趙要風，1970年生，博士，中國農業大學生物化學與分子生物學系教授，博士生導師，國家杰出青年基金獲得者。主要研究領域為動物分子遺傳學。
人物經歷
2006年3月至: 中國農業大學生物學院, 校特聘教授
1998年8月至2006年3月: Karolinska Institute, Stockholm, Sweden, postdoctoral fellow
1995年9月至1998年6月:中國農業大學動物科學技術學院動物遺傳育種專業, 獲博士學位
1992年9月至1995年6月: 中國農業大學生物學院動物生理生化專業, 獲碩士學位
1988年9月至1992年6月: 河南大學生物系生物學專業,獲學士
社會兼職
2008起任Developmental and Comparative Immunology雜志編委。近年來分別為國際SCI雜志Journal of Immunology, Molecular Biology and Evolution, European Journal of Immunology, Developmental and Comparative Immunology, Mucosal Immunology進行同行論文審稿，并為美國國家自然科學基金進行項目評審。
研究方向
在前期工作的基礎上，課題組的主要研究方向包括：
- 脊椎動物免疫基因的比較和進化研究
- 免疫球蛋白（抗體）轉運機制研究
- 非駱駝科動物來源重鏈抗體（納米抗體）生產平臺的建立與應用
- 家養動物病毒抗性相關基因的高通量篩選
人物成就
科研成果
趙要風教授在低等脊椎動物中首次發現具有明確鏈區的抗體新類型并命名為IgF。在鴨嘴獸中發現一種新型哺乳綱免疫球蛋白并命名為IgO。首次在家養動物中發現IgD及其特殊的表達機制。在兩棲綱、爬行綱及原始哺乳動物鴨嘴獸中發現IgD基因，為理解IgD在脊椎動物中的進化提供了重要線索。此外，他還發現了豬促卵泡素b亞基（FSHβ）基因是影響豬產仔數（包括總產仔數、產活仔數）的主效基因或遺傳標記。
承擔項目
- 中國農業大學人才引進項目(2006-2008)
- 863高科技計劃(2006-2010)
- 自然科學基金(2007-2009)
- 教育部新世紀優秀人才支持計劃(2007-2010)
- 國家杰出青年基金(2008-2011)
發表論文
在PNAS, Journal of Experimental Medicine, Journal of Immunology, JBC等刊物上發表SCI論文近30篇。發表論文90余篇，被引2000余次。其中包括以下近期發表的論文：
- 2018
- Identification of a Transcriptionally 前鋒 α Gene and Two υ Genes within the Pigeon (Columba livia) IgH Gene Locus. Huang T, Wang X, Si R, Chi H, Han B, Han H, Cao G*, Zhao Y*. J Immunol. 2018 Jun 1;200(11):3720-3728.
- Truncation of the Murine Neonatal Fc Receptor Cytoplasmic Tail Does Not Alter IgG 新陳代謝 or Transport In vivo Ma Y, Ke C, Wan Z, Li Z, Cheng X, Wang X, Zhao J, Ma Y, Ren L, Han H*, Zhao Y*. J Immunol. 2018 Feb 15;200(4):1413-1424.
- Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IG一級方程式錦標賽 expression and induces skeletal muscle hypertrophy. Zou Y, 越南盾 Y, Meng Q, Zhao Y*, Li N*. Sci Rep. 2018 Feb 9;8(1):2781.
- 2017
- Convergent and divergent genetic changes in the genome of Chinese and European pigs. Wang J, Zou H, Chen L, Long X, Lan J, Liu W, Ma L, Wang C, Xu X, Ren L, Gu Z, Li N, Hu X, Zhao Y*, Zhao Y*. Sci Rep. 2017 Aug 17;7(1):8662
- A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck. Yang Z, Sun Y, Ma Y, Li Z, Zhao Y, Ren L, Han H, Jiang Y*, Zhao Y*. Sci Rep. 2017 Jan 30;7:41426.
- 2016
- Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern 巴爾的摩金鶯隊 Han B, Yuan H, Wang T, Li B, Ma L, Yu S, Huang T, Li Y, Fang D, Chen X, Wang Y, Qiu S, Guo Y, Fei J, Ren L, pan-Hammarstr?m Q, Hammarstr?m L, Wang J, Wang J, Hou Y, Pan Q*, Xu X*, Zhao Y*. J Immunol. 2016 Jun 15;196(12):5138-47
- Internal Duplications of DH, JH, and C Region Genes Create an Unusual IgH Gene Locus in Cattle. Ma L, Qin T, Chu D, Cheng X, Wang J, Wang X, Wang P, Han H, Ren L, Aitken R, Hammarstr?m L, Li N, Zhao Y*. J Immunol. 2016 May 15;196(10):4358-66.
