王宏偉，博士，教授，博士生導師，現任清華大學黨委委員、生命科學學院院長。他曾任清華大學生命科學學院教授、博士生導師，以及清華-北大生命科學聯合中心PI和清華-北大結構生物學高精尖創新中心研究員。王宏偉的主要研究方向包括更高效、更高分辨率的冷凍電鏡技術開發，細胞骨架和生物膜系統的協調機制，以及核酸質量控制的分子機制和調控。2016年4月，王宏偉接替國際著名結構生物學家施一公成為清華大學生命科學學院第三任院長。
人物經歷
1992-1996?清華大學生物科學與技術系，學士
1996-2001 清華大學生物科學與技術系，博士
2001-2006?美國勞倫斯伯克利國家實驗室生命科學部，博士后
2006-2008 美國勞倫斯伯克利國家實驗室生命科學部，研究科學家
2009-2011 耶魯大學分子生物物理與生物化學系，終身教授Track助理教授
2010.12?清華大學生命科學學院，教授、博導
2016年4月 清華大學生命科學學院院長。
研究領域
利用冷凍電子顯微學研究生物大分子復合體的結構與分子機理。
主要研究方向如下：
1. 更高效、更高分辨率的冷凍電鏡方法學開發；
2. 細胞骨架和生物膜系統的協調機制；
3. 核酸質量控制的分子機制和調控。
主要成就
科研成就
長期致力于使用冷凍電鏡技術研究生物大分子的結構以及其組裝機制，研究領域集中在細胞骨架動態機理、核糖核酸降解、RNA干擾以及冷凍電鏡方法學。目前已獲得微管和Exosome等的高分辨電鏡結構。此外，還與其他課題組合作，解析了一批具有重要生物學意義的生物大分子的結構。
論文
1. Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang HW*, Wang J*, Xu Y*. (2018) Cryo-EM structure of human ATR-ATRIP complex. Cell Research, 28(2):143-156
2. Liu Z, Wang J, 成姓 H, Ke X, Sun L, Zhang Q, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203
3. Mei K, Li Y, Wang S, Shao G, Wang J, Ding Y, Luo G, Yue P, Liu JJ, Wang X, Dong MQ, Wang HW*, Guo W*. (2018) Cryo-EM structure of the exocyst complex. Nat. Struct. 摩爾 Biol., 25(2):139-146
4. Fan X, Zhao L, Liu C, Zhang JC, Fan K, Yan X, peng HL, Lei J*, Wang HW*. (2017) Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by 計算機科學Corrected Cryo-EM. Structure, 25:1623-1630.
5. Ma M, Liu JJ, Li Y, Huang Y, Ta N, Chen Y, Fu H, Ye MD, Ding Y, Huang W, Wang J, 越南盾 MQ, Yu L*, Wang HW*. (2017) Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human pi3kC3C1 and -C2. Cell Research, 27(8):989-1001
6. Zheng JX, Li Y, Ding YH, Liu JJ, Zhang MJ, 越南盾 MQ, Wang HW*, Yu L*. (2017) 建筑 of the ATG2B-WDR45 complex and an aromatic Y/HF motif crucial for complex formation. Autophagy, 13(11):1870-1883
7. Xu J, Zhao L, Xu Y, Zhao W, Sung P*, and Wang HW*. (2017) Cryo-EM structures of human RAD51 recombinase filaments during catalysis of 脫氧核糖核酸strand exchange. Nat. Struct. 摩爾 Biol., 24:40-46
8. Wang HW*, and Wang JW. (2017) How cryo-electron microscopy and X-ray crystallography complement each other. Protein Sci., 26:32-39 (Review)
9. Wang HW*, 雷姓 J*, and Shi Y*. (2017) Biological cryo-electron microscopy in China. Protein Sci., 26:16-31 (Review)
10. Yang H, Wang J, Liu M, Chen X, Huang M, Tan D, Dong MQ, Wong CC, Wang J*, Xu Y*, and Wang HW*. (2016) 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1. Protein 細胞, 7:878-887
11. Agrawal RK*, Wang HW*, and Belfort M*. (2016) Forks in the tracks: Group II introns, spliceosomes, telomeres and Beyond 核糖核酸 Biol., 13:1218-1222
12. Liu JJ, Niu CY, Wu Y, Tan D, Wang Y, Ye MD, Liu Y, Zhao W, Zhou K, Liu QS, Dai J, Yang X, 越南盾 MQ, Huang N, and Wang HW*. (2016) CryoEM structure of 酵母浸膏 cytoplasmic exosome complex. Cell Research, 26:822-837
13. Qu G, Kaushal PS, Wang J, Shigematsu H, Piazza CL, Agrawal RK*, Belfort M*, and Wang HW*. (2016) Structure of a group II intron in complex with its reverse transcriptase. Nat. Struct. 摩爾 Biol., 23:549-557
14. Qin S, Yin H, Yang C, Dou Y, Liu Z, Zhang P, Yu H, Huang Y, Feng J, Hao J, Hao J, Deng L, Yan X, 越南盾 X, Zhao Z, Jiang T, Wang HW, Luo SJ, and Xie C*. (2016) A magnetic protein biocompass. Nat Mater., 15:217-226
15. Jia N, Liu N, 成姓 W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW*, Chen Y*, and Zhou CZ*. (2016) Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports, 17:235-248
16. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J*, Wang HW*, and Wang J*. (2015) An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy 數據 Protein 細胞, 6:919-923 (Letter)
17. Wang HW*. (2015) Opening new doors for understanding eukaryotic 核糖核酸 splicing.Sci China Life Sci., 58:1171-1172 (Editorial Material)
18. Hu Z, Zhou Q, Zhang C, Fan S, 成姓 W, Zhao Y, Shao F, Wang HW, Sui SF*, and Chai J*. (2015) Structural and biochemical basis for induced self-propagation of NLRC4. Science, 350:399-404
19. Tomko RJ Jr*, Taylor DW, Chen ZA, Wang HW, Rappsilber J, and Hochstrasser M*. (2015) A single α helix drives extensive remodeling of the proteasome lid and completion of regulatory particle assembly. 細胞, 163:432-444
20. Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, 常姓 J, Xia B, Fan S, Zhang D, Wang J*, Wang HW*, and Chai J*. (2015) Structural basis for specific recognition of single-stranded 核糖核酸 by Toll-like receptor 13. Nat. Struct. 摩爾 Biol., 22, 782-787.
