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魏文勝，男，現(xiàn)任北京大學(xué)生命科學(xué)學(xué)院研究員，博士生導(dǎo)師。

重要經(jīng)歷

教育經(jīng)歷：

1999 - 2004，博士后，遺傳學(xué)，Stanford Unversity

1995 - 1999，理學(xué)博士，遺傳學(xué)，密歇根大學(xué) State University

1987 - 1991，理學(xué)學(xué)士，生物化學(xué)，北京大學(xué)

工作經(jīng)歷：

2016 — 現(xiàn)在研究員，北京未來基因診斷高精尖創(chuàng)新中心（ICG）

2015 — 現(xiàn)在研究員，北大-清華大學(xué)生命科學(xué)聯(lián)合中心（CLS）

2014 — 現(xiàn)在研究員，北京大學(xué)生物醫(yī)學(xué)集成創(chuàng)新研究所（BIOPIC）

2007 — 現(xiàn)在研究員，北京大學(xué)生命科學(xué)學(xué)院，生化與分子生物學(xué)

2005 — 2007 Research Associate，美國斯坦福大學(xué)醫(yī)學(xué)院遺傳學(xué)系

1999 — 2004 博士后，美國斯坦福大學(xué)醫(yī)學(xué)院遺傳學(xué)系

科研領(lǐng)域

研究領(lǐng)域：

真核生物基因組編輯及高通量功能基因組學(xué)，疾病與感染的分子機制。

研究方向：

著重發(fā)展和應(yīng)用基因組編輯技術(shù)，涵蓋編碼及非編碼序列的高通量功能基因組學(xué)、生物動態(tài)光學(xué)成像及精準(zhǔn)醫(yī)療。在此基礎(chǔ)上，特別關(guān)注宿主細胞參與病原菌感染的分子機制，為發(fā)展宿主導(dǎo)向的治療手段提供新的藥物靶點和思路。

代表性論文

1. Ren Q, Li C, Yuan P, Cai C, Luo G, Zhang L and Wei W , A Dual-Reporter System for Real-時間 Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C 病毒 , Sci. Rep. , 2015 , 5, 8865; DOI:10.1038/srep08865 , [Abstract] , [Full Text]

2. peng J, Zhou Y, Zhu S and Wei W , High-throughput Screens in Mammalian Cells Using the CRISPR-Cas9 System , FEBS Journal , 2015 , DOI: 10.1111/febs.13251 , [Abstract] , [Full Text],State-of-the-Art Review

3. Shen J, Cai C, Yu Z, Pang Y, Zhou Y, Qian L, Wei W and Huang Y , A microfluidic live cell assay to study 炭疽病毒素 induced cell lethality assisted by conditioned medium , Sci. Rep. , 2015 , 5, 8651; DOI:10.1038/srep08651 , [Abstract] , [Full Text]

4. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Feng H and Wei W , Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile 毒素 B , Cell Res. , 2015 , 25:157–168 , [Abstract] , [Full Text], published online 30 December 2014 (Cover story)

5. Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Liu L, Chen Y-G, Wu W , S-G2 phase enriched β-catenin/TCF complex ensures survival and cell cycle progression , Journal of Cell Science , 2014 , 127(22):4833-45. doi: 10.1242/jcs.146977. Epub 2014 Sep 18. , [Abstract] , [Full Text]

6. Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi , 思愛普regulated T 細胞APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions , Journal of Immunology , 2014 , 193(8):3860-71. doi: 10.4049/jimmunol.1401660. Epub 2014 Sep 12. , [Abstract] , [Full Text]

7. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W , High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells , Nature , 2014 , 509:487-91 , [Full Text],(AOP)

8. Qian LL, Cai CZ, Yuan PF, Jeong SY, Yang XZ, Almeida VD, Ernst J, Costa M, Cohen SN, and Wei WS , Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of 炭疽病毒素 uptake , Sci China Life Sci , 2014 , 57:469–481 , [Full Text],Cover

9. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W , A Complete Decoding of 脫氧核糖核酸 Recognition by TAL Effector RVDs , 細胞 Res. , 2014 , 24:628-631 , [Full Text]

10. Yang J, Yuan P, Wen D , Sheng Y, Zhu S, Yu Y, Gao X and Wei W , ULtiMATE system for rapid assembly of customized TAL effectors , PLoS One , 2013 , 8:e75649 , [Abstract] , [Full Text]

11. Lih C, Wei W, and Cohen SN. , Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. , Genes Dev. , 2006 , 20, 2082-2095. , [Abstract] , [Full Text]

12. Wei W, Lu Q, Chaudry J, Leppla S, and Cohen SN. , The LDL 捕手related protein LRP6 mediates internalization and lethality of 炭疽病毒素 , 細胞 , 2006 , 124, 1141-1154. , [Abstract] , [Full Text]

13. Lu Q, Wei W, Kowalski P, Chang A, and Cohen SN , EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to 炭疽病毒素 , Proc. Natl. Acad. Sci. USA , 2004 , 101, 17246-51 , [Abstract] , [Full Text]

14. Wei W, Plovanich Jones A, Deng W, Jin Q, Collmer A, Huang H, and He SY , The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in 假單胞菌屬 syringae pv. tomato , Proc. Natl. Acad. Sci. USA , 2000 , 97, 2247-52 , [Full Text]

15. Roine E, Wei W*, Yuan J, Nurmiaho-Lassila EL, Kalkkinen N, Romantschuk M, He SY , Hrp pilus: an hrp-dependent bacterial surface appendage produced by 假單胞菌屬 syringae pv. tomato DC3000 , Proc. Natl. Acad. Sci. USA , 1997 , 94, 3459-64 , [Full Text],(*Co-first author)

16. Gopalan S, Wei W, and He SY , hrp gene-dependent induction of hin1: a plant gene activated rapidly by both harpins and the avrPto gene-mediated signal. , Plant J. , 1996 , 10, 591-600. , [Abstract]