來(lái)源：互聯(lián)網(wǎng)
LFA-1是指淋巴細(xì)胞功能相關(guān)分子。LFA-1局限在白細(xì)胞上表達(dá)，分布廣泛，可參與細(xì)胞毒T細(xì)胞(cytotoxic T lympholyte,CTL),自然殺傷細(xì)胞(natural kill cell,NK細(xì)胞)和淋巴細(xì)胞激活的殺傷細(xì)胞(lymphokine activated kill cell, LAK細(xì)胞)的殺傷效應(yīng)；輔助性T淋巴細(xì)胞對(duì)外來(lái)抗原和絲裂原的增生反應(yīng)；粒細(xì)胞及單核細(xì)胞介導(dǎo)的抗體依賴性細(xì)胞介導(dǎo)的細(xì)胞毒作用(antibody dependent cell-mediated cytotoxicity,ADCC);白細(xì)胞的定位、滲出和遷移、淋巴細(xì)胞向外周淋巴結(jié)的歸巢(homing)等，近來(lái)發(fā)現(xiàn)LFA-1在骨髓造血、干細(xì)胞歸巢和移植免疫中也具有重要作用。
參考資料 >