丁建平 男 1982年1月南京大學獲理學學士學位；1984年10月中山大學獲理學碩士學位；1987年10月復旦大學獲理學博士學位。1987年11月至1989年6月，中國科學院上海硅酸鹽研究所博士后。1989年7月至1991年8月，德國柏林自由大學結晶學研究所洪堡基金會獎研金學者。1991年9月至2001年1月，美國新澤西州羅格斯大學，先后任化學與化學生物學系研究助理、研究助理教授、研究副教授，以及高級生物技術和醫學研究中心助理研究員和研究員。2000年11月起，任中科院中國科學院上海生命科學研究院生化細胞所研究員，為中科院“百人計劃”引進的杰出青年學術帶頭人，獲得2001年國家杰出青年基金資助，2006年入選國家人事部“新世紀百千萬人才工程”國家級人選。現任生化細胞所學術委員會副主任，分子生物學國家重點實驗室副主任，“中國生物化學與分子生物學學會”理事、“蛋白質組學專業委員會”副主任委員、“蛋白質科學專業委員會”常務理事；“中國生物物理學會”理事；“中國晶體學會”常務理事；“亞洲晶體學會”常務理事等；中國《生物化學與生物物理學報》《生物化學與生物物理進展》和《生命的化學》編委、英國《The Biochemical Journal》編輯顧問委員會委員等
主要成果
研究領域為結構生物學，研究工作主要是運用蛋白質結晶學、分子生物學、生物化學、細胞生物學等方法，研究生物大分子的結構和功能。目前研究工作主要圍繞一些具有重要生物學意義、并且與重要疾病相關的人源蛋白質的結構和功能進行研究，特別是參與染色質修飾的蛋白質、參與營養和能量調節的mTOR信號轉導通路的蛋白質、以及參與合成和分解代謝過程的重要酶蛋白等。近五年來主持、參與并完成國家、科學院和地方政府的多項重大研究項目。現已在國際重要學術刊物上發表研究論文100多篇，其中包括Nature, Nature Struct Biol, PNAS, embo J, J Biol Chem, Nucleic Acid Res, Structure, J 摩爾 Biol, Biochem J, Virology等。這些研究工作不僅闡述了一些重要蛋白質分子的生物功能的結構基礎、反應機理、結構和功能的關系等一系列科學問題，具有重大的科學意義；同時還為探索與這些蛋白的功能失調相關的疾病的發病機理、尋找疾病診斷的新靶標和新方法、設計和開發抗病毒和抗疾病藥物等奠定了分子基礎，具有重要的潛在應用價值。
主講課程
丁建平所教授課程包括結構生物學、生物化學與分子生物學、實驗生物學、高級生化以及在生物化學夏令營中教授高級生化課程。
社會職務
參考文獻：
主要論文
[1]Yabing Liu, Lejia Hu, Tengfei Ma, Jun Yang, Jianping Ding. Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. SCIENTIFIC REPORTS[J]. 2018, 第 5 作者8(1): 1-12.
[2]Zhong, Chen, Huo, Rongfen, Hu, Kuan, Shen, Jinlong, Li, Dangsheng, Li, Ningli, Ding, Jianping. Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9. JOURNAL OF MOLECULAR RECOGNITION[J]. 2017, 第 7 作者 通訊作者 30(11).
[3]Ma, Tengfei, Peng, Yingjie, Huang, Wei, Ding, Jianping. Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. SCIENTIFIC REPORTS[J]. 2017, 第 4 作者 通訊作者.
[4]Tao, Ye, Zhong, Chen, Zhu, Junjun, Xu, Shutong, Ding, Jianping. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 5 作者 通訊作者 45(10): 5707-5719.
[5]Zhong, Chen, Shen, Jinlong, Zhang, Huibing, Li, Guangyi, Shen, Senlin, Wang, Fang, Hu, Kuan, Cao, Longxing, He, Yongning, Ding, Jianping. Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. CELL REPORTS[J]. 2017, 第 10 作者 通訊作者 20(10): 2328-2340.
[6]Xu, Xiaoyan, Han, Lei, Zhao, Guixian, Xue, Shengjie, Gao, Yunzhen, Xiao, Jun, Zhang, Shicheng, Chen, Peng, Wu, Zhiying, Ding, Jianping, Hu, Ronggui, Wei, Bin, Wang, Hongyan. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2017, 第 10 作者214(1): 209-226.
[7]Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding. Structural basis for Ragulator functioning as a 腳手架 in membrane-anchoring of Rag GTPases and mTORC1. NATURE COMMUNICATIONS[J]. 2017, 第 6 作者 通訊作者 8(1).
[8]Zhang, Shicheng, Wang, Linlin, Tao, Ye, Bai, Tuya, Lu, Rong, Zhang, Tianlong, Chen, Jiangye, Ding, Jianping. Structural basis for the functional role of the Shu complex in homologous recombination. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 8 作者 通訊作者 45(22): 13068-13079.
