張緒穆，1961年10月出生于湖北省鄂州市，是一位著名的配位化合物和金屬有機化學家。他曾在武漢大學、中國科學院福建物質結構研究所、加利福尼亞大學-圣地亞哥分校和斯坦福大學學習，并于1992年獲得博士學位。他曾在美國賓夕法尼亞州立大學和羅格斯-羅格斯大學擔任終身教授，并于2015至2018年間擔任南方科技大學化學系講座教授及系主任。他長期致力于手性藥物的綠色、催化不對稱合成，以及不對稱氫化和手性膦配體兩個領域的研究。他還是南方科技大學化學系系主任、綠色催化研究所所長、賓州州立大學教授、坪山生物醫藥研究院院長等職位的擔任者。他于2022年當選為俄羅斯工程院外籍院士，同年當選為中國化學會會士。
人物經歷
張緒穆，1982年畢業于武漢大學化學系，獲學士，1992年畢業于斯坦福大學(Stanford)化學系，獲博士學位。1992年至1994年在斯坦福大學(Stanford University)化學系做博士后研究。1994年至1999年于賓夕法尼亞州立大學（Penn State University）任助理教授，1999年至2003年于賓州州立大學（Penn State University）任副教授，2003年9月至今于賓州州立大學（Penn State University）任教授。已發表文章90多篇，專利及專利申請42件，曾多次被邀請在國際會議上做報告（正式受邀演講:210次，其他受邀演講:75次）。并且是美國凱瑞生化有限公司(Chiral Quest Inc)的創始人和首席技術總監。
2015年，就任南方科技大學化學系系主任。
研究方向
研究方向：有機化學、金屬有機化學、生物無機化學。
主要貢獻
近期代表性研究論文：
1.Catalytic Enantioselective Desymmetrization of Meso Cyclic Anhydrides via 銥Catalyzed Hydrogenation. Liu, T. L.; Li, W.; Geng, H. L.; Wang, C. J.; Zhang, X. M. Organic Letters. 2013, 15, 1740.
2.Rhodium-Catalyzed Asymmetric Hydroformylation of 1,1-Disubstituted Allylphthalimides: A Catalytic Route to β3-Amino Acids. Zheng, X.; Cao, B. N.; Liu, T. L.; Zhang, X. M. Advanced Synthesis & Catalysis. 2013, 355, 679.
3.Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via 銠Catalyzed Hydroaminomethylation. Li, S. K.; Huang, K. X.; Zhang, J. W.; Wu, W. J.; Zhang, X. M. Organic Letters. 2013, 15, 1036.
4.A Novel Triphosphoramidite Ligand for Highly Regioselective Linear Hydroformylation of Terminal and Internal Olefins Chen, C. Y.; Qiao, Y.; Geng, H. L.; Zhang, X. M. Organic Letters. 2013, 15, 1048.
5.銠Catalyzed Enantioselective Hydrogenation of Oxime Acetates.Huang, K. X.; Li, S. K.; Chang, M. X.; Zhang, X. M. Organic Letters. 2013, 15, 484.
6.Highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes. Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu. Angew. Chem. Int. Edit. 2012, 51, 10679. DOI: 10.1002/anie.201202715
7.New tetraphosphorus ligands for highly linear selective hydroformylation of allyl and vinyl derivatives. Cai, Chaoxian; Yu, Shichao; Cao, Bonan; Zhang, Xumu. Chem. Eur. J. 2012, 18, DOI: 10.1002/chem.201201396.
8.Access to both enantiomers of α-chloro-β-keto esters with a single chiral ligand: highly efficient enantioselective chlorination of cyclic β-keto esters catalyzed by chiral 銅(II) and 鋅(II) complexes of a spiro-2,2'-bischroman-based bisoxazoline ligand. Li, Jie; pan, Wei; Wang, Zheng; Zhang, Xumu; Ding, Kuiling. Adv. Synth. Catal. 2012, 354, 1980.
9.Highly enantioselective hydrogenation of β-ketoenamides with the Rh-ZhangPhos catalyst. Huang, Kexuan; Zhang, Xiaowei; Geng, Huiling; Li, Sheng-kun; Zhang, Xumu. ACS Catalysis 2012, 2, 1343.
10.Highly regioselective isomerization-hydroaminomethylation of internal olefins catalyzed by Rh complex with Tetrabi-type 磷 ligands. Liu, Guodu; Huang, Kexuan; Cao, Bonan; Chang, Mingxin; Li, Shengkun; Yu, Shichao; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Org. Lett. 2012, 14, 102.
11.Highly regioselective hydroaminomethylation of terminal olefins to linear amines using Rh complexes with a Tetrabi 磷 ligand. Liu, Guodu; Huang, Kexuan; Cai, Chaoxian; Cao, Bonan; Chang, Mingxin; Wu, Wenjun; Zhang, Xumu. Chem. Eur. J. 2011, 17, 14559.
12.Ruthenium-catalyzed asymmetric hydrogenation of β-keto enamines: an efficient approach to chiral γ-amino alcohols. Geng, Huiling; Zhang, Xiaowei; Chang, Mingxin; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 3039.
13.Highly regioselective isomerization-hydroformylation of internal olefins catalyzed by 銠/tetraphosphine complexes. Cai, Chaoxian; Yu, Shichao; Liu, Guodu; Zhang, Xiaowei; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 2665.
