尤明：現(xiàn)為威斯康星醫(yī)學(xué)院副院長(zhǎng)、II級(jí)教授和癌癥研究中心所長(zhǎng)。本科畢業(yè)于北京大學(xué)醫(yī)學(xué)部，在俄亥俄州洲大學(xué)醫(yī)學(xué)院獲病理學(xué)博士學(xué)位。尤明教授是美國(guó)國(guó)家癌癥研究所（NCI）癌癥易感性及化學(xué)預(yù)防智囊團(tuán)成員和化學(xué)預(yù)防藥物發(fā)展研究集團(tuán)審查小組主席，美國(guó)國(guó)家衛(wèi)生研究所（NIH）化療/飲食預(yù)防和化學(xué)病理學(xué)研究組成員。還擔(dān)任世界著名期刊Cancer Research和Cancer Prevention副主編，PLoS One學(xué)術(shù)主編，Carcinogenesis、Translational Oncogenomics和Application of Clinical Genetics等世界著名期刊編委。研究領(lǐng)域?yàn)?a href="/hebeideji/4808988875322545755.html">腫瘤學(xué)，研究方向?yàn)?a href="/hebeideji/7299607479166828563.html">肺癌的發(fā)病機(jī)制及其化學(xué)預(yù)防治療研究。主持評(píng)審NIH等科研課題40余項(xiàng)，在Cell 等世界頂尖雜志上發(fā)表SCI 論文280余篇，在肺癌的化學(xué)預(yù)防研究中取得了杰出成就。
基本介紹
研究方向
● 個(gè)體化用藥
● 肺癌的化學(xué)預(yù)防
● 嚙齒動(dòng)物和人類肺癌的易感基因研究
● 肺癌的分子發(fā)病機(jī)制
發(fā)表論文
pan J, Zhang Q, Li K, Liu Q, Wang Y, You M*. Chemoprevention of lungsquamous cell carcinoma by ginseng. Cancer Prev Res (Phila). 2013Jun;6(6):530-9.
Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F,Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, WangY, You M*. Exome sequencingidentifies MXRA5 as a novel cancer gene frequently mutated in non-small celllung carcinoma from Chinese patients. Carcinogenesis. 2012 Sep;33(9):1797-805.
Liu P, Morrison C, Wang L, Xiong D, Vedell P,Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, AndraeJW, Tschannen MR, jacob H,Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, PatelJ, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, StarnesS, Yang P, You M*. Identification ofsomatic mutations in non-small cell lung carcinomas using whole-exomesequencing. Carcinogenesis. 2012 Jul;33(7):1270-6.
Zhang Q, pan J, Wang Y, Lubet R, You M*. Beetroot 紅色 (betanin) inhibitsvinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis throughapoptosis. 摩爾 CarcinOrigen 2013 Sep;52(9):686-91.
Zhang Q, Pan J, North PE, Yang S, Lubet RA,Wang Y, You M*. Aerosolized3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicityCancer Prev Res (Phila). 2012 May;5(5):717-25.
Lu Y, Govindan R, Wang L, Liu PY, Goodgame B,Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M*. MicroRNA profiling andprediction of recurrence/relapse-free survival in stage I lung cancer.Carcinogenesis. 2012 May;33(5):1046-54.
Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M*. Genome-wide association andfine mapping of genetic loci predisposing to colon carcinogenesis in mice. MolCancer Res. 2012 Jan;10(1):66-74.
Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E,Hu M, Lubet RA, You M*.Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemicallyinduced oral carcinogenesis. 摩爾 CarcinOrigen 2013 Jan;52(1):49-56.
Lu Y, Liu P, Van den Bergh F, Zellmer V, JamesM, Wen W, Grubbs CJ, Lubet RA, You M*.Modulation of gene expression and cell-cycle signaling pathways by the EGFRinhibitor gefitinib (Iressa) in rat urinary bladder cancer. Cancer Prev Res(Phila). 2012 Feb;5(2):248-59.
Govindan R, Ding L, Griffith M, Subramanian J,Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J, Chen K, Walker J,McDonald S, Bose R, Ornitz D,Xiong D, You M, Dooling DJ, Watson M, Mardis ER, Wilson RK. Genomic landscape ofnon-small cell lung cancer in smokers and never-smokers. Cell. 2012 Sep14;150(6):1121-34.
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