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郭國驥，男，1983年4月12日出生，現任浙江大學醫學院教授，博士生導師。

2014年由浙江大學高層次人才引進計劃從哈佛大學醫學院引進并全職回國，成為浙江大學最年輕的教授之一。2015年入選中組部“國家青年”，2017年獲“國家優秀青年基金”。其科研團隊主要利用單細胞分析技術研究干細胞的再生和分化機制。

人物經歷

教育經歷

工作經歷

2010.8-2010.10新加坡基因研究所博士后

2010.11-2014.9哈佛大學醫學院 Research Fellow

2014.10-浙江大學醫學院教授、博士生導師

2020年，獲“霍英東教育基金會第十七屆高等院校青年教師獎”。

主要成就

研究方向

干細胞與再生醫學

高通量單細胞分析技術

細胞圖譜

人工智能

一、建立了高通量單細胞分析技術的若干實驗方法以及數據分析手段。

二、繪制世界首個小鼠細胞圖譜和首個人類細胞圖譜，并建立基于圖譜的單細胞比對系統。

三、利用單細胞分析技術系統性的解析了小鼠造血干細胞的再生與分化機制。

四、利用單細胞分析技術解析了小分子組合誘導重編程的機制，并為再生醫學的細胞來源問題提供了新的思路。

郭國驥團隊自主研發了低成本、高效率、完全國產化的高通量單細胞分析平臺，并利用這一平臺構建了全球首個小鼠細胞圖譜和首個人類細胞圖譜

利用單細胞基因表達譜分析的手段來研。究干細胞的分化路徑和分化機制，開辟了單細胞系統生物學新領域。建立并優化了高通量單細胞定量PCR的基本實驗方法，以及數據分析手段。構建Microwell-seq高通量單細胞分析平臺，并繪制全球首個哺乳綱細胞圖譜。在胚胎期干細胞系統和成體造血干細胞系統中發現了譜系基因預表達的現象，解析了這一現象的分子機制，并進一步闡明了其對干細胞終端分化的影響。五年內在Cell, Cell Stem Cell, Developmental Cell等著名期刊發表學術論文10余篇，總影響因子180分，總引用率650余次。

2020年3月26日，世界首個人類細胞圖譜日前在浙江大學繪制成功。國際頂級期刊《自然》在線刊登了浙江大學醫學院郭國驥教授團隊的這項最新研究成果。

發表文章

Han X, Chen H, Huang D, Chen H, Fei L, Cheng C, Huang H, Yuan GC,Guo G. Mapping human pluripotent stem cell differentiation pathways using high throughput single-cell 核糖核酸sequencing. Genome Biol. 2018 Apr 5;19(1):47.

Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, Mao J, Chen Y, Lu C, Xie J, Fang Q, Wang Y, Yue R, Li T, Huang H, Orkin SH, Yuan GC, Chen M,Guo G. Mapping the Mouse Cell Atlas by Microwell-Seq.Cell. 2018 Feb 22; 172(5):1091-1107.e17.

Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH,Guo G. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res. 2017 Mar;27(3):386-401.

Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R,Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ?H. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016 Mar 3;531(7592):53-8.

Guo G#，Pinello L, Han X, Lai S, Shen L, Lin TW, Zou K, Yuan GC#, Orkin SH#. Serum-based culture conditions provoke gene expression variability in mouse embryonic stem cells as revealed by single cell analysis. Cell Rep. 2016 Jan 19;14(4):956-65. #Co-corresponding authors.

Saadatpour A, Lai S,Guo G#, Yuan GC#. Single-Cell Analysis in Cancer Genomics. Trends 獛屬 2015 Oct;31(10):576-86. doi: 10.1016/j.tig.2015.07.003. #Co-corresponding authors.

Saadatpour A*,Guo G*, Orkin SH, Yuan GC. Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biol. Genome Biol. 2014 Dec 3;15(12):525. doi: 10.1186/s13059-014-0525-9. *世界斯諾克中國公開賽first authors.

Graham SL, Wicher KB, Jedrusik A,Guo G, Herath W, Robson P and Zernicka-Goetz M. BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo. Nat Commun. 2014 Dec 16;5:5667. doi: 10.1038/ncomms6667.

Marco E, Karp RL,Guo G, Robson P, Hart AH, Trippa L, Yuan GC. Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5643-50. doi: 10.1073/pnas.1408993111. Epub 2014 Dec 15.

Lundberg P, Takizawa H, Kubovcakova L,Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. J Exp Med. 2014 Oct 20;211(11):2213-30. doi: 10.1084/jem.20131371. Epub 2014 Oct 6.

Riddell J, Gazit R, Garrison BS,Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 2014 Apr 24;157(3):549-64. doi: 10.1016/j.cell.2014.04.006.

Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D,Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. 摩爾 Cell. 2014 Jan 9;53(1):32-48. doi: 10.1016/j.molcel.2013.11.011. Epub 2013 Dec 19.

Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 2013 Oct 3;13(4):492-505. doi: 10.1016/j.stem.2013.07.017. Epub 2013 Sep 12.

Kim W, 鳥綱 GH, Neff T,Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct;9(10):643-50. doi: 10.1038/nchembio.1331. Epub 2013 Aug 25.

Kerenyi MA, Shao Z, Hsu YJ,Guo G, Luc S, O'Brien K, Fujiwara Y, peng C, Nguyen M, Orkin SH. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2013 Jun 18;2:e00633. doi: 10.7554/eLife.00633.

Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B,Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D, Fu XY. A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev. 2013 Jun 15;27(12):1378-90. doi: 10.1101/gad.221176.113.

Maclean GA, Menne TF,Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17567-72. doi: 10.1073/pnas.1215468109. Epub 2012 Oct 8.

Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85. doi:10.1016/j.devcel.2010.02.012.

Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P,Guo G, Robson P, Draper JS, Rossant J. Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development. 2010 Feb;137(3):395-403. doi:10.1242/dev.038828.

Yuan P, Han J,Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH. Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev. 2009 Nov 1;23(21):2507-20. doi: 10.1101/gad.1831909.

Jedrusik A, Parfitt DE,Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P, Zernicka-Goetz M. Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell 質量 in the mouse embryo. Genes dev 2008 Oct 1;22(19):2692-706. doi: 10.1101/gad.486108.