胡文輝博士，現任廣州醫科大學藥學院特聘教授，藥物化學專業博士生導師，兼學術委員會主任，廣東省分子靶標與臨床藥理重點實驗室副主任，呼吸病國家重點實驗室研究員。
在歷時20多年的新藥研究中，胡教授團隊已確立多個全新結構的候選藥物。其中，基于神經膠質細胞功能障礙的抗阿爾茲海默癥新藥AD16（GIBH130、達甲酮），已獲得國家食品藥品監督管理總局（CFDA）頒發的1.1類藥物臨床試驗批件（批件號：2016L02442，2016L02443，2016L02444），化合物專利涵蓋了全球多個國家。相關的研究以通訊作者的論文發表在Angewandte Chemie International Edition，Journal of Medicinal 化學、Organic Letters、European Journal of Medicinal Chemistry等學術刊物，并在Advanced Synthesis & Catalysis, ChemCatChem和科學通報上發表了封面文章。
人物經歷
胡文輝，男，博士生導師，廣東省“珠江學者”特聘教授，藥物化學學科帶頭人，廣州市蛇毒與生物毒素研究所所長，兼廣州醫科大學藥學院學術委員會主任，廣東省分子靶標與臨床藥理重點實驗室副主任，呼吸病國家重點實驗室研究員。
胡教授于2002年畢業于中國協和醫科大學藥物研究所，師從郭宗儒教授，開展抗炎藥物的研究，獲得博士學位。2002年-2006年在美國西北大學醫學院從事博士后研究，開展神經退行性疾病的藥物研究。2006年-2016年在中國科學院廣州生物醫藥與健康研究院歷任副研究員、研究員、新藥開發室主任。
2008年，胡文輝帶領團隊設計、發明了抗阿爾茲海默癥新藥AD16（哌噠甲片），2021年11月4日，哌噠甲酮片）已完成了一期臨床，呈現出良好的安全性和耐受性。
主要成就
立足于尚無有效藥物的重大疾病，胡文輝課題開展創新藥物的研究，建立了國內具有特色和優勢的新藥研發團隊。在歷時20多年的新藥研究中,胡教授團隊已確立多個全新結構的候選藥物。其中，基于神經膠質細胞功能障礙的抗阿爾茨海默氏癥新藥AD16（哌達甲酮），已獲得國家食品藥品監督管理總局（CFDA）頒發的1.1類藥物臨床試驗批件，正在開展臨床試驗中，化合物專利涵蓋了全球多個國家。截至目前，已發表了30多篇國際學術論文，申請了30多項國家、國際發明專利，兼任藥學學報的編委、廣東省藥學會藥物化學專業委員會副主委。
科研項目
已主持國家科技部、國家中華人民共和國國家自然科學基金委員會、廣東省科學技術廳的新藥重大專項，企業橫向經費等各類新藥基金近20項，金額逾2000多萬元。目前的在研課題：國家自然科學基金面上項目，81872743，神經膠質細胞調節劑AD110延緩阿爾茲海默癥的作用及機制研究。
學術論文
Ping Sun, Hu Yue, Qi Xing, Wenming Deng, Yitao Ou, Guangjin pan, Xiaofen Zhong*, Wenhui Hu*. Compound AD16 reduces amyloid plaque deposition and modifies microglia in a transgenic mouse model of Alzheimer's disease. ACS 藥理學 & Translational Science. 2020. (In Press).
Jianghong Dong, Mengjie Xiao, Qinge Ma, Guicheng Zhang, Weijie Zhao, Mengjie Kong, Yue Zhang, Luyun Qia, Wenhui Hu*. Design and synthesis of pinane oxime derivatives as novel anti-流行性感冒 agents. Bioorganic 化學 2020, 102, 104106-104106.
Nannan Wu, Guangyu Lian, Jingyi Sheng, Dan Wu, Huiyao Lan, Wenhui Hu*, Zhongjin Yang*. Discovery of a Novel Selective 液態水Soluble SMAD3 Inhibitor as an Antitumor Agent. Bioorganic Medicinal 化學 letter. 2020, 30 (17), 127396.
Yitao Ou, Ping Sun, NanNan Wu, Hao Chen, Wenhui Hu*, Zhongjin Yang*. Synthesis and biological evaluation of parthenolide derivatives as potential inhibitors of the NLRP3 inflammasome. Bioorganic Medinal 化學 letter. 2020, 30 (17), 127399.
Ping Sun, Wei Zhou, Hu Yue, Cheng Zhang, Yitao Ou, Zhongjin Yang*, Wenhui Hu*. Compound AD110 Acts as Therapeutic Management for Alzheimer’s Disease and Stroke in Mouse and Rat Models. ACS Chemical 神經科學, 2020, 11 (6), 929-938.
