楊力，1998年7月本科畢業(yè)于蘭州大學(xué)，2004年3月于中科院中國科學(xué)院上海生命科學(xué)研究院生物化學(xué)與細(xì)胞生物學(xué)研究所獲博士學(xué)位。
現(xiàn)任復(fù)旦大學(xué)生物醫(yī)學(xué)研究院研究員。
個人資料
楊力于1998年本科畢業(yè)于蘭州大學(xué)生物化學(xué)與分子生物學(xué)專業(yè)。畢業(yè)后前往中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所攻讀博士學(xué)位。2004年博士畢業(yè)后師從于1989年諾貝爾化學(xué)獎SidneyAltman，在耶魯大學(xué)進(jìn)行博士后工作。2007年在康涅狄格大學(xué)Brenton R. Graveley實(shí)驗(yàn)室繼續(xù)博士后工作。
2010年10月，楊力回國，獲任中國科學(xué)院上海生命科學(xué)研究院科研處處長，次年7月任中科院-德國馬普學(xué)會計算生物學(xué)伙伴研究所/上海營養(yǎng)與健康研究所研究員。
2022年2月起任復(fù)旦大學(xué)生物醫(yī)學(xué)研究院研究員。
工作經(jīng)歷
08/2011-date: Principle Investigator, Professor, Chinese Academy of Sciences - Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
10/2010-07/2011: Director, Professor, Department of Scientific Research Management, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
01/2007-09/2010: Postdoctoral Fellow with Dr. Brenton R. Graveley, University of Connecticut Health Center, Farmington, CT 06030, USA.
08/2004-12/2006: Postdoctoral Associate with Dr. Sidney Altman (Nobel Laureate in 化學(xué), 1989), 耶魯大學(xué) University, New Haven, CT 06520, 南阿拉巴馬大學(xué)
09/1998-07/2004: Ph.D. student and research assistant with Dr. Bo-Liang Li, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
研究方向
從1990年開始到2001年第一個人類全基因組測序結(jié)果發(fā)表，人類基因組計劃僅耗材花費(fèi)就高達(dá)30億美元。利用新一代高通量測序技術(shù)，基因組測序的時間和耗費(fèi)被極大地降低了，這使得高通量測序技術(shù)被廣泛的應(yīng)用于生命科學(xué)研究的各個領(lǐng)域中，極大的促進(jìn)了現(xiàn)代生命科學(xué)的發(fā)展。楊力實(shí)驗(yàn)室利用高通量測序技術(shù)和相應(yīng)的計算生物學(xué)分析方法，對真核生物核糖核酸的表達(dá)調(diào)控在全轉(zhuǎn)錄組水平進(jìn)行系統(tǒng)檢測，主要圍繞模式生物果蠅和人源胚胎干細(xì)胞及其定向分化的RNA選擇性剪接和非編碼RNA功能作用進(jìn)行研究，并系統(tǒng)解析RNA的復(fù)雜調(diào)控網(wǎng)絡(luò)。實(shí)驗(yàn)室將利用實(shí)驗(yàn)（包括新一代高通量測序，分子和細(xì)胞生物學(xué)等）和計算（包括統(tǒng)計，生物信息學(xué)等）生物學(xué)的方法進(jìn)行系統(tǒng)研究，以期拓展人類在全轉(zhuǎn)錄組水平對RNA重要生理功能及其調(diào)控作用的全面認(rèn)識。
代表性論文
2015:
Angela N Brooks*, Michael O Duff, Gemma May, Li Yang, Mohan Bolisetty, Jane Landolin, Ken Wan, Jeremy Sandler, Susan E Celniker, Brenton R Graveley# and Steven E Brenner#. Genome Res 2015, doi: 10.1101/gr.192518.115
Jian-Feng Xiang, Li Yang, Ling-Ling Chen#. The long noncoding 核糖核酸 regulation at the MYC locus. Curr Opin Genet Dev 2015, 33:41–48
Cuiqing Zhong*, Qi Yin*, Zhenfei Xie*, Meizhu Bai*, Rui 越南盾*, Wei Tang, Yu-Hang Xing, Hongling Zhang, Suming Yang, Ling-Ling Chen, Marisa S. Bartolomei, Anne Ferguson-Smith, Dangsheng Li, Li Yang#, Yuxuan Wu# and Jinsong Li#. CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide 核糖核酸 Library. Cell Stem Cell, 2015, 17: 1-12
Chen LL# and Yang L#. Gear up in circles. 摩爾 Cell, 2015, 58:715-717 (Preview)
Hu SB, Xiang JF, Li X, Xu Y, Xue W, Huang M, Wong CC, Sagum CA, Bedford MT, Yang L, Cheng D, and Chen LL. Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus. Genes & Dev, 2015, 29: 630-645
Ling-Ling Chen# and Li Yang#. Regulation of circRNA biogenesis. RNA Biology, 2015, 12: 381-388
Chen T*, Xiang JF*, Zhu S*, Chen S, Yin QF, Zhang XO, Zhang J, Feng H, 越南盾 R, Li XJ, Yang L# and Chen LL#. 2015. ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner. Cell Res, 2015, 25: 459-476
Yin QF*, Hu SB*, Xu YF, Yang L, Carmichael GG and Chen LL. SnoVectors for nuclear expression of 核糖核酸 Nucleic Acids Res, 2015, 43: e5
Wang D*, Cai C*, Dong X, Yu QC, Zhang XO, Yang L, Zeng YA. Identification of multipotent mammary stem cells by protein C receptor expression. Nature, 2015, 517:81-84
Yin QF, Chen LL# and Yang L#. Fractionation of Non-polyadenylated and Ribosomal-free RNAs from Mammalian Cells. Methods 摩爾 Biol, 2015, 1206: 69-80 (Book chapter)
2014:
Yang L# and 金鐘大 LL#. Microexons go big. Cell, 2014, 159: 1488-1489 (Invited preview)
Yang L# and Chen LL#. Competition of 核糖核酸 splicing: line in or circle up. Sci China Life Sci, 2014, 57: 1232-1233 (Invited review)
