沈敬山，男，1981年畢業(yè)于長春冶金地質(zhì)學(xué)校，1981-1992年在山東省地勘局工作。1995 年獲中國藥科大學(xué)藥物化學(xué)專業(yè)碩士學(xué)位，1998年獲中國科學(xué)院上海藥物研究所藥物化學(xué)專業(yè)博士學(xué)位。
主要成就
科研成就
研究方向
藥物發(fā)現(xiàn)與成藥性評估（中樞神經(jīng)系統(tǒng)與心血管系統(tǒng)藥物研究）;綠色可持續(xù)性有機(jī)合成路線設(shè)計、工藝研究和產(chǎn)業(yè)化。
科研成果
已有三個化學(xué)仿制藥品種的新藥證書。共有六個化學(xué)仿制藥和四個中藥仿制藥研制成功并上市。目前，具有自主知識產(chǎn)權(quán)的候選新藥TPN729（用于ED）已于2011年12月份作為1.1類化學(xué)藥品上報國家食品藥品監(jiān)督管理總局申請臨床研究。TPN171（用于ED與PAH）、TPN507（用于精神分裂癥）、TPN102（用于癲癇）在臨床前研究階段。已申請藥物研究方面的專利二十多項(xiàng)，獲授權(quán)專利六項(xiàng)。
設(shè)計出了多條具有自主知識產(chǎn)權(quán)、更適于生產(chǎn)實(shí)際應(yīng)用的新路線，使成本消耗更低，化學(xué)過程更簡易、可控、安全，并且最大程度地減少對人員健康和環(huán)境資源的不利影響。目前已申請了三十多項(xiàng)工藝專利，獲授權(quán)專利九項(xiàng)，有多個項(xiàng)目（如替米沙坦、順阿曲庫等）的節(jié)能降耗與清潔操作實(shí)用化方案應(yīng)用于工業(yè)生產(chǎn)中。
科研項(xiàng)目
成功主持或參與了“新藥創(chuàng)制”國家重大專項(xiàng)、國家863計劃、科技支撐計劃、國家自然科學(xué)基金等多項(xiàng)國家級及上海市的重大專項(xiàng)或基金項(xiàng)目
代表
Guan Wang, Zheng Liu, Tiantian Chen, Zhen Wang, Huaiyu Yang, Mingyue Zheng, Jing Ren, Guanghui Tian, Xiaojun Yang, Li Li, Jianfeng Li, Jin Suo, Rongxia Zhang, Xiangrui Jiang, Nicholas Kenneth Terrett, Jingshan Shen*, Yechun Xu*, Hualiang Jiang*. Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5. J. Med. Chem
Yongjun Mao, Zheng Liu, Xiaojun Yang, Xiangfei Xia, Rongxia Zhang, Jianfeng Li, Xiangrui Jiang, Kai Xie, Jin Zheng, Hui Zhang, Jin Suo, Jingshan Shen*. A New and Improved Process for N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)乙酰胺 Org. Process Res. Dev
Qiang Zhang, Jian-Feng Li, Guang-Hui Tian, Rong-Xia Zhang, Jin Sun, Jin Suo, Xin Feng, Du Fang, Xiang-Rui Jiang*, Jing-Shan Shen. A Practical and Enantioselective Synthesis of Tapentadol. Tetrahedron: Asymmetry
Zhijian Xu, Zheng Liu, Tong Chen, TianTian Chen, Zhen Wang, Guanghui Tian, Jing Shi, Xuelan Wang, Yunxiang Lu, Xiuhua Yan, Guan Wang, Hualiang Jiang, Kaixian Chen, Shudong Wang, Yechun Xu, Jingshan Shen*, and Weiliang Zhu*. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. Journal of Medicinal 化學(xué)
Zhi Chen, Guanghui Tian, Zhen Wang, Hualiang Jiang, Jingshan Shen*, Weiliang Zhu*. Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity. J. Chem. Inf. Model
Yongjun Mao, Guanghui Tian, Zheng Liu, Jingkang Shen, Jingshan Shen*. An Improved Synthetic Route for Preparative Process of 鹽酸伐地那非 Org. Process Res. dev
Xiangrui Jiang, Jianfeng Li, Rongxia Zhang, Hongli Guo, Shaolei Huang, Jingshan Shen*. Improved Preparation of 3-(1,1-Dimethylallyl)decursinol. J. Heterocycl. Chem
Hongliang Duan, Jin Zheng, Qinglin Lai, Zheng Liu, Guanghui Tian, Zhen Wang, Jianfeng Li, Jingshan Shen*. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6. Bioorg. Med. Chem. Lett
Xiangrui Jiang; Jianfeng Li; Rongxia Zhang; Yi Zhu; Jingshan Shen*. An Improved Preparation Process for 吉西他濱 Org. Process Res. Dev
Qingjie Zhao, Yuanyuan Lou, Ruisheng Xiong, Haihong Li, Jingshan Shen*. Regioselective Synthesis of 4azido-Neu2en5,7Ac21Me and its intramolecular Transformation to 4azido-Neu2en5,9Ac21Me. Carbohydr. Res.
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