洪學(xué)傳，漢族，是一名教授，任職于武漢大學(xué)藥學(xué)院。他畢業(yè)于天津大學(xué)，并擔(dān)任楚天學(xué)者特聘教授。截至2019年7月，他已發(fā)表13篇論文。
學(xué)習(xí)簡歷
1993.9 - 1997.7 天津大學(xué)攻讀應(yīng)用化學(xué)系精細(xì)化工專業(yè)學(xué)士
1993.9 - 1997.7 天津大學(xué)攻讀管理學(xué)院技術(shù)經(jīng)濟(jì)學(xué)士雙學(xué)位
1997.9 - 1999.11 天津大學(xué)免試攻讀化工學(xué)院應(yīng)用化學(xué)專業(yè)碩士學(xué)位
1999.12 -2000.7 北海道大學(xué)藥學(xué)院和觸媒化學(xué)研究中心研修生
2001.1 - 2005.7 美國密蘇里大學(xué)哥倫比亞分校攻讀有機(jī)化學(xué)博士學(xué)位
工作簡歷
1997.9 - 1999.11 天津大學(xué)化工學(xué)院97級本科生輔導(dǎo)員
1999.12–2000.07 ?日本北海道大學(xué)，藥學(xué)院，研修生
2005.9 - 2007.9美國愛默里大學(xué)博士后研究員
2007.10- 2010. 10AMRI, Albany, NY, USA 資深科學(xué)家
2010.10- 2011.4武漢大學(xué)藥學(xué)院, 教授
2011.5-至今武漢大學(xué)藥學(xué)院, 楚天學(xué)者特聘教授，武漢大學(xué)藥學(xué)院鄧子新院士創(chuàng)新團(tuán)隊(duì)成員。
2017.12 – 至今 ?西藏大學(xué)醫(yī)學(xué)院教授，博士生導(dǎo)師
業(yè)績概要
1)國內(nèi)國際核心化學(xué)期刊上發(fā)表論文37篇及英文專著一章。
2)率先發(fā)現(xiàn)了以手性亞亞胺(sulfoximine)為手性助劑的不對稱的1,4-加成反應(yīng), 使在芳香基團(tuán), 雜環(huán)化合物共扼環(huán)的α位引入手性烷基手性中心更加容易。反應(yīng)具有廣泛 的普遍性和絕對的立體選擇性。
3)在美國國立衛(wèi)生研究院(NIH), 結(jié)核病 Antimicrobial Acquisition and Coordinating Facility (TAACF) 和 CV Therapeutics 的支持下, 利用這特定的化學(xué)設(shè)計(jì), 合成了一系列具有絕對構(gòu)像的抗結(jié)核病的天然或非天然化合物例如(+)-curcumeme, (+)-curcuphenol, pesudoteroxazole, erogorgiaene, colombiasin A 和 elisapterosin B及分子改造, 開發(fā)出了一些選擇性地高, 毒性小的抗結(jié)核劑。
4)發(fā)現(xiàn)用改進(jìn)的aza-Achmatowicz 方法合成多取代吡咯。確定(II)催化吲環(huán)加成串聯(lián)反應(yīng)的相對立體構(gòu)像。設(shè)計(jì), 合成了一系列具有高生物活性的天然化合物例如kopsifoline的核 心結(jié)構(gòu)。
5)曾從事各類癌癥藥物和肥胖癥的小分子藥物等發(fā)現(xiàn)，合成, 研制及工業(yè)開發(fā)。其中一個(gè)臨床III藥在2009年9月得到美國FDA批準(zhǔn)。
獲獎情況
2004Breckenridge Lyons Award for Outstanding Graduate Research, University of Missouri-Colombia
2004Gordon Research Conference on Organic Reactions and Process Chair Award.
2014年獲武漢市第三批“黃鶴英才”人才計(jì)劃。
2014年獲美國化學(xué)會組織頒發(fā)的第九屆世界華人藥學(xué)會最佳報(bào)告獎。
2015年獲武漢大學(xué)醫(yī)學(xué)部醫(yī)學(xué)突出貢獻(xiàn)獎。
2016年武漢大學(xué)珞珈學(xué)者特聘教授，武漢大學(xué)醫(yī)學(xué)部醫(yī)學(xué)突出貢獻(xiàn)獎，武漢大學(xué)朱裕璧醫(yī)學(xué)獎。
研究領(lǐng)域
藥物化學(xué)，有機(jī)化學(xué)，分子影像(Molecular Imaging)
研究興趣與方向
1.活性天然產(chǎn)物的全合成
2.化學(xué)合成藥物的開發(fā)與研究
3.運(yùn)用現(xiàn)代生物學(xué)技術(shù)進(jìn)行藥物開發(fā)
4.用于腫瘤光聲成像的分子探針的研制和開發(fā)
已發(fā)表的學(xué)術(shù)論文
著作：
1.“Recent Progress in the 化學(xué) of 2,1-Benzothiazines”
Xuechuan hong; Michael Harmata. Progress in Hetereocyclic Chemistry, Chapter 1, G. W. Gribble and J. A. joule, eds, Pergamon Press, Vol 20, pp 1–43 (2008)
發(fā)表論文：
1．“Metal-free direct amidation of peptidyl 硫醇 esters with -amino acid esters.” Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng, Green Chem., 2011, 13“The Intramolecular, Stereoselective Addition of Sulfoximine Carbanions to α,β-unsaturated Esters.”Michael Harmata; Xuechuan Hong. J. Am. Chem.l Soc.2003, 125(19), 5754–5756. , 2723
2.