21. Zhou Q, Huang X, Sun S, Li X, Wang HW*, and Sui SF*. (2015) Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research, 25:551-560.
22. Chang S, Sun D, Liang H, Wang J, Li J, Guo L, Wang X, Guan C, Boruah BM, Yuan L, Feng F, Yang M, Wang L, Wang Y, Wojdyla J, Li L, Wang J, Wang M, Cheng G, Wang HW*, and Liu Y*. (2015) Cryo-EM Structure of 流行性感冒 病毒 核糖核酸 Polymerase Complex at 4.3 A Resolution. 摩爾 Cell, 57:925-935.
23. Liu JJ, Bratkowski MA, Liu X, Niu CY, Ke A*, and Wang HW*. (2014) Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM. Nat. Struct. Mol. Biol., 21:95-102.
24. Li Y, Hsin J, Zhao L, 成姓 Y, Shang W, Huang KC, Wang HW, and Ye S*. (2013) FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation. Science, 341:392-295.
25. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA*, and Wang HW*. (2013) Substrate-specific structural rearrangements of human Dicer. Nat. Struct. 摩爾 Biol., 20:662-670.
26. Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, and Wolin SL*. (2013) An 核糖核酸 degradation machine sculpted by Ro autoantigen and noncoding RNA. Cell, 153:166-177.
27. Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, and Wang HW*. (2012) Structural insight into WHAMM-mediated cytoskeletal coordination during membrane remodeling. J. 細胞 Biol., 199:111-124.
28. Zhou K, Kanai R, Lee P, Wang HW*, and Modis Y*. (2012) Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin. J. Struct. Biol., 177:402-409.
29. Liu XQ, and Wang HW*. (2011) Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt method. J. Vis. Exp., doi: 10.3791/2574.
30. Wu X, Shen QT, Stokes N, Lu C, Zheng Q, Polak L, Wang HW, and Fuchs E*. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. 細胞, 144:341-352.
31. Wang HW*, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA*, and Nogales E*. (2009) Structural insights into 核糖核酸 processing by the human RISC-loading complex. Nat. Struct. 摩爾 Biol., 16:1148-1153.
32. Wang HW, Long S, Ciferri C, Westermann S, Drubin DG, Barnes G, and Nogales E*. (2008) 建筑 and flexibility of the 酵母浸膏 Ndc80 kinetochore complex. J. Mol. Biol., 383:894-903.
33. Wang HW*, Wang J, Ding F, Callahan K, Bratkowski MA, Bulter JS, Nogales E, and Ke A*. (2007) Architecture of the yeast Rrp44-exosome complex suggests routes of 核糖核酸 recruitment for 3’-end processing. Proc. Natl. Acad. Sci. USA, 104:16844-16849.
34. Wang HW, Ramey VH, Westermann S, Leschziner A, Welburn JPI, Nakajima Y, Drubin DG, Barnes G, and Nogales E*. (2007) 建筑 of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat. Struct. 摩爾 Biol., 14:721-726.
35. Westermann W, Wang HW, Avila-Sakar A, Drubin DG, Nogales E, and Barnes G*. (2006) The Dam1 kinetochore ring complex moves processively on depolymeRizing microtubule ends. Nature, 440:565-569.
36. Wang HW, and Nogales E*. (2005) The nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature, 435:911-915.
人才培養
教育方法
王宏偉每年年底都會給實驗室同學寫寄語，并表示自己最關注的仍然是同學們是否在做科研過程中學會了尋找問題的能力、掌握了新的方法學手段、學會了批判性思考和合理設計實驗的技巧。他更希望同學們在讀書期間學會調節自己的情緒、安排自己的時間、獲得獨立的思維、掌握自己的命運，為自己的未來打下一個良好的基礎。
講授課程
王宏偉堅持參與教學和學生培養工作，年度平均授課54學時。此外，他還主持建立了清華北大生命科學聯合中心研究生課程《現代生物學技術》。
科普報告
2014年起，王宏偉曾分別在大學、中學、小學做過多場科普報告。
獲得榮譽
參考資料 >
學為人師，行為世范.清華大學.2024-07-05
王宏偉 博士.清華大學生命科學學院.2024-07-05
科學探索獎獲得者王宏偉∣面對這些情況，要勇于說“不”.清華校友總會.2024-07-05
歷任領導.清華大學生命科學學院.2024-07-05
王宏偉-清華大學.清華大學.2024-07-05
清華大學生命科學學院院長易人，王宏偉接替施一公.澎湃新聞.2024-07-05
王宏偉：排開所有活動陪學生一起做實驗.人民網.2024-09-05