- 2014
- Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish. Zhang T, Tacchi L, Wei Z, Zhao Y*, Salinas I*. Immunogenetics. 2014 May;66(5):335-51.
- 2013
- Extensive diversification of IgH 亞綱-encoding genes and IgM subclass switching in crocodilians. Cheng G, Gao Y, Wang T, Sun Y, Wei Z, Li L, Ren L, Guo Y, Hu X, Lu Y, Wang X, Liu G, Zhang C, Yu J, panHammarstr?m Q, Hammarstr?m L, Wu X, Li N, Zhao Y*. Nat Commun. 2013;4:1337.
- A comparative overview of immunoglobulin genes and the generation of their diversity in tetrapods.Sun Y, Wei Z, Li N, Zhao Y*. Dev Comp Immunol. 2013 Jan;39(1-2):103-9. (*corresponding author)
- 2012
- Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates. Sun Y, Liu Z, Li Z, Lian Z, Zhao Y*. front Immun奧林匹克里昂女子足球隊 2012 Dec 20;3:392.
- Expressional analysis of immunoglobulin D in cattle (Bos taurus), a large domesticated 有蹄動物 Xu B, Wang J, Zhang M, Wang P, Wei Z, Sun Y, Tao Q, Ren L, Hu X, Guo Y, Fei J, Zhang L, Li N, Zhao Y*. PLoS One. 2012;7(9):e44719.
- Extensive diversification of IgD-, IgY-, and truncated IgY(δFc)-encoding genes in the 紅色-eared turtle (Trachemys scripta elegans). Li L, Wang T, Sun Y, Cheng G, Yang H, Wei Z, Wang P, Hu X, Ren L, Meng Q, Zhang R, Guo Y, Hammarstr?m L, Li N, Zhao Y. J Immun奧林匹克里昂女子足球隊 2012 Oct 15;189(8):3995-4004.
- Immunoglobulin genes and diversity: what we have learned from domestic animals. Sun Y, Liu Z, Ren L, Wei Z, Wang P, Li N, Zhao Y. J Anim Sci Biotechnol. 2012 Jun 20;3(1):18.
- Evidence of IgY 亞綱 diversification in snakes: evolutionary implications. Wang T, Sun Y, Shao W, Cheng G, Li L, Cao Z, Yang Z, Zou H, Zhang W, Han B, Hu Y, Ren L, Hu X, Guo Y, Fei J, Hammarstr?m L, Li N, Zhao Y*. J Immun奧林匹克里昂女子足球隊 2012 Oct 1;189(7):3557-65.
- Immunoglobulin genomics in the guinea pig (Cavia porcellus). Guo Y, Bao Y, Meng Q, Hu X, Meng Q, Ren L, Li N, Zhao Y*. PLoS One. 2012;7(6):e39298.
- Analysis of immunoglobulin transcripts in the ostrich Struthio camelus, a primitive avian 物種 Huang T, Zhang M, Wei Z, Wang P, Sun Y, Hu X, Ren L, Meng Q, Zhang R, Guo Y, Hammarstrom L, Li N, Zhao Y*. PLoS One. 2012;7(3):e34346.
- 2011
- Characterization of the MHC class II α-chain gene in ducks. Ren L, Yang Z, Wang T, Sun Y, Guo Y, Zhang Z, Fei J, Bao Y, Qin T, Wang J, Huang Y, Hu X, Zhao Y*, Li N*. Immunogenetics. 2011 Oct;63(10):667-78.
- A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana). Guo Y, Bao Y, Wang H, Hu X, Zhao Z, Li N, Zhao Y*. PLoS One. 2011 Feb 25;6(2):e16889.
- The immunoglobulin δ gene in jawed vertebrates: a comparative overview. Sun Y, Wei Z, Hammarstrom L, Zhao Y. Dev Comp Immun奧林匹克里昂女子足球隊 2011 Sep;35(9):975-81.
- 2010
- A comprehensive analysis of germline and expressed immunoglobulin repertoire in the horse. Sun Y, Wang C, Wang Y, Zhang T, Ren L, Hu X, Zhang R, Meng Q, Guo Y, Fei J, Li N, Zhao Y*. Dev Comp Immunol. 2010 Sep;34(9):1009-1020.
