新長征突擊手“標兵”
2004年新加坡陳嘉庚基金會第二屆陳嘉庚青少年發明獎（上海）（銀獎）
2006年上海市研究生學位論文優秀成果
2007年《環球科學》2007年度全球十大科學新聞
2007年上海市優秀發明獎選拔賽二等獎
2007年新加坡陳嘉庚基金會第五屆陳嘉庚青少年發明獎（上海）（銅獎）
2008年國家自然科學獎二等獎
2008年新加坡陳嘉庚基金會第六屆陳嘉庚青少年發明獎（上海市）（銅獎）
2012年武漢大學醫學部醫學突出貢獻獎
2014年中國微生物學會學術年會優秀學術論文獎
2015年高等學校科學研究優秀成果獎自然科學一等獎
2015年武漢大學醫學部醫學突出貢獻獎
2016年中國微生物學會學術年會優秀學術論文獎
2017年湖北省醫學領軍人才
2017年武漢大學杰出青年（教職工）
2018年武漢大學朱裕璧醫學獎
2019年國家基金委杰出青年基金
2020年美國微生物科學院Fellow (Fellow of American Academy of Microbiology)
研究方向
1．基因組修飾及編輯
2．脫氧核糖核酸骨架的磷硫化生理修飾
3．創新藥物的設計與改造
學術論文
1.Chen C, Wang L, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114.
2.Tong T#, Chen S#, Wang L#, Tang Y#, Ryu JY, Jiang S, Wu X, Chao Chen C, Luo J, Deng Z, Li Z, Lee SY*, Shi Chen*. Occurrence, evolution, and 函數s of 脫氧核糖核酸 phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, doi:10.1073/pnas.1721916115.
3.Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of 脫氧核糖核酸 phosphorothioation-based antiviral system in 古菌 Nature Communications, 2019, Apr 11;10(1):1688. doi: 10.1038/s41467-019-09390-9.
4.Cao B. #, Chen C. #, DeMott 多發性硬化癥 #, Cheng Q., Clark T.A., Xiong X., Zheng X., Butty V., Levine S.S., Yuan G., Boitano M., Luong K., Song Y., Zhou X., Deng Z., Turner S.W., Korlach J., You D.*, Wang L.*, Chen S.*, Dedon P.C. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, doi:10.1038/ncomms4951.
5.Wang L, Chen S*, Vergin KL, Giovannoni SJ, Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC*. 脫氧核糖核酸 phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968.
6.Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S*. Synthetic genomes: from 脫氧核糖核酸 synthesis to genome 設計 Angew Chemie Int Ed., 2018, 57: 2~11.
7.Wang L, Jiang S, Deng Z, Dedon P, Chen S*. DNA phosphorothioate modification – a new multi- functional epigenetic system in bacteria. FEMS Microbiology Reviews, 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036
8. Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S*, Yue Z*. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy, 2019 Jul 30:1-15. doi: 10.1080/15548627.2019.1644076.
9. Chen Y., Deng Z, Jiang S., Hu Q., Liu H., Zhou S., Ma W., Chen S.*, Zhao Y*. Human cells lacking coilin and Cajal bodies areproficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11, doi: 10.1093/nar/gku1277.
10. Zou X#, Wang L#, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260.
11. Wang F#, Wang L#, Zou X., Duan S., Li Z., Deng Z., Luo J., Lee S. Y.*, Chen S*. Advances in CRISPR-Cas systems for 核糖核酸 targeting, tracking and editing. Biotechnology Advances, 2019, https://doi.org/10.1016/j.biotechadv.2019.03.016.
12. Deng Z, Purtell K Lachance V, Wold M, Chen S*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. doi.org/10.1016/j.tcb.2017.01.001.
13. Wu S#, Wang L# ; Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S*. Signature 砷 detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018, May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18.
14. Xia S, Chen J, Liu L, Wei Y, Deng Z, Wang L, Chen S*. Tight control of genomic phosphorothioate modification by the 巴西網球公開賽modulated autoregulation and reusability of DndB. Molecular Microbiology, 2019 April, 11(4): 938-950. doi: 10.1111/mmi.14186.
15. Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Chen S*, Zhao X*. Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity. Theranostics, 2018, 8(6): 1624~1635
16. Liu L, Zhang Y, Jiang D, Du S, Deng Z, Wang L, and Chen S*. Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications. Biotechnology Journal, 2019, 14, 1800001. DOI: 10.1002/biot.201800001.
17.Yan G, Chen X, Du S, Deng Z, Wang L, Chen S*. Genetic mechanisms of 砷 detoxification and
新陳代謝 in bacteria. Current Genetics, 2019, 65: 329–338, doi.org/10.1007/s00294-018-0894-9.
18. Chen S.*, Wang L., Deng Z*. Twenty years hunting for 硫 in 脫氧核糖核酸 Protein & Cell, 2010, 1(1): 14-21.
19. Wang L.#, Chen S.#, Xu T., Taghizadeh K., Wishnok J., Zhou X., You D., Deng Z, Dedon P. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology, 2007, 3(11): 709-710.
20. Chen S.#, Galan M. C.#, Carla Coltharp, O’Connor S. E. Redesign of a central enzyme in alkaloid biosynthesis. 化學 & Biology, 2006, 13(11): 1137-41.
21. Chen S, Huang X, Zhou X, Bai L, He J, Jeong KJ, Lee SY, Deng Z. Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. 化學 & Biology, 2003, 10(11): 1065-76.
22. Chen S.#, Mao X.#, Shen Y., Zhou Y., Li J., Wang L., Tao X., Yang L., Wang Y., Zhou X., Deng Z., Wei D. Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. Applied and Environmental Microbiology, 2009, 75(6): 1778-81.
參考資料 >
陳實.武漢大學藥學院.2022-03-09