向嵩，利用結構生物學、生物化學等手段來研究蛋白質等生物大分子的結構與功能的聯系，理解它們功能的分子機理。
研究方向
1)對核受體等重要的轉錄因子的結構與功能的研究；
2)對在脫氧核糖核酸的損傷反應過程中起重要作用的蛋白的結構與功能的研究。
近期論文
1. Xiang S, Callaghan MM, Watson KG, Tong L. A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc Natl Acad Sci U S A. 2009 Dec; 106 (49): 20723-27.
2. Sinturel F, Pellegrini O, Xiang S, Tong L, Condon C, Bénard L, Real-時間 fluorescence detection of exoribonucleases. 核糖核酸 2009 Nov; 15(11): 2057-62.
3. Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L, A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10; 17(6): 823-32.
4. Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L, Structure and function of the 5’®3’ exoribonuclease Rat1 and its activating partner Rai1. Nature. 2009 Apr 9; 458(7239): 784-8.
5. Xiang S, Usunow G, Lange G, Busch M, Tong L. 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a crucial enzyme for isoprenoids biosynthesis. Book chapter, T.J. Bach Ed. (in press)
6. Xiang S, Tong L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct 摩爾 Biol. 2008 Mar; 15(3): 295-302.
7. Khan JA*, Xiang S*, Tong L. Crystal structure of human nicotinamide riboside kinase. Structure. 2007 Aug; 15(8): 1005-13. (*-equal contribution authors)
8.Xiang S, Usunow G, Lange G, Busch M, Tong L. Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem. 2007 Jan 26; 282(4): 2676-82.
9. Nichols JD, Xiang S, Schindelin H, Rajagopalan KV. Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft. Biochemistry. 2007 Jan 9; 46(1): 78-86.
10. Xiang S, Kim EY, Connelly JJ, Nassar N, Kirsch J, Winking J, Schwarz G, Schindelin H. The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine 核苷酸 exchange factor. J 摩爾 Biol. 2006 May 26; 359(1): 35-46.
11. Tian G, Xiang S, Noiva R, Lennarz WJ, Schindelin H. The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell. 2006 Jan; 124(1): 61-73.
12. Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C. Structural insights into sulfite oxidase deficiency. J Biol Chem. 2005 Sep 30; 280(39): 33506-15.
13. Xiang S, Nicolas J, Rajagopalan KV, Schindelin H. The crystal structure of 埃希氏菌屬 coli MoeA and its relationship to the multifunctional protein gephyrin. Structure. 2001 Apr 4; 9(4): 299-310.
14. Sato S, Xiang S, Raleigh D. On the relationship between protein stability and folding kinetics: a comparative study of the N-terminal domains of RNase HI, E. coli and 芽孢桿菌屬 stearothermophilus L9. J 摩爾 Biol. 2001 Sep 21; 312(3): 569-77.
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