管吉松，男，現任上海科技大學生命科學與技術學院博士生導師。
課題組簡介
研究方向
學習記憶的神經編碼與細胞環路機制。
研究內容
探索哺乳動物大腦中的記憶存儲和提取背后的編碼規律和機制。
（1）開發大規模單神經元解析度的在體成像技術，尋找和追蹤記憶活動和多模態信息存儲；
（2）解析記憶神經環路以及其表觀遺傳調控；
（3）利用腦機接口等工程與醫學手段，探索對腦損傷、腦疾病的修復治療新方法。
研究成果展示
通過大規模神經活動信號在體內記錄的方法揭示了特異性場景記憶儲存在稀疏分布的皮層II層神經元中。基于皮層環路的神經環路結構，提出了新的記憶介導的認知模型。針對記憶印跡神經元深入研究，發現了SUV39H1、HDAC2等調控因子在神經元活動后誘發的表觀遺傳過程中的作用，確立了記憶穩定性的調控機制。融合人工智能技術，發展新型腦機接口，以用于記憶損傷相關疾病的診斷和治療。部分成果發表在國際頂級雜志上（包括《自然》、《細胞》、《Nature 神經科學》和《美國國家科學院院刊》等）。
代表性論文
1. Guan, Ji-Song*; Haggarty, Stephen J.; Giacometti, Emanuela; Dannenberg, Jan-Hermen; Joseph, Nadine; Gao, Jun; Nieland, Thomas J. F.; Zhou, Ying; Wang, Xinyu; Mazitschek, Ralph; Bradner, James E.; DePinho, Ronald A.; Jaenisch, Rudolf; Tsai, Li-Huei .HDAC2 negatively regulates memory formation and synaptic plasticity.NATURE. 2009. 459(7243):55-U58.
2. Xie, Hong*; Liu, Yu; Zhu, Youzhi; Ding, Xinlu; Yang, Yuhao; Guan, Ji-Song .In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(7):2788-2793.
3. Guan, Ji-Song *; Xie, Hong; Ding, XinLu.The role of epigenetic regulation in learning and memory.EXPERIMENTAL NEUROLOGY. 2015. 268:30-36.
4. Zhu, Tao*; Liang, Chen; Li, Dongdong; Tian, 苗族苗族; Liu, 苯乙烯-丙烯腈共聚物xiong; Gao, Guanjun; Guan, Ji-Song .Histone 甲基transferase Ash1L mediates activity-dependent repression of neurexin-1 alpha.SCIENTIFIC REPORTS. 2016. 6.
5. Guan, Ji-Song *; Jiang, Jun; Xie, Hong; Liu, Kai-Yuan.How Does the Sparse Memory "Engram" Neurons Encode the Memory of a Spatial-Temporal Event?.FRONTIERS IN NEURAL Circuits 2016. 10.
6. Ding, Xinlu*; Liu, Sanxiong; Tian, Miaomiao; Zhang, Wenhao; Zhu, Tao; Li, Dongdong; Wu, Jiawei; Deng, HaiTeng; Jia, Yichang; Xie, Wei; Xie, Hong; Guan, Ji-Song .Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation.NATURE 神經科學 2017. 20(5):6900.
7. Jiang, Jun*; Wang, Guang-Yu; Luo, Wenhan; Xie, Hong; Guan, Ji-Song .Mammillary body regulates state-dependent fear by alternating cortical oscillations.SCIENTIFIC REPORTS. 07 Sep 2018. 8.
8. Fu, Ruxing*; Luo, Wenhan; Nazempour, Roya; Tan, Daxin; Ding, He; Zhang, Kaiyuan; Yin, Lan; Guan, Jisong ; Sheng, Xing .Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces.ADVANCED OPTICAL MATERIALS. 05 Feb 2018. 6(3).
9. Zhang, Jing*; Liu, Xiaojun; Xu, Wenjing; Luo, Wenhan; Li, Ming; Chu, Fangbing; Xu, Lu; Cao, Anyuan; Guan, Jisong; Tang, Shiming; Duan, Xiaojie .Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in vivoNANO LETTERS. May 2018. 18(5):2903-2911.
10. Zhao, Yu*; Liu, Changbo; Liu, Zhixiang; Luo, Wenhan; Li, Lizhu; Cai, Xue; Liang, 越南盾; Su, Yuanzhe; Ding, He; Wang, Qiang; Yin, Lan; Guan, Jisong; Luo, Minmin; Sheng, Xing .Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals.IEEE TRANSACTIONS ON ELECTRON DEVICES. Jan 2019. 66(1):785-792.
11. Li, Dong*; Zavaglia, Melissa; Wang, Guangyu; Xie, Hong; Hu, Yi; Werner, Rene; Guan, Ji-Song; Hilgetag, Claus C. .Discrimination of the hierarchical structure of cortical layers in 2-photon microscopy data by combined unsupervised and supervised machine learning.SCIENTIFIC REPORTS. 15 May 2019. 9.
12. Li, 越南盾*; Wang, Guangyu; Xie, Hong; Hu, Yi; Guan, Ji-Song ; Hilgetag, Claus C. .Multimodal Memory Components and Their Long-Term 動力學 Identified in Cortical Layers II/III but Not Layer V.FRONTIERS IN INTEGRATIVE 神經科學 01 Oct 2019. 13(54).
13. Wang, Guangyu*; Xie, Hong; Wang, Lun; Luo, Wenhan; Wang, Yixiang; Jiang, Jun; Xiao, Chun; Xing, Feng; Guan, Ji-Song .Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.CEREBRAL CORTEX. Dec 2019. 29(12):5085-5097.
14. Liu, Shiguo*; Tian, Miaomiao; He, Fan; Li, Jiani; Xie, Hong; Liu, Wenmiao; Zhang, Yeting; Zhang, Ru; Yi, Mingji; Che, Fengyuan; Ma, Xu; Zheng, Yi; Deng, Hao; Wang, Guiju; Chen, Lang; Sun, Xue; Xu, Yinglei; Wang, Jingli; Zang, Yucui; Han, Mengmeng; Wang, Xiuhai; Guan, Hongzai; Ge, Yinlin; Wu, Chunmei; Wang, Haiyan; Liang, Hui; Li, Hui; Ran, Ni; Yang, Zhaochuan; Huang, Huanhuan; Wei, Yanzhao; Zheng, Xueping; Sun, Xiangrong; Feng, Xueying; Zheng, Lanlan; Zhu, Tao; Luo, Wenhan; Chen, Qinan; Yan, Yuze; Huang, Zuzhou; Jing, Zhongcui; Guo, Yixia; Zhang, Xuzhan; Schaaf, Christian P.; Xing, Jinchuan; Wang, Chuanyue ; Yu, Fuli ; Guan, Ji-Song .Mutations in ASH1L confer susceptibility to Tourette SyndromeMOLECULAR PSYCHIATRY. Feb 2020. 25(2):476-490.
參考資料 >
管吉松.上海科技大學生命科學與技術學院.2022-01-25