- Phylogeny, genomic organization and expression of lambda and kappa immunoglobulin light chain genes in a reptile, Anolis carolinensis. Wu Q, Wei Z, Yang Z, Wang T, Ren L, Hu X, Meng Q, Guo Y, Zhu Q, Robert J, Hammarstrom L, Li N*, Zhao Y*. Dev Comp Immunol. 2010 May; 34(5):579-89.
- The immunoglobulin gene loci in the teleost Gasterosteus aculeatus. Bao Y*, Wang T, Guo Y, Zhao Z, Li N, Zhao Y*. Fish Shellfish Immunol. 2010 Jan;28(1):40-8.
- 2009
- Expression of IgM, IgD, and IgY in a reptile, Anolis carolinensis. Wei Z, Wu Q, Ren L, Hu X, Guo Y, Warr GW, Hammarstr?m L, Li N, Zhao Y*. J Immunol. 2009 Sep 15;183(6):3858-64.
- Ornithorhynchus anatinus (鴨嘴獸) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods. Zhao Y*, Cui H, Whittington CM, Wei Z, Zhang X, Zhang Z, Yu L, Ren L, Hu X, Zhang Y, Hellman L, Belov K, Li N, Hammarstr?m L*. J Immunol. 2009 Sep 1;183(5):3285-93.
- 2008
- Genomic organization of the immunoglobulin light chain gene loci in Xenopus tropicalis: evolutionary implications. Qin T, Ren L, Hu X, Guo Y, Fei J, Zhu Q, Butler JE, Wu C, Li N, Hammarstrom L, Zhao Y*. Dev Comp Immunol. 2008;32(2):156-65.
- 2007
- Physical mapping of the giant panda immunoglobulin heavy chain constant region genes. Zhao Z， Zhao Y，panHammarstr?m Q, Liu W, Liu Z, Zhao Y, Li N, Hammarstr?m L. Dev Comp Immunol. 2007;31(10):1034-49.
- 2006
- Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis. Zhao Y*, panHammarstr?m Q, Yu S, Wertz N, Zhang X, Li N, Butler JE, Hammarstr?m L*. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12087-92.
- The bovine antibody repertoire. Zhao Y, Jackson SM, Aitken R. Dev Comp Immunol. 2006;30(1-2):175-86.
- 2005
- Selective IgG2 deficiency due to a point mutation causing abnormal splicing of the Cg2 gene. Zhao Y*, panHammarstr?m Q, Zhao Z, Wen S, Hammarstr?m L. Int Immunol. 2005 Jan;17(1):95-101.
- Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis. Zhao Y*, pan-Hammarstr?m Q, Zhao Z, Hammarstr?m L. Dev Comp Immunol. 2005;29(1):61-71.
- 2003
- Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn alpha chain. Zhao Y, Kacskovics I, Zhao Z, Hammarstr?m L. Vet Immunol Immunopathol. 2003 Dec 15;96(3-4):229-33.
- The porcine Ig delta gene: unique chimeric splicing of the first constant region domain in its heavy chain transcripts. Zhao Y*, panHammarstr?m Q, Kacskovics I, Hammarstr?m L. J Immunol. 2003 Aug 1;171(3):1312-8.
- Physical mapping of the bovine immunoglobulin heavy chain constant region gene locus. Zhao Y, Kacskovics I, Rabbani H, Hammarstrom L. J Biol Chem. 2003 Sep 12;278(37):35024-32.
- Cloning of the complete rat immunoglobulin delta gene: evolutionary implications. Zhao Y, Hammarstr?m L. Immunology. 2003 Mar;108(3):288-95.
- 2002
- Artiodactyl IgD: the missing link. Zhao Y*, Kacskovics I, Pan Q, Liberles DA, Geli J, Davis SK, Rabbani H, Hammarstrom L. J Immunol. 2002 Oct 15;169(8):4408-16.
- 2000
- Mapping of the chicken immunoglobulin heavy-chain constant region gene locus reveals an inverted alpha gene upstream of a condensed upsilon gene. Zhao Y, Rabbani H, Shimizu A, Hammarstr?m L. Immunology. 2000 Nov;101(3):348-53.
專利情況
現有美國專利一項
獲獎記錄
- 2002年度教育部自然科學一等獎
- 2003年度國家技術發明二等獎
參考資料 >
趙要風.中國農業大學生物學院.2024-03-29