14.A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an Iridium catalyst. Chang, Mingxin; Li, Wei; Zhang, Xumu. Angew. Chem. Int. Edit. 2011, 50, 10679.
15.Spiro-2,2'-bichroman-based bisoxazoline (SPANbox) ligands for Zn(II)-catalyzed enantioselective hydroxylation of β-keto esters and 1,3-diester. Li, Jie; Chen, Gang; Wang, Zheng; Zhang, Ruzhou; Zhang, Xumu; Ding, Kuiling. Chem. Sci. 2011, 2, 1141.
16.New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation. Sun, Tian; Hou, Guohua; Ma, Miaofeng; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 253.
17.Enantioselective synthesis of optically pure β-amino ketones and γ -aryl amines by Rh-catalyzed asymmetric hydrogenation. Geng, Huiling; Huang, Kexuan; Sun, Tian; Li, Wei; Zhang, Xiaowei; Zhou, Le; Wu, Wenjun; Zhang, Xumu. J. Org. Chem. 2011, 76, 332.
18.Synthesis of enamides via Cu(I)-catalyzed reductive acylation of ketoximes with NaHSO3. Guan, Zheng-Hui; Zhang, Zhi-Yuan; Ren, Zhi-Hui; Wang, Yao-Yu; Zhang, Xumu. J. Org. Chem. 2011, 76, 339.
發明專利：
“New Chiral Ferrocene Phosphines and Their Applications for Asymmetric Catalytic Reactions” X. Zhang, US patent 09/781,083, filed February 9, 2001 and PCT/US01/044.
2."3,3'-Substituted Chiral Biaryl Phosphines and Phosphintes for Asymmetric Catalytic Reactions ” X. Zhang, U. S. Patent, filed November 16, 2001 and PCT Application.
3."New Transition Metal Catalyzed Reactions” A. Lei, X. Zhang, U. S. Provisional Patent, filed March 30, 2001.
4. “New Chiral Phospholanes for Asymmetric Catalysis” X. Zhang, US Patent filed November 6, 2001.
5. “P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US provisional Patent, November 10, 2001.
6. “Asymmetric Reductive Amination of Ketones” X. Zhang, US Provisional Patent, filed October 25, 2002.
7.“P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US Patent, November 10, 2002.
8. “New Chiral 惡唑啉 Ligands for Asymmetric Catalysis” D. Liu, X. Zhang, US Provisional Patent, December 17, 2003.
9.“Asymmetric Hydrogenation of Alpla-amino Carbonyl Compounds” X. Zhang, US Provisional Patent, January 10, 2004
10.“Preparation of chiral cyclic amino acids and derivatives” X. Zhang, W. Tang, US Patent 2004242889.
11.“P-Chiral Phospholanes and Phosphocyclic Compounds and their use in Asymmetric Catalytic Reactionss” X. Zhang, W. Tang, US patent 2004229846.
12. “Catalytic Asymmetric Reductive Amination of Ketones Via Transition Metal Complex Catalyst with Chiral 磷化氫 Ligands” X. Zhang, PCT, 2004, WO 2004058982.
13. “Preparation of Chiral 磷 Cyclic Compounds for Transition Metal-Catalyzed Asymmetric Reactions” X. Zhang, US patent, 2004, 2004072680.
14. “A preparation of aminoalcohols via asymmetric hydrogenation of beta-aminocarbonyl compounds” Zhang,
15.Xumu. US 2005159604 A1 20050721 Patent written in English. Application: US 2005-36157 20050114.
16.“New 惡唑啉 ligands for asymmetric catalysis” Zhang, Xumu; Liu, Duan. U.S. Pat. Appl. Publ. (2005), 2005137403 A1 20050623.
17. “Chelating Tetraphosphorus Ligands with 1,1’-聯苯 backbone for transition Metal-catalyzed hydroformylation of Alkenes and Related Reactions” X. Zhang; Y. Yan, PCT Int. Appl. (2007) 2007078859. A2 20070712.
18.新型三齒膦配體及其在線性氫甲酰化及類似反應中的應用（P）. 張緒穆，陳才友. 中國發明專利，CN102875599. 2013-01-16.
獲獎記錄
Franklin Veatch Graduate Fellowship, 1991, Stanford University
The camille and Henry Dreyfus Foundation New Faculty Award, 1994
都彭 Young Faculty Award, 1996
Office of Naval Research Young Investigator Award, 1996
The Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1998
The John Simon Guggenheim Foundation Fellow, 2000
The Outstanding Oversea Chinese Young Scientist B, Chinese Academy of Sciences, 2000
The Penn State Faculty Scholar Medal, 2001
The Young Innovation Award of ChiTec (Chinese High Tech) in 化學, 2001
The American Chemical Society Arthur C. Cope Scholar Award, 2002
The SDCA (San Diego Chinese Association) Achievement Award, 2002
Guest The Professor of Shanghai Institute of Organic Chemistry
Guest Professor of 大連市 Institute of Chemical Physics
Guest Professor of Wuhan University
2008年，蘇州工業園區第二屆科技領軍人才
2008年， “江蘇省高層次創新創業人才引進計劃”引進人才；
2009年，姑蘇創新創業領軍人才；
2011年, 獲2010年度“中國經濟十大創新人物”。
參考資料 >
師資隊伍——張緒穆.南方科技大學——師資隊伍.2015-11-16