[9]Wang, Rong, Wang, Zhijing, Wang, Kaikai, Zhang, Tianlong, Ding, Jianping. Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1. JOURNAL OF MOLECULAR CELL BIOLOGY. 2016, 第 5 作者 通訊作者 8(5): 459-461.
[10]Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding, Bing Sun. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 流行性感冒 A viruses. NATURE COMMUNICATIONS[J]. 2016, 第 10 作者 通訊作者 7(1).
[11]Xia, Jing, Wang, Rong, Zhang, Tianlong, Ding, Jianping. Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling. CELL DISCOVERY[J]. 2016, 第 4 作者 通訊作者.
[12]Lv, Fengjuan, Zhang, Tianlong, Zhou, Zhen, Gao, Shuaixin, Wong, Catherine C L, Zhou, JinQiu, Ding, Jianping. Structural basis for Sfm1 functioning as a protein arginine methyltransferase. CELL DISCOVERY[J]. 2015, 第 7 作者 通訊作者 1: 15037.
[13]Qingyu Tang, Caifeng Liu, Chen Zhong, Jianping Ding. 晶體 Structures of Arabidopsis thaliana Nudix Hydrolase NUDT7 Reveal a Previously Unobserved Conformation. 分子植物：英文版[J]. 2015, 第 4 作者8(10): 1557-1559.
[14]Powis, Katie, Zhang, Tianlong, Panchaud, Nicolas, Wang, Rong, De Virgilio, Claudio, Ding, Jianping. 晶體 structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. CELL RESEARCH[J]. 2015, 第 6 作者25(9): 1043-1059.
[15]Fang Yu, Fangyuan He, Hongyan Yao, Chengyuan Wang, Jianchuan Wang, Jianxu Li, Xiaofeng Qi, Hongwei Xue, Jianping Ding, Peng Zhang. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complexStructural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. 2015, 第 9 作者.
[16]Li, Wenjing, Zhang, Tianlong, Ding, Jianping. Molecular basis for the substrate specificity and 催化 mechanism of thymine-7-hydroxylase in fungi. NUCLEIC ACIDS RESEARCH[J]. 2015, 第 3 作者 通訊作者 43(20): 10026-10038.
[17]Zhang, Lun, Wang, JianChuan, Hou, Li, Cao, PengRong, Wu, Li, Zhang, QianSen, Yang, HuaiYu, Zang, Yi, Ding, JianPing, Li, Jia. Functional Role of Histidine in the Conserved His-x-Asp Motif in the 催化 Core of Protein Kinases. SCIENTIFIC REPORTS[J]. 2015, 第 9 作者5(1).
[18]Zhang, Shicheng, Zhang, Tianlong, Yan, Minghui, Ding, Jianping, Chen, JiangYE 晶體 structure of the WOPR-脫氧核糖核酸 complex and implications for Wor1 function in white-opaque switching of Candida albicans. CELL RESEARCH[J]. 2014, 第 4 作者24(9): 1108-1120.
[19]Zhang, Zhe, Zhang, Tianlong, Wang, Shanshan, Gong, Zhou, Tang, Chun, Chen, Jiangye, Ding, Jianping. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. ELIFE[J]. 2014, 第 7 作者 通訊作者.
[20]Zhang, Zhe, Wang, Shanshan, Shen, Tong, Chen, Jiangye, Ding, Jianping. 晶體 Structure of the Rab9A-RUTBC2 RBD Complex Reveals the Molecular Basis for the Binding Specificity of Rab9A with RUTBC2. STRUCTURE[J]. 2014, 第 5 作者 通訊作者 22(10): 1408-1420.
[21]Zhang, Zilong, Wu, Jian, Lin, Wei, Wang, Jin, Yan, Han, Zhao, Wei, Ma, Jun, Ding, Jianping, Zhang, Peng, Zhao, GuoPing. Subdomain II of alpha-Isopropylmalate Synthase Is Essential for Activity INFERRING A MECHANISM OF FEEDBACK INHIBITION. JOURNAL OF BIOLOGICAL 化學[J]. 2014, 第 11 作者289(40): 27966-27978.
[22]Huang, Wei, Gong, Zhen, Li, Jian, Ding, Jianping. 晶體 structure of Drosophila melanogaster 色氨酸 2,3-di氧ase reveals insights into substrate recognition and 催化 mechanism. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2013, 第 4 作者 通訊作者 181(3): 291-299.
[23]Li, Sisi, Du, Jiamu, Yang, Hui, Yin, Juan, Ding, Jianping, Zhong, Jiang. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2013, 第 5 作者 通訊作者 5(1): 64-66.