Dong R, Chen LL and Yang L. Research progress of circular RNA in the post-genome era. Chinese J Cell Biol, 2014, 36: 1455-1459 (Invited review, in Chinese)
Zhang XO*, Wang HB*, Zhang Y, Lu X, Chen LL# and Yang L#. Complementary sequence-mediated exon circularization. Cell, 2014, 159: 134-147 (Issue Highlight)
Editorial by: Vicens Q and Westhof E. Cell, 2014, 159: 13-14
Highlighed by: Nat Rev Genet, 2014, 15: 707
Gerstein M*, Rozowsky J*, Yan KK*, Wang D*, Cheng C*, 褐色 JB*, Davis C*, Hillier L*, Sisu C*, Li JJ*, Pei B*, Harmanci AO*, Duff MO*, Djebali S*, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boech ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigo R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJP, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders G, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE#, Graveley BR#, Celniker SE#, Gingeras TR# and Waterston R#. Comparative analysis of the transcriptome across distant 物種 Nature, 2014, 512: 445-448
Zhang Y, Yang L and Chen LL. Life without A tail: new formats of long noncoding RNAs. Int J Biochem and Cell Biol, 2014, 54: 338-349 (Invited review)
Zhang XO, Yin QF, Chen LL and Yang L. Gene expression profiling of non-polyadenylated 核糖核酸-seq across 物種 Genomics Data, 2014, 2:237-241
Zhang XO*, Yin QF*, Wang HB, Zhang Y, Chen T, Zheng P, Lu X, Chen LL# and Yang L#. Species-specific alternative splicing leads to unique expression of sno-lncRNAs. BMC Genomics, 2014, 15: 287 (Highly Accessed)
Editorial by: BioMed Central portal-Biome on 17th April 2014: sno-lncRNAs: a story of splicing across humans, rhesus and mice (http://www.biomedcentral.com/biome/sno-lncrnas-a-story-of-splicing-across humans-rhesus-and-mice/)
Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO,Wu Z, Zhang S, Wang HB, Ge JH, Lu XH, Yang L and Chen LL. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions in the MYC locus. Cell Res, 2014, 24:513-531 (Cover Article and Issue Highlight)
Editorial by: Younger ST and Rinn JL. Cell Res, 2014, 48:155-157
Highlighted by: Nature.com
Highlighted by: Global Medical Discovery
Highlighted by: National Science Reviews
2013:
Zhang Y*, Zhang XO*, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L# and Chen LL#. Circular intronic long noncoding RNAs. 摩爾 Cell, 2013, 51: 792-806 (Issue Highlight)
Editorial by: Bolisetty MT and Graveley BR. Mol Cell, 2013, 51:705-706
Editorial by: Reid T. Nature China, 2013, Epub. on Oct. 2nd (doi:10.1038)
Editorial by: Tomkins J. Institute for Creation Res, 2013, Epub. on Oct. 9th
Research Highlight by: Nature, 2013, 501:464
Zhu S*, Xiang JF*, Tian C, Chen LL# and Yang L#. Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences. BMC Genomics, 2013,14: 206 (Highly Accessed)
Zhu S, Zhang XO and Yang L. Panning for long noncoding RNAs. Biomolecules, 2013, 3: 226-241 (Invited review)
Yang L, Wei G, Tang K, Nardini C and Han JD. Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures. Sci China Life Sci, 2013, 56: 213-219 (Invited review)
2012:
Bass B, Hundley H, Li JB, Peng Z, Pickrell J, Xiao XG and Yang L. The difficult calls in RNA editing. Nat Biotechnol, 2012, 30: 1207-1209 (Invited review)
Yin QF*, Yang L*, Zhang Y, Xiang JF, Wu YW, Carmichael GG# and Chen LL#. Long noncoding RNAs with snoRNA ends. 摩爾 Cell, 2012, 48: 219-230 (Cover Article and Issue Highlight)
Editorial by: McCann KL and Baserga SJ. Mol Cell, 2013, 48:155-157
Editorial by: David R. Nat Rev Mol Cell Biol, 2012, 13:686
News coverage by: Foundation for Prader-Willi Research
Recommended by: 5 articles in F1000 Prime
Best of Molecular Cell 2012
參考資料 >
中科院“杰青”楊力已加盟復(fù)旦大學(xué)生物醫(yī)學(xué)研究院.澎湃新聞.2022-02-14
Publications.Eukaryotic Transcriptomics (Yang Lab).2015-08-26