Wenmin Deng , Zhongjin Yang, Hu Yue, Yitao Ou, Wenhui Hu*, Ping Sun*. Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine, 2020, 152, 8-17.
Xin Zhao, Runfeng Li, Yang Zhou, Mengjie Xiao, Chunlong Ma, Zhongjin Yang, Shaogao Zeng, Qiuling Du, Chunguang Yang, Haiming Jiang, Yanmei Hu, Ping Sun, Jianghong Dong, Wei Cui, Kefeng Wang, Jun Wang, Yaoquan Tu, Zifeng Yang, Wenhui Hu*. Discovery of Highly Potent Pinanamine-Based Inhibitors Against Amantadine- and Oseltamivir-resistant 流行性感冒 A Viruses. Journal of Medicinal 化學 2018, 61, 5187?5198.
Zhengtu Li, Junling Zhao, Hongxia Zhou, Li Li, Yuyang Ding, Jing Li, Beixian Zhou,Haiming Jiang, Nanshan Zhonga, Wenhui Hu*, Zifeng Yang*. Cappariloside A shows antiviral and better anti-inflammatory effects against 流行性感冒 病毒 via regulating host IFN signaling, in vitro and vivo Life Sciences 200 (2018) 115–125.
Hui Xie, Shaogao Zeng, Yuwen He, Guicheng Zhang, Pengjiu Yu, Guifa Zhong, Hongjiang Xu, Ling Yang, Shanchun Wang, Xin Zhao*, Wenhui Hu*. Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. European Journal of Medicinal 化學, 2017, 141, 519-529.
Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu*, Zifeng Yang*. Pinanamine Is a Promising Lead Compound against 流行性感冒 A 病毒: Evidence from in Vitro and in vivo Efficacy Compared to Amantadine. Biol. Pharm. Bull. 2017, 40, 954–959.
Yunlong Zhao, Qingxin Zhao, LS Wang, Wen Hui Hu*, Jun Ling Zhao*. Organocatalytic Friedel-Crafts Alkylation /Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins. Angewandte Chemie International Edition. 2017, 56, 338 –342.
Wei Zhou, Guifa Zhong, Sihai Fu, Hui Xie, Tianyan Chi, Luyi Li, Xiurong Rao，Shaogao Zeng, Dengfeng Xu, Hao Wang, Guoqing Sheng, Xing Ji, Xiaorong Liu, Xuefei Ji, Donghai Wu, Libo Zou, Micky Tortorella, Kejian Zhang, and Wenhui Hu*. Microglia-based phenotypic screening identifies a novel inhibitor of neuroinflammation effective in Alzheimer's Disease Models. ACS Chemical 神經科學 2016, Nov 16; 7 (11):1499-1507.
Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu*. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus. European Journal of Medicinal 化學 2016, 108, 605-615.
Shengwei Chen, Qinxin Lou, Yuyang Ding, Shasha Zhang, Wenhui Hu* and Junling Zhao* Organocatalytic enantioselective Michael reaction of malononitrile to b,b-disubstituted nitroalkenes. Advanced Synthesis & Catalysis. 2015, 357, 2437-2441. (Front Cover and Very Important Publication).
Shengwei Chen, Guicheng Zhang, Qxinxin Lou, Wei Cui, Shasha Zhang, Wenhui Hu* and Junling Zhao*. Organocatalytic enantioselective aza-Michael reaction of benzotriazole to β,β-disubstituted nitroalkenes. ChemCatChem. 2015, 7, 1935-1938. (Inside Back Cover).
Yuyang Ding, Liufeng Mao, Dengfeng Xu, Hui Xie, Ling Yang, Hongjiang Xu, Wenjun Geng, Yong Gao, Chunguang Xia, Xiquan Zhang, Qingyi Meng, Donghai Wu, Junling Zhao * and Wenhui Hu*. C-aryl glucoside SGLT2 inhibitors containing a 聯苯 motif as potential anti-diabetic agents. Bioorganic Medinal Chemistry letter. 2015, 25, 2744-2748.
Bo Bi, Qin-Xin Lou, Yu-Yang Ding, Sheng-Wei Chen, Sha-Sha Zhang, Wen-Hui Hu* and Jun-Ling Zhao* Chiral phosphoric acid-catalyzed highly enantioselective Friedel-Crafts alkylation reaction of C3substituted indoles to unsaturated ketimino esters. Organic Letters, 2015, 17, 540?543.
Xin Zhao*, ZhenWei Zhang, Wei Cui, Shengwei Chen, Yang Zhou,Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu* and Wenhui Hu*. Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus. MedChemComm. 2015, 6, 727–731.
獲得榮譽
2011年獲得廣東省優秀共產黨員，2014年獲得廣東省優秀專利獎， 2018年獲“珠江學者”特聘教授，2020年獲廣東省科技進步一等獎（第二負責人）。
參考資料 >
胡文輝.廣州醫科大學藥學院.2021-12-26