歐陽(yáng)松應(yīng) 博士 研究員，男，中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)會(huì)員，北京市科技新星計(jì)劃入選者。
基本信息
歐陽(yáng)松應(yīng) 博士 研究員
中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)會(huì)員
北京市科技新星計(jì)劃入選者
研究方向：病原體感染與脫氧核糖核酸識(shí)別天然免疫反應(yīng)分子機(jī)制研究
研究工作
1997.07-2001.09 南昌大學(xué) 生物科學(xué)工程系 學(xué)士
2001.08-2004.07 吉林大學(xué)（農(nóng)學(xué)部）生物化學(xué)與分子生物學(xué)教研室 碩士
2004.08-2007.06 北京協(xié)和醫(yī)學(xué)院－清華大學(xué)醫(yī)學(xué)部 基礎(chǔ)所生物化學(xué)與分子生物學(xué)系 博士
2007.07-2010.08 中國(guó)科學(xué)院生物物理研究所 助理研究員
2010.09-2013.11 中國(guó)科學(xué)院生物物理研究所 副研究員
2013.12-至今 中國(guó)科學(xué)院生物物理研究所 研究員
（2013年12月獲中國(guó)科學(xué)院生物物理研究所“青年研究員計(jì)劃”支持）
獲獎(jiǎng)情況
2014年度北京市科技新星計(jì)劃入選者
2013年榮獲中科院“盧嘉錫青年人才獎(jiǎng)”
研究方向
病毒感染與脫氧核糖核酸識(shí)別天然免疫反應(yīng)分子機(jī)制研究
代表論文
1. Jiao L*, Ouyang S*, Shaw N, Song G, Feng Y, Niu F, Qiu W, Zhu H, Hung LW, Zuo X, Shtykova E, Zhu P, 越南盾 YH, Xu R#, Liu ZJ#. Mechanism of the Rpn13-induced activation of Uch37
2. Gu J, Feng Y, Feng X, Sun C, Lei L, Ding W, Niu F, Jiao L, Yang M, Li Y, Liu X, Song J, Cui Z, Han D, Du C, Yang Y, Ouyang S#, Liu ZJ#, Han W#. Structural and biochemical characterization reveals LysGH15 as an unprecedented “EF-hand-like” 鈣binding phage lysin
3. Zhang L, Mo J, Swanson K, Wen H, Petrucelli A, Gregory S, Zhang Z, Schneider M, Jiang Y, Fitzgerald K, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan J, Ting J. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the 脫氧核糖核酸 sensor STING
4. Zhao L*, Hua T*, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Jiang Y, Hung LW, Liu L, Ye K, Ouyang S#, Cheng G#, Liu ZJ#. Structural analysis of AEP reveals activation mechanism and reversible maturation intermediate. 細(xì)胞 Res
5. Niu F, Ru H, Ding W, Ouyang S#, Liu ZJ#. Structural biology study of human TNF receptor associated factor 4 TRAF domain
6. Niu F*, Shaw N*, Wang Y*, Jiao L*, Ding W, Upurd H, Ouyang S#, Cheng G#, Liu ZJ#. From the Cover: Structure of the LeanyerOrthobunyavirus NucleoproTEIN核糖核酸 complex reveals novel 建筑 for RNA encapsidation
7. Jiao L*, Ouyang S*, Liang M*, Niu F*, Shaw N, Wu W, Ding W, Jin C, Peng Y, Zhu Y, Zhang F, Wang T, Li C, Zuo X, Luan CH, Li D, Liu ZJ. Structure of severe fever with thrombocytopenia 綜合征 病毒 nucleoprotein in complex with Suramin reveals therapeutic potentials
8. Shaw N, Ouyang S, Liu ZJ. Binding of bacterial secondary messenger molecule c di-GMP is a STING operation
9. Parvatiyar K*, Zhang Z*, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
10. Ouyang S*, Song X*, Wang Y*, Ru H*, Shaw N, Jiang Y, Niu F, Zhu Y, Qiu W, Parvatiyar K, Li Y, Zhang R, Cheng G, Liu ZJ. Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
11. Zhan Z*, Ouyang S*, Liang W, Zhang Z, Liu ZJ, Huang L. Structural and functional characterization of the C-terminal 催化 domain of the SSV1 integrase
12. Ouyang S*, Gong B*, Li JZ*, Zhao L*, Wu W, Zhang FS, Sun L, Wang SJ, pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y, Liu ZJ, Liang M. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus
13. Liang W*, Ouyang S*, Shaw N, Joachimiak A, Zhang R, Liu ZJ. Conversion of D-ribulose 5-磷酸鹽 to D-木酮糖 5-phosphate: new insights from structural and biochemical studies on human RPE
14. Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. Regulation of apoptosis by Bat3-enhanced YWK-II protein/APLP2 stability
15. Yin XQ*, Ouyang S*, Xu WM*, Zhang XP, Fok K.L., Zhang JP, Miao SY, Chan HC, and Wang LF. YWK-II as a novel Go protein-coupled receptor for Müllerian Inhibiting Substance in 細(xì)胞 活下去survival J Cell Sci
16. Qiu XB*, Ouyang S*, Li CJ, Miao S, Wang L, Goldberg AL. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37
人物成就
2022年9月23日消息，福建師范大學(xué)生命科學(xué)學(xué)院歐陽(yáng)松應(yīng)教授團(tuán)隊(duì)聯(lián)合福建佰孟醫(yī)學(xué)科技有限公司，成功研發(fā)猴痘病毒熒光PCR檢測(cè)試劑盒（熒光探針?lè)ǎ⑷〉脷W盟CE認(rèn)證，獲得CE注冊(cè)證書(shū)。這意味著該試劑盒可在歐盟國(guó)家以及認(rèn)可歐盟CE認(rèn)證的國(guó)家銷(xiāo)售。
參考資料 >
福建省成功研發(fā)猴痘病毒檢測(cè)試劑盒.今日頭條·臺(tái)海網(wǎng).2022-09-24