[24]Yang, Hui, Zhang, Tianlong, Tao, Ye, Wang, Fang, Tong, Liang, Ding, Jianping. Structural insights into the functions of the FANCM-FAAP24 complex in 脫氧核糖核酸 repair. NUCLEIC ACIDS RESEARCH[J]. 2013, 第 6 作者 通訊作者 41(22): 10573-10583.
[25]Ding Jianping. 晶體 structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed lights on the search for 脫氧核糖核酸 decarboxylase. Cell Res.. 2013, 第 1 作者 通訊作者.
[26]Ding, Jianping, Wang, Jianchuan, Zhong, Chen, Wang, Fang. 晶體 structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif. FASEB JOURNAL. 2013, 第 1 作者.
[27]Ding Jianping. Structures of trans-2-enoyl-CoA reductases from 梭菌屬 acetobutulicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism. BIOCHEMJ. 2013, 第 1 作者 通訊作者.
[28]Zha, Manwu, Zhong, Chen, Ou, Ying, Han, Li, Wang, Jianchuan, Ding, Jianping. 晶體 Structures of Human CaMKI alpha Reveal Insights into the Regulation Mechanism of CaMKI. PLOS ONE[J]. 2012, 第 6 作者 通訊作者 7(9).
[29]Li Wenjing, Zhong Chen, Li Lei, Sun Bingfa, Wang Weiyi, Xu Shutong, Zhang Tlanlong, Wang Chunguang, Bao Lhn, Ding Jianping. Molecular basis of the acetyltransferase activity of MEC-17 towards -tubulin. CELL RESEARCH[J]. 2012, 第 10 作者22(12): 1707-1711.
[30]Ding Jianping. Saccharomyces cerevesiae MHF complex structurally resembles the histones (H3H4)2 heterotetramer and functions as a heterotetramer. Structure. 2012, 第 1 作者 通訊作者.
[31]Ding Jianping. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 within the TORC1 activating EGO complex. Structure. 2012, 第 1 作者 通訊作者.
[32]Ding Jianping. A novel 鈣binding site of von illebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood. 2011, 第 1 作者 通訊作者.
[33]Bingfa Sun, Shunling Guo, Qingyu Tang, Chen Li, Rong Zeng, Zhiqi Xiong, Chen Zhong, Jianping Ding. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. 細胞研究：英文版[J]. 2011, 第 8 作者21(8): 1262-1266.
[34]Ding Jianping. Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal unique features of the enzyme. Nucleic Acids Res.. 2011, 第 1 作者 通訊作者.
[35]Wang, Bing, Peng, Yingjie, Zhang, Tianlong, Ding, Jianping. 晶體 structures and kinetic studies of human Kappa class glutathione transferase provide insights into the 催化 mechanism. BIOCHEMICAL JOURNAL[J]. 2011, 第 4 作者 通訊作者 439: 215-225.
[36]Ding Jianping. Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd protein. Cell Biol.. 2011, 第 1 作者 通訊作者.
[37]Chen Zhong Jianping Ding. New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4. 生物化學與生物物理學報：英文版[J]. 2011, 43(5): 337-338.
[38]Chang, Yuanyuan, Wu, Jian, Tong, XiaJing, Zhou, JinQiu, Ding, Jianping. 晶體 structure of the 催化 core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism. BIOCHEMICAL JOURNAL[J]. 2011, 第 5 作者 通訊作者 433: 295-302.
[39]Ding Jianping. Structural basis of the immunosuppressive mechanism of therapeutic antibody daclizumab. Cell Res.. 2010, 第 1 作者 通訊作者.
[40]Li, Yingjie, Du, Jiamu, Zhang, Peng, Ding, Jianping. 晶體 structure of human 銅 homeostasis protein CutC reveals a potential copper-binding site. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2010, 第 4 作者 通訊作者 169(3): 399-405.
[41]Ding Jianping. Crystal structure of Saccaromyces cerevisae tryptophanyl-轉運RNA synthetase: new insights into the mechanism of trptophan activation and implications for anti-fungal drug 設計 Nucleic Acids Res.. 2010, 第 1 作者 通訊作者.
[42]Ding Jianping. 晶體 structure of P. Horikoshi tryptophanyl-轉運RNA synthetase and structure-based phylogenetic analysis suggest an archaeal Origin of tryptophanyl-tRNA synthetases. Nucleic Acids Res.. 2010, 第 1 作者 通訊作者.
[43]Bei Yang, Chen Zhong, Yingjie Peng, Zheng Lai, Jianping Ding. Molecular mechanisms of ＂off-on switch＂ of activities of human IDH1 by tumor-associated mutation R132H. 細胞研究：英文版[J]. 2010, 第 5 作者1188-1200.
