郭麗，女，畢業于四川醫學院，德國Tuebingen大學有機化學研究所，博士后，現為四川大學華西藥學院教授、博士生導師，華西藥學院藥物化學系主任。兼任四川省學術和技術帶頭人后備人選，四川省衛生廳學術和技術帶頭人，四川省新藥評審委員、四川省科技計劃項目評審專家。
研究方向：靶向藥物及聚集型多肽藥物的研究，樹枝狀化合物在藥物研究中的應用，主要研究課題及成果有“新型多分枝狀肽大分子的合成及初步生物活性的研究”等3項，代表論著有微波輔助合成羅庫溴銨重要中間體等25項。
人物經歷
教育經歷
工作經歷
1995年在四川大學化工學院晉升副教授。
2000年～2001年德國Tuebingen大學有機化學研究所,博士后工作。
2003年在四川大學華西藥學院晉升教授,2004年聘為博士生導師。
2007～至今華西藥學院藥物化學系主任。
獲得榮譽
先后獲四川大學校級教學成果獎、卓越教學獎、優秀教師稱號，連續多年獲得校級及學院優秀教學獎勵。
研究方向
1．靶向藥物及聚集型多肽藥物的研究。
2．樹枝狀化合物在藥物研究中的應用。
社會任職
四川省學術和技術帶頭人后備人選，四川省衛生廳學術和技術帶頭人，四川大學教學名師培養對象。國家科技獎勵評審專家，國家自然科學基金同行評審專家等。
主要成就
科研成就
先后負責國家自然科學基金項目2項，教育部歸國人員科研啟動基金項目1項，校級基金項目2項以及企業合作項目。主持多項國家級、省級以及校級教改項目。
研究成果
1.教育部留學回國人員啟動基金項目“新型分子酶大分子的合成及初步生物活性的研究”、2003-2004,項目負責人；
2.國家自然科學基金項目“新型樹狀多聚活性肽化合物的合成及初步生物活性的研究”、2005-2007,項目負責人
3.四川大學振興計劃引進人才基金“酶法多肽及樹狀化合物合成研究”,2002-,項目負責人。
人才培養
已培養碩士及博士生研究生40余人。
個人作品
發表論文
（2012～）在國內外核心期刊上發表科研論文90多篇。
1.Novel Dendritic 萘普生 Prodrugs with Poly(aspartic acid) Oligopeptide: Synthesis and 羥基磷灰石 Binding In Vitro,Synthetic Communications,2012,42,3441-3451
2.Synthesis and preliminary evaluation of novel amphiphilic Janus dendrimers for bone-targeted drug delivery，Tetrahedron,2012,68,2943-2949
3.Synthesis, antibacterial activity and cytotoxicity of novel Janus peptide dendrimers,?synlett，2012, 23,1937-1940
4.Dual-targeting delivery system for bone cancer: synthesis and preliminary biological evaluation,?Drug Delivery，2012,19(7),317-326
5.Design and synthesis of novel Janus dendrimers as lipophilized antioxidants，synlett.?2013,24(8), 1011-1015
6.Dual-targeting Janus dendrimer based peptides for bone cancer: synthesis and preliminary biological evaluation,?Letters in Organic 化學，2013,10(8),594-601
7.Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases，Bioorganic Medicinal 化學，2013,21(14),4192-4200
8.Molecular Docking, QSAR and Molecular 動力學 Simulation on Spiro-oxindoles as MDM2 Inhibitors，Acta Chimica Sinica，2013,71,1396-1403
9.Multicomplex-Based Pharmacophore and QSAR of Aryl-sulfamides as Pyruvate Kinase M2 Activators,?Acta Physico-Chimica Sinica,2013.29,1793-1803
10.Synthesis of cis or trans 4-heteroaromatic substituted 呋喃 and pyrano[3,2-c] tetra- hydroquinolines by onepot imino diels-alder reactions,?Heterocycles, 2013, 87(12),2495- 2500
11.Synthesis and Intestinal Absorption Evaluation Of oligopeptide Prodrugs Based On PepT1,?West China J.Pharm.Sci., 2013,28(3),223-225
12.Preparation and Characterization of Glycyrrhetinic Acid-Modified Poloxamer 188/Chitosan Nanoparticles.?NANO: Brief Reports and Reviews, 2013, 8(4), 1350042-1-8
13.Cell-penetrable lysine dendrimers for anti-cancer drug delivery: synthesis and preliminary biological evaluation，Archiv der Pharmazie,?2014, 347, 469-477
14.Dimer and Tetramer of Gallic Acid: Facile Synthesis, Antioxidant and Antiproliferative Activities，Letters in Drug 設計 & Discovery,?2014, 11, 27-32
