王學(xué)東在醫(yī)藥企業(yè)工作多年,主要從事抗生素發(fā)酵以及生物、生化藥物的研發(fā)與生產(chǎn)方面的工作,具有豐富的實際生產(chǎn)工作經(jīng)驗。
個人職位
工學(xué)博士,副研究員。
研究方向
從事應(yīng)用微生物發(fā)酵及酶催化方向的理論與應(yīng)用方面的研究。
工作經(jīng)歷
在華東理工大學(xué)大學(xué)生工學(xué)院從事科研工作,研究方向是生物催化與轉(zhuǎn)化以及相關(guān)的應(yīng)用微生物發(fā)酵過程,通過理論與實際應(yīng)用方面的研究,著力開發(fā)其工業(yè)化應(yīng)用的潛能。承擔(dān)或參與了多項研究課題,主要有:手性氨基酸的酶法拆分;基因工程菌發(fā)酵法制備腺苷甲硫氨酸;生物轉(zhuǎn)化法制備神經(jīng)節(jié)脂GM1等。在國內(nèi)外檢索期刊上發(fā)表論文十余篇,申請國家發(fā)明專利三項,獲省部級科技進步三等獎兩項。
論著成果
1. Xuedong Wang, etc. (2004) Development of an 吸附 process for the direct separation and purification of prodigiosin from culture broth. Biotechnology Applied Biochemistry 40(3): 277-280.
2. Xuedong Wang, etc (2004) Simple method for large-scale isolation and purification of gangliosides by non-ionic 吸附 chromatography Preparative Biochemistry & Biotechnology 34(4): 305–313.
3. Xuedong Wang, etc. Strategy for the improvement of prodigiosin production by a Serratia marcescens mutant through fed-batch 發(fā)酵 World Journal of Microbiology and Biotechnology, 2005 21(6-7),969-972
4. Xuedong Wang, etc (2005) Highly efficient conversion of polysialoganglioside to GM1 with 短桿菌屬 casei as a microbial biocatalyst Biocatalysis and Biotransformation 23(1): 29-32
5. Xuedong Wang, etc (2005) Reducing by-product formation in L-lactic acid 發(fā)酵 by Rhizopus oryzae Journal of Industrial Microbiology & Biotechnology 32: 38-40
6. Yanfeng Peng, Xuedong Wang, Dongzhi Wei (2007) Development of a large scale process for the conversion of polysialogangliosides to monosialotetrahexosylganglioside with a novel strain of 短桿菌屬 casei producing sialidase Biotechnology Letters 29:885-889
7.Jianguo Zhang, Xuedong Wang, Yu Zheng, Guochen Fang, Dongzhi Wei (2008) Enhancing yield of S-adenosylmethionine in 畢赤酵母屬 pastoris by controlling NH4 concentration Bioprocess Biosyst. Eng. 31:63–67
8.Jian-Guo Zhang, Xue-Dong Wang, Ji-Ning Zhang, 越南盾Zhi Wei (2008) 氧 Vectors Used for 腺苷甲硫氨酸 Production in Recombinant 畢赤酵母屬 pastoris with Sorbitol as Supplemental 碳 Source JOURNAL OF BIOSCIENCE AND BIOENGINEERING 105(4):335-340
9. Jian-Guo Zhang, Xue-Dong Wang, 越南盾Zhi Wei (2009) High-level production of bovine enterokinase light chain using fed-batchs by recombinant 畢赤酵母屬 pastoris Chemical Biochemical Engineering 23(2):219-224
10. 張建國,王學(xué)東,魏東芝(2008)高效液相色譜法同時測定Pichia pastoris發(fā)酵過程中腺苷甲硫氨酸相關(guān)的六種物質(zhì) 工業(yè)微生物 38(1):6-9
11. 張建國,王學(xué)東,張魯嘉,周英,魏東芝,李軍(2008)利用Pichia pastoris生產(chǎn)S-腺苷甲硫氨酸的發(fā)酵工藝 工業(yè)微生物 38(3):6-11
12. Jianguo Zhang, Xuedong Wang, Erzheng Su, Guochen Fang, Yuhong Ren, DongzhiWei (2008) A new 發(fā)酵 strategy for S-adenosylmethionine production in recombinant 畢赤酵母屬 pastoris Biochemical Engineering Journal 41:74-78
13. Xu tao,Lujia Zhang, Erzheng Su, Dongbing Cui, Xuedong Wang, Dongzhi Wei (2010)Disparity in productive binding mode of the slow-reacting enantiomer determines the novel 催化 behavior of 假絲酵母屬 antarctica lipase B Journal of Molecular Catalysis B: Enzymatic 62 (2010) 288–296
申請專利
專利名稱:一種分離制備靈菌紅素的方法
發(fā)明人:魏東芝,王學(xué)東,沈亞領(lǐng)
申請?zhí)枺?/p>
公開(公告)號: CN1563400
專利名稱:單唾液酸四己糖神經(jīng)節(jié)苷脂的制備方法
發(fā)明人:魏東芝,尹,沈亞領(lǐng),王學(xué)東
申請?zhí)枺?/p>
公開(公告)號:1570080
獲獎情況:多酚氧化酶和生物催化過程應(yīng)用關(guān)鍵技術(shù),上海市科技進步三等獎(2005)
生物轉(zhuǎn)化法制備單唾液酸神經(jīng)節(jié)苷脂GM1,上海市科技進步三等獎(2006)
參考資料 >