[44]Hui Yang, Jianchuan Wang, Baozhen Peng, Huaizu Guo, Yajun Guo, Jianping Ding, Jiamu Du, Dapeng Zhang. Structural Basis for the Blockage of IL-2 Signaling by Therapeutic Antibody Basiliximab. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2010, 第 6 作者.
[45]Ding Jianping. Molecular basis of the acceleration of the nucleotide exchange of Rheb by TCTP. J. Biol. Chem.. 2009, 第 1 作者 通訊作者.
[46]Du, Jiamu, Yang, Hui, Guo, Yajun, Ding, Jianping. Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. MOLECULAR IMMUNOLOGY[J]. 2009, 第 4 作者46(11-12): 2419-2423.
[47]Sheng Li, Hao Wang, Baozhen Peng, Meilan Zhang, Daipong Zhang, Sheng Hou, Yajun Guo, Jianping Ding. Efalizumab binding to the LFA-1 α L I domain blocks ICAM-1 binding via steric hindrance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009, 第 8 作者106(11): 4349-4354.
[48]Zhang, Tianlong, Li, Sheng, Zhang, Yichen, Zhong, Chen, Lai, Zheng, Ding, Jianping. 晶體 Structure of the ARL2-GTPBART Complex Reveals a Novel Recognition and Binding Mode of Small GTPase with Effector. STRUCTURE[J]. 2009, 第 6 作者 通訊作者 17(4): 602-610.
[49]Zhang, Peng, Ma, Jun, Zhang, Zilong, Zha, Manwu, Xu, Hai, Zhao, Guoping, Ding, Jianping. Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from 鉤端螺旋體屬 interrogans. BIOCHEMICAL JOURNAL[J]. 2009, 第 7 作者 通訊作者 421: 133-143.
[50]Ding Jianping. Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of ?-2-microglobulin by antibody BBM.1. J. Mol. Recognition. 2009, 第 1 作者 通訊作者.
[51]Ma, Jun, Zhang, Peng, Zhang, Zilong, Zha, Manwu, Xu, Hai, Zhao, Guoping, Ding, Jianping. Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from 鉤端螺旋體屬 interrogans. BIOCHEMICAL JOURNAL[J]. 2008, 第 7 作者 通訊作者 415(1): 45-56.
[52]Shen, Ning, Zhou, Minyu, Yang, Bei, Yu, Yadong, Dong, Xianchi, Ding, Jianping. 催化 mechanism of the 色氨酸 activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states. NUCLEIC ACIDS RESEARCH[J]. 2008, 第 6 作者 通訊作者 36(4): 1288-1299.
[53]Du, Jiamu, Hou, Sheng, Zhong, Chen, Lai, Zheng, Yang, Hui, Dai, Jianxin, Zhang, Dapeng, Wang, Hao, Guo, Yajun, Ding, Jianping. Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid 關節炎 JOURNAL OF MOLECULAR BIOLOGY[J]. 2008, 第 10 作者382(4): 835-842.
[54]Sun, Bingfa, Hong, Jing, Zhang, Peng, Dong, Xianchi, Shen, Xu, Lin, Donghai, Ding, Jianping. Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36. JOURNAL OF BIOLOGICAL 化學[J]. 2008, 第 7 作者283(52): 36504-36512.
[55]Ding Jianping. Isoquinoline-1,3,4-trione derivatives inactivates caspase-3 by generation of reactive oxygen 物種 J. Biol. Chem.. 2008, 第 1 作者 通訊作者.
[56]Du, Jiamu, Wang, Hao, Zhong, Chen, Peng, Baozhen, Zhang, Meilan, Li, Bohua, Hou, Sheng, Guo, Yajun, Ding, Jianping. 晶體 structure of chimeric antibody C2H7 Fab in complex with a CD20 多肽 MOLECULAR IMMUNOLOGY[J]. 2008, 第 9 作者45(10): 2861-2868.
[57]Ding Jianping. Molecular mechanism of ADPR hydrolysis by human NUDT5 from structural and kinetic studies. J. Mol. Biol.. 2008, 第 1 作者 通訊作者.
[58]Ma Tengfei, Peng Yingjie, Huang Wei, Liu Yabing, Ding Jianping. The β and γ subunits play distinct functional roles in the α 2 βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase. SCIENTIFIC REPORTS. 第 5 作者.
[59]Xu Shaoqiong, Zhang Tianlong, Kompella Shiva N., Yan Mengdi, Lu Aiping, Wang Yanfang, Shao Xiaoxia, Chi Chengwu, Adams David J., Ding Jianping, Wang Chunguang. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic 乙酰膽堿 receptors. SCIENTIFIC REPORTS. 第 10 作者5.
[60]Peng Yingjie, Zhong Chen, Huang Wei, Ding Jianping. Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction. PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY. 第 4 作者17(9): 1542-1554.
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參考資料 >
丁建平.中國科學院大學.2024-10-25