15.Diastereoselective，Three-component ，Reaction of Chiral Nickel(II)， Glycinate for Convenient Synthesis of Novel α-amino-β-substituted-γ,γ-disubstituted butyric Acid,?Molecules,2014,19,826-845
16.Discovery and in vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery,?Int. J. 摩爾 Sci., 2014,15, 17565-17576
17.Design, synthesis and biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen with “lock-in” 函數,?European Journal of Medicinal 化學,?2014,82,314-323
18.Efficient Synthesis of Substances Related to Cinacalcet Hydrochloride via Heck Coupling，Synthetic Communications，2014，44，2879-2885
19a novel and convenient route for the construction of 5-((1H-1,2,4-三唑1-yl)甲基) -1H-indoles and its application in the synthesis of Rizatriptan,?Tetrahedron Letters, 2014,55,3938-3941
20.Preparation and characterization of glycyrrhetinic acid-modified poly(乙烯 glycol)-poly(β-benzyl-L-asparate) nanoparticles as liver- targeted delivery system,?Colloid Polym Sci.?,2015,293,319-328
21.Synthesis and Preliminary Evaluation of Novel Bone-targeting NSAIDs Prodrugs based on Glutamic Acid Oligopeptides,?Letters in Drug 設計 & Discovery,?2015, 12, 585-590
22.First synthesis of novel 3,30-bipyridazine derivatives as new potent antihepatocellular carcinoma agents,?Tetrahedron, 2015, 71,7670-7675
23.First synthesis and characterization for the stereoisomers of Ulipristal acetate,?Steroids?,2015,95,7-16
24.First synthesis and characterization of stereoisomers of choleretic drug dihydroxydibutylether,?Chin. J. Chem.?2015, 33, 1145-1152
25.Novel 萘普生peptide-conjugated amphiphilic dendrimer self-assembly micelles for targeting Drug delivery to osteosarcoma cells，RSC Adv.,2016, 6,60327-60335
26.Efficient Synthesis of Fully Substituted Pyrrolidine-fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of 氮丙環 and 3-Ylideneoxindole ,Molecules?,2016, 21,1113-1128
27.銅γ-cyclodextrin complexes immobilized on hexagonal boron nitride as an ef?cient catalyst in the multicomponent synthesis of 1,2,3-三唑，Journal of Catalysis，2016,344，286-292
28.First synthesis of 22-oxa-chenodeoxycholic acid analogue，Steroids， 2016,110,70-76
29.Report on the Synthesis of Isatins via Pyridinum Chlorochromate Catalyzed Intromolecular Cyclization Reactions,Synlett,2016,27,1292-1296
30.Ru(III)-mediated intramolecular ortho-C(sp2)-H activation/oxidative acylation: one-pot synthesis of isatins from α-hydroxy amides，Tetrahedron，2016，72，3193-3197
31.Synthesis Study on the Three Stereoisomers of 4-(3-Hydroxylbutoxy)-2-butanol,?Chemical Journal of Chinese Universities-Chinese,2016,37,493-497
32.Synthesis and Preliminary Study of Indole Croconium as Photoacoustic Imaging Contrast Agent[J].?Chinese Journal of Synthetic 化學, 2017, 25(4): 287-290
33.Ligand-free C-C coupling reaction promoted by hexagonal boron nitride-supported 鈀(II) catalyst in 液態水,Adv.Synth.Catal.,2017,359,454-466
編寫教材
負責四川省精品課程《藥物化學》，編寫國家級規劃教材《藥物化學》、《有機化學》等。
參考資料 >
郭麗 教授(博士生導師).四川大學華西藥學院.2021-12-12