3. “Asymmetric Organocatalysis of [4+3] Cycloaddition Reactions.” Michael Harmata; Sunil K. Ghosh; Xuechuan Hong; Sumrit Wacharasindhu; Patrick Kirchhoe鐵 J. Am. Chem.l Soc. 2003, 125(8), 2058–2059.
4. “A Cycloaddition Protocol for the Assembly of the Heterocyclic Framework Associated with the Kopsifoline alkaloids.”Xuechuan Hong; Stefan France; José M. Mejía-Oneto; Albert Padwa. Org. Lett. 2006, 8, 5141–5144.
5. “Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong. Org. Lett. 2005, 7(16), 3581–3583.
6.“Benzothiazines in Synthesis. Toward the Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong; Charles L. Barnes. Org. Lett.2004, 6(13), 2201–2203.
7."Benzothiazines in Organic Synthesis.The Preparation of Enantiomerically Pure 4-Substituted Quinolones” Michael Harmata; Xuechuan Hong. Org. Lett. 2007, 9, 2901–2904.
8.“Benzothiazines in Synthesis. Stereoselective Synthesis of Erogorgiaene.”Michael Harmata; Xuechuan Hong;Peter R. Schreiner. J. Org. Chem.2008, 73, 1290–1296.
9. “Synthesis of 2,4-Disubstituted Pyrroles by Rearrangements of 2-Furanyl Carbamates.”Sezgin Kiren; Xuechuan Hong; Carolyn A. Leverett; Albert Padwa.Org. Lett. 2009, 11(6), 1233–1235.
10. “A dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.” Xuechuan Hong; Stefan France; Albert Padwa. Tetrahedron, 2007, 63, 5962–5976.
11. “銠 Carbenoid Induced Cycloadditions of Diazo Ketoamides across Indolyl π-Bonds.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Synlett, 2007, 775–779.
12. “Lewis Acid Promoted a-Hydroxy b-Dicarbonyl to a-Ketol Ester Rearrangement.” Xuechuan Hong?a-Oneto; Albert Padwa. Tetrahedron Lett. 2006, 47, 8387–8390.;Jose M. Mej
13. “Photodesulfonylation of Indoles Initiated by Electron Transfer from 三乙胺”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Tetrahedron Lett.2006, 47, 2409–2412.
14. “鈀catalyzed Cross-coupling Reactions of a Sulfoximine with Aryl Dichlorides under 微波 Irradiation.”Michael Harmata; Xuechuan Hong. Synlett, 2007, 969–973.
國際學(xué)術(shù)會議報(bào)告
1. “Studies of the 化學(xué) of 2,1-Benzothiazines and an Approach to the Synthesis of Antitubercular Natural Products.” Xuechuan Hong*nd International Symposium on Organic Synthesis and Drug Development,Nanjing, China, October 14-16, 2010.. Presented at 2
2. “Benzothiazines in Synthesis. Synthesis of Enantiomerically Pure 3,4-Dihydroquinolin-2(1H)-ones.” Michael Harmata; Xuechuan Hong*. ORGN-029l presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.
3. "Benzothiazines in Synthesis. A Route to Chiral Cyclobutanes” Michael Harmata; Weijiang Ying and Xuechuan Hong. ORGN-515 presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.
4.“Benzothiazines in Synthesis. Stereoselective Synthesis of Diastereomers of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. ORGN-060 presented present at the 228 National Meeting of the American Chemical Society, 費(fèi)城, August 22-26, 2004.
5. “微波assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. ORGN-165 presented at the 228 National Meeting of the American Chemical Society, 費(fèi)城, August 22-26, 2004.
6. “Towards a Synthesis of Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.
7. “微波assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.
8.“Benzothiazines in Synthesis. Towards Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. ORGN-061 presented at the 228National Meeting of the American Chemical Society, 費(fèi)城, August 22-26, 2004.
9. “Towards a Synthesis of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. Paper #48 presented at the 38 Annual Midwest Regional Meeting of the American Chemical Society, Colombia, November 5-7, 2003。
參考資料 >
洪學(xué)傳.武漢大學(xué)藥學(xué)院.2021-12-18
洪學(xué)傳教授團(tuán)隊(duì).發(fā)育源性疾病湖北省重點(diǎn)實(shí)驗(yàn